Hydrogen Sulfide in Renal Physiology and Disease

Féliers, Denis; Lee, Hak‐Joo; Kasinath, Balakuntalam S.

doi:10.1089/ars.2015.6596

Cited by 92 publications

(81 citation statements)

References 108 publications

(112 reference statements)

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“…In addition, hydrogen sulphide regulates fundamental renal processes such as glomerular filtration and sodium reabsorption, both in the healthy organ and in different pathologies and ischemia [35]. …”

Section: Hydrogen Sulphide and Body Physiologymentioning

confidence: 99%

Sulphurous Mineral Waters: New Applications for Health

Carbajo

Maraver

2017

Evidence-Based Complementary and Alternative Medicine

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Sulphurous mineral waters have been traditionally used in medical hydrology as treatment for skin, respiratory, and musculoskeletal disorders. However, driven by recent intense research efforts, topical treatments are starting to show benefits for pulmonary hypertension, arterial hypertension, atherosclerosis, ischemia-reperfusion injury, heart failure, peptic ulcer, and acute and chronic inflammatory diseases. The beneficial effects of sulphurous mineral waters, sulphurous mud, or peloids made from sulphurous mineral water have been attributed to the presence of sulphur mainly in the form of hydrogen sulphide. This form is largely available in conditions of low pH when oxygen concentrations are also low. In the organism, small amounts of hydrogen sulphide are produced by some cells where they have numerous biological signalling functions. While high levels of hydrogen sulphide are extremely toxic, enzymes in the body are capable of detoxifying it by oxidation to harmless sulphate. Hence, low levels of hydrogen sulphide may be tolerated indefinitely. In this paper, we review the chemistry and actions of hydrogen sulphide in sulphurous mineral waters and its natural role in body physiology. This is followed by an update of available data on the impacts of exogenous hydrogen sulphide on the skin and internal cells and organs including new therapeutic possibilities of sulphurous mineral waters and their peloids.

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Section: Hydrogen Sulphide and Body Physiologymentioning

confidence: 99%

Sulphurous Mineral Waters: New Applications for Health

Carbajo

Maraver

2017

Evidence-Based Complementary and Alternative Medicine

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“…However, recent publications have revealed that H 2 S is synthesized in mammalian tissues, and freely travels through cell membranes. H 2 S acts independently of any specific transporters, and it has a number of biological effects on various systems (Meng et al, ; Cao and Bian, ; Feliers et al, ; Ianaro et al, ; Katsouda et al, ; Cheng et al, ). Nowadays, H 2 S is regarded as the third endogenous gasotransmitter followed by NO and CO (Hine et al, ).…”

Section: Introductionmentioning

confidence: 99%

Protein S‐sulfhydration by hydrogen sulfide in cardiovascular system

Meng

Zhao

Xie

et al. 2017

British J Pharmacology

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“…Hypertension and kidney disease both share common underlying pathways . Works that have been published demonstrate that NO, H 2 S, and the RAS act on the kidneys in synergy to regulate blood pressure (BP) and renal function . The spontaneously hypertensive rat (SHR) is a widely employed experimental model of hypertension.…”

Section: Introductionmentioning

confidence: 99%