Hydrogen sulfide in hemostasis: Friend or foe?

Hydrogen sulfide in signaling pathways

“…These enzymes are involved in the transsulfuration and reverse transsulfuration pathways as described earlier [10,18,[34][35][36][37]. CBS (the main H 2 S-producing enzyme in the central nervous system) and CSE (presents in the vasculature, liver and kidney) are the enzymes using amino acids: L-cysteine (which is synthesized from L-methionine through the transsulfuration), L-homocysteine and L-cystathionine to produce hydrogen sulfide with pyridoxal 5′ phosphate (vitamin B 6 ) as a cofactor [10,[37][38][39][40][41][42].…”

“…Results of Olson [23] showed that H 2 S concentrations are between 30 and 300 μM in plasma or blood. The level of H 2 S in various human tissues may depend on the donor's age and the method, which is used for measurement [18,24]. Endogenous level of H 2 S is modulated by different metabolic pathways, including H 2 S oxidation [25][26][27], which occurs in the mitochondria [9].…”

“…Hundreds of papers and books with the keywords: "hydrogen sulfide" and "H 2 S" have been published [1,10]. Numerous papers have demonstrated different roles of H 2 S in signaling pathways in a range of organisms, including both animals and plants [1,2,[11][12][13][14][15][16][17][18][19].…”

GYY4137, a Novel Water-Soluble, H2S-Releasing Molecule

“…In recent years much attention has been focussed on elucidating the functional roles of the gaseous mediator hydrogen sulfide (H 2 S) in biological systems (for reviews see, Guo, Cheng, & Zhu, 2013;Li, Rose, & Moore, 2011;Olas, 2014;Wang, 2012). It is now clear that biologically active quantities of H 2 S are synthesized naturally by a number of cell types in a range of different tissues in mammals, nonmammalian species, and even plants.…”

Estudo dos efeitos de compostos doadores de sulfeto de hidrogênio (H₂S) sobre o prurido agudo induzido pela ativação dos receptores ativados por proteases do tipo 2 (PAR-2) em camundongos.

“…Todas as enzimas estão expressas de forma ampla em vários tecidos, no entanto, a via da CBS contribui principalmente para a produção de H 2 S endógeno no sistema nervoso central. A CSE é uma das principais enzimas produtoras de H 2 S no sistema cardiovascular e o sistema 3MST/CAT no miocárdio (Olas, 2014). Recentemente foi encontrada em roedores uma nova via para a produção endógena de H 2 S, a qual usa como substrato o aminoácido D-cisteína envolvendo as enzimas D-amino-oxidase e 3MST (Shibuya et al, 2013 Uma vez produzido o H 2 S pode ser imediatamente liberado para exercer seus efeitos biológicos através da interação com diferentes moléculas sinalizadoras, ou pode ser armazenado no meio intracelular, como ligações de enxofre sulfano ou acido lábil enxofre, e liberado mais tarde em resposta a um sinal fisiológico (Ogasawara et al, 1994;Wang, 2012).…”