Hydrogen sulfide inhibits skeletal muscle ageing by up‐regulating autophagy through promoting deubiquitination of adenosine 5’‐monophosphate (AMP)‐activated protein kinase α1 via ubiquitin specific peptidase 5
Jia‐He Yang,
Jun Gao,
Ya‐Qi E
et al.
Abstract:BackgroundHydrogen sulfide (H2S), the third gasotransmitter discovered, regulates a variety of physiological functions. Whether H2S alleviates skeletal muscle ageing by regulating autophagy has not been reported.MethodsMice were administered 150 mg/kg/day of
D‐galactose (
D‐gal), and C2C12 myotubes were cultured in 20 g/L
D‐gal to induce ageing. Sodium hydrosulfide (NaHS) was employed as an exogenous donor in the treatment group. The intracellular concentration of H2S was quantified by the 7‐azido‐4‐methylco… Show more
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