Hydrogen sulfide in the experimental models of arterial hypertension

Pharmacology of Hydrogen Sulfide and Its Donors in Cardiometabolic Diseases

“…Studies on hypertensive rats with NO synthase inhibition or SHR show a downregulation of vascular CSE expression and H 2 S production (Yan et al, 2004;Zhong et al, 2003). The H 2 S-generating enzyme expression and H 2 S contents are also observed in dahl salt-sensitive rats, Ang II-induced animals, and two-kidney-one-clip renovascular hypertension (Bełtowski and Kowalczyk-Bołtuć, 2023). Patients with arterial hypertension had lower circulating H 2 S levels and reduced expression of H 2 S-producing enzymes compared to healthy normotensive individuals (Greaney et al, 2017).…”

“…H 2 S donors reduce blood pressure in hypertenive models (Bełtowski and Kowalczyk-Bołtuć, 2023). These donors not only decrease blood pressure but also alleviate end-organ damage, including cardiovascular remodeling, kidney injury, and erectile dysfunction (Bełtowski and Kowalczyk-Bołtuć, 2023) interventions (Bełtowski and Kowalczyk-Bołtuć, 2023). Correlations between plasma H 2 S levels and systolic/diastolic blood pressure are observed (Whiteman et al, 2010a).…”

Hydrogen sulfide responsive nanoplatforms: Novel gas responsive drug delivery carriers for biomedical applications

“…As an endogenous signaling molecule, H 2 S has specific physiological functions that aid in the maintenance of cellular health in the circulatory system [18] , the nervous system, as well as many other organ systems [19] , [20] , [21] , [22] . These functions are attributed to the formation of protein persulfides through the conversion of cysteine residues [23] .…”

Diabetic Nephropathy and Gaseous Modulators

“…Recently, the role of garlic-derived polysulfide production and its prospective physiological relevance in cardiovascular protection through H 2 S and NO was elucidated [103]. It has been presumed that garlic-derived polysulfides, viz., diallyl sulfide, diallyl disulfide, and diallyl trisulfide, are the potent H 2 S donors, which facilitate increased bioavailability of NO through phosphorylation of eNOS, leading to cardiovascular protection [104]. However, a similar renoprotective role of garlic-derived polysulfides and simultaneous intervention of H 2 S in DN may be a subject of interest in future research.…”