Hydrogen Sulfide, Oxidative Stress and Periodontal Diseases: A Concise Review

Greabu, Maria; Totan, Alexandra; Miricescu, Daniela; Rădulescu, Radu; Virlan, Justina; Calenic, Bogdan

doi:10.3390/antiox5010003

Cited by 36 publications

(32 citation statements)

References 95 publications

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“…One of the primary metabolic by-products of D. oralis sulfate respiration, hydrogen sulfide, is well-known to trigger an inflammatory response at the leukocyteendothelium interface, acting as a primary signaling molecule and synergizing with the proinflammatory action of virulence factors (81,82). As we wanted to test the synthesis and potential proinflammatory action of potential virulence factors encoded by D. oralis, we grew the cells fermentatively, in the absence of sulfate.…”

mentioning

confidence: 99%

“…D. oralis encodes several sulfatases that could liberate inorganic sulfate from GAGs, potentially playing an active role in matrix destruction (93). In addition, the hydrogen sulfide produced by D. oralis during sulfate respiration can lead to apoptosis in keratinocytes (82,94) and further elicits a proinflammatory response in oral cells (95,96). These features illustrate the capacity of D. oralis to create a dysbiotic oral environment and actively contribute to the pathogenesis of periodontal disease in a novel and compounded way not described for other oral pathogens so far.…”

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confidence: 99%

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Insights into the Evolution of Host Association through the Isolation and Characterization of a Novel Human Periodontal Pathobiont,Desulfobulbus oralis

Cross

Chirania

Xiong

et al. 2018

mBio

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The human oral microbiota encompasses representatives of many bacterial lineages that have not yet been cultured. Here we describe the isolation and characterization of previously uncultured Desulfobulbus oralis, the first humanassociated representative of its genus. As mammalian-associated microbes rarely have free-living close relatives, D. oralis provides opportunities to study how bacteria adapt and evolve within a host. This sulfate-reducing deltaproteobacterium has adapted to the human oral subgingival niche by curtailing its physiological repertoire, losing some biosynthetic abilities and metabolic independence, and by dramatically reducing environmental sensing and signaling capabilities. The genes that enable free-living Desulfobulbus to synthesize the potent neurotoxin methylmercury were also lost by D. oralis, a notably positive outcome of host association. However, horizontal gene acquisitions from other members of the microbiota provided novel mechanisms of interaction with the human host, including toxins like leukotoxin and hemolysins. Proteomic and transcriptomic analysis revealed that most of those factors are actively expressed, including in the subgingival environment, and some are secreted. Similar to other known oral pathobionts, D. oralis can trigger a proinflammatory response in oral epithelial cells, suggesting a direct role in the development of periodontal disease.IMPORTANCE Animal-associated microbiota likely assembled as a result of numerous independent colonization events by free-living microbes followed by coevolution with their host and other microbes. Through specific adaptation to various body sites and physiological niches, microbes have a wide range of contributions, from beneficial to disease causing. Desulfobulbus oralis provides insights into genomic and physiological transformations associated with transition from an open environment to a host-dependent lifestyle and the emergence of pathogenicity. Through a multifaceted mechanism triggering a proinflammatory response, D. oralis is a novel periodontal pathobiont. Even though culture-independent approaches can provide insights into the potential role of the human microbiome "dark matter," cultivation and experimental characterization remain important to studying the roles of individual organisms in health and disease.KEYWORDS evolution, genome analysis, oral microbiology, periodontitis, proteomics

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mentioning

confidence: 99%

mentioning

confidence: 99%

Insights into the Evolution of Host Association through the Isolation and Characterization of a Novel Human Periodontal Pathobiont,Desulfobulbus oralis

Cross

Chirania

Xiong

et al. 2018

mBio

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“…Due to its toxicity to soil bacteria, CS 2 is less biodegradable in soil and is used as soil disinfectant. Excessive H 2 S is cytotoxic and lead to oxidative stress [55]. H 2 S is harmful to the metal-containing enzymes Table 2.…”

Section: Different Reasons May Explain the Observed Lower Toxicity Lementioning

confidence: 99%

Interactive Effect of Copper and Its Mineral Collectors on Soil Microbial Activity—A Microcalorimetric Analysis

Bararunyeretse¹,

Beckford²,

Ji³

2019

OJSS

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Discharge of metals and their mineral flotation collectors into the soil environment causes severe ecological and health impacts, which is still not fully understood. This is of great concern, particularly with regards to their effect on the soil microorganisms whose functions determine not only the soil quality and function but also influence the air and water quality. This study aimed to analyze and compare, microcalorimetrically, the single chemical toxic effect with the combined effect of copper (Cu) and two of its main flotation collectors, potassium amyl xanthate (PAX) and sodium isoamyl xanthate (SIAX), on soil microbial community. All chemicals, individually and as a binary mixture of copper and each of its flotation collectors, exhibited a significant dose-effect relationship, and the highest and lowest microbial activity inhibition being associated with SIAX and Cu, respectively (e.g. IC 50 of 447.5, 158.3 and 83.9 µg•g −1 soil for copper, PAX and SIAX, respectively). For all cases, the microbial activity was more affected by the mixture than by the individual mixture components. Increasing the xanthates dose (from 25 to 100 µg•g −1 soil) in the mixture with a copper dose of 200 µg•g −1 soil led to the increase of the microbial activity inhibition rate, from 23.08 % to 53.85% in case of PAX and from 26.92% to 57.69% in case of SIAX). Similarly, the toxicity level of the mixture of equitoxic components doses increased with the increased mixture doses. Since the observed activity level can be attributed to the surviving microbes, capable of adapting to both chemical and their mixture, a genetically based analysis should be conducted to allow identifying and characterizing the potentially resistant strains that can be useful for the remediation of the pollution by copper and xanthates and for the sustainability of copper mining and flotation, and for all soil, water, and air quality and function interest.

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“…H2S increased hydroxyl radical production in isolated mouse heart mitochondria and F2-isoprostanes in brains and hearts of mice [98]. H2S plays an important role in the proliferation and differentiation of human periodontal ligament stem cells (PDLSCs) [99, 100]. Human PDLSCs express both CBS and CSE and produce H2S.…”

Section: Stem Cell and H2s Signalingmentioning

confidence: 99%

Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration

Sen

2017

Journal of Molecular Biology

122

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Hydrogen sulfide (H2S) a novel gasotransmitter is endogenously synthesized by multiple enzymes that are differentially expressed in the peripheral tissues and central nervous systems. H2S regulates a wide range of physiological processes ranging from cardiovascular, neuronal, immune, respiratory, gastrointestinal, liver, and endocrine systems by influencing cellular signaling pathways and sulfhydration of target proteins. This review focuses on the recent progress made in H2S signaling that affects mechanistic and functional aspects of several biological processes such as autophagy, inflammation, proliferation and differentiation of stem cell, cell survival/death, and cellular metabolism under both physiological and pathological conditions. Moreover we highlighted the crosstalk between nitric oxide (NO) and H2S in several bilogical contexts.

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Hydrogen Sulfide, Oxidative Stress and Periodontal Diseases: A Concise Review

Cited by 36 publications

References 95 publications

Insights into the Evolution of Host Association through the Isolation and Characterization of a Novel Human Periodontal Pathobiont,Desulfobulbus oralis

Insights into the Evolution of Host Association through the Isolation and Characterization of a Novel Human Periodontal Pathobiont,Desulfobulbus oralis

Interactive Effect of Copper and Its Mineral Collectors on Soil Microbial Activity—A Microcalorimetric Analysis

Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration

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