Hydrogen Sulfide (H2S) Releasing Capacity of Isothiocyanates from Moringa oleifera Lam.

Wang, Xiangshe; Liu, Yunjiao; Liu, Xingdi; Lin, Yi; Zheng, Xueqin; Lu, Yuyun

doi:10.3390/molecules23112809

Cited by 24 publications

(22 citation statements)

References 39 publications

(59 reference statements)

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“…This has laid sound ground for researchers to understand the basis for pharmacological and nutraceutical properties of ITCs [ 126 ]. ITCs release H₂S by forming adduct with cysteine, then the adduct undergoes intramolecular cyclization with the liberation of either H₂S and dihydrothiazole derivatives or organic amine and raphanusamic acid [ 127 , 128 , 129 ]. In the study by Testai et al [ 130 ] the H₂S-donor 4-carboxyphenyl isothiocyanate protected against ischemia/reperfusion (I/R)-mediated myocardial tissue injury [ 130 ].…”

Section: Mechanism Of Cardio- and Neuroprotective Effectmentioning

confidence: 99%

Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases

et al. 2022

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Neurodegenerative diseases (NDDs) and cardiovascular diseases (CVDs) are illnesses that affect the nervous system and heart, all of which are vital to the human body. To maintain health of the human body, vegetable diets serve as a preventive approach and particularly Brassica vegetables have been associated with lower risks of chronic diseases, especially NDDs and CVDs. Interestingly, glucosinolates (GLs) and isothiocyanates (ITCs) are phytochemicals that are mostly found in the Cruciferae family and they have been largely documented as antioxidants contributing to both cardio- and neuroprotective effects. The hydrolytic breakdown of GLs into ITCs such as sulforaphane (SFN), phenylethyl ITC (PEITC), moringin (MG), erucin (ER), and allyl ITC (AITC) has been recognized to exert significant effects with regards to cardio- and neuroprotection. From past in vivo and/or in vitro studies, those phytochemicals have displayed the ability to mitigate the adverse effects of reactive oxidation species (ROS), inflammation, and apoptosis, which are the primary causes of CVDs and NDDs. This review focuses on the protective effects of those GL-derived ITCs, featuring their beneficial effects and the mechanisms behind those effects in CVDs and NDDs.

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Section: Mechanism Of Cardio- and Neuroprotective Effectmentioning

confidence: 99%

Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases

et al. 2022

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“…Recently the role of H2S release from glucosinolates/isothiocyanates as a potent mechanism of protective action in the cardiovascular compartment and in the nervous system has been reported [22], as well as the role of H2S-mediated pain-relieving effects of natural and synthetic isothiocyanates [23]. Due to the presence of the polar O-glycosylated phenol substituent, moringin is a solid, odorless and relatively stable compound at room temperature; these are uncommon features for most isothiocyanates obtained by crucifer plants, such as benzyl-and allylisothiocyanate from mustard which are usually small and volatile compounds, with a pungent smell.…”

Section: Moringa Oleifera Lam a Multi-purpose Treementioning

confidence: 99%

Section: Moringa Oleifera Lam a Multi-purpose Treementioning

confidence: 99%

Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

Borgonovo

Petrocellis²,

Moriello³

et al. 2020

Molecules

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Moringa oleifera Lam. is a tropical plant widely used in traditional medicines and as a food supplement. It is characterized by the presence of glucosinolates and isothiocyanates; the stable isothiocyanate 4-[(α-l-rhamnosyloxy)benzyl]isothiocyanate (moringin) has been widely studied for its bioactivity as hypoglycemic, antimicrobial, anticancer and in particular for its involvement in nociception and neurogenic pain. Moringa extracts and pure moringin were submitted to in vitro assays with the somatosensory TRPA1 ion channel, proving that moringin is a potent and effective agonist of this receptor involved in nociceptive function and pain states. Moringin do not activate or activates very weakly the vanilloids somatosensory channels TRPV1,2,3 and 4, and the melastatin cooling receptor TRPM8. The comparison of moringin’s activity with other known agonists of natural origin is also discussed.

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“…In addition, H 2 S generated from 4-hydroxybenzyl ITC (HBITC), an ITC found in white mustard seeds (Sinapis alba), reportedly inhibits cellular proliferation of human neuroblastoma (SH-SY5Y) and glioblastoma (U87MG) cells (66). Wang et al showed H 2 S production in the tissue extracts of Moringa oleifera Lam; a species rich in GSLs and ITCs (179). Other studies indicate that subcutaneous and oral administrations of GRA or SFN reduced neuropathic pain in a dose-dependent manner in chemotherapy-induced neuropathy (91).…”

Section: Brassica Derived Sulfur Compoundsmentioning

confidence: 99%

Diet and Hydrogen Sulfide Production in Mammals

Rose

Moore

Whiteman

et al. 2021

Antioxidants & Redox Signaling

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In recent times it has emerged that some dietary sulfur compounds can act on mammalian cell signalling systems via their propensity to release hydrogen sulfide (H 2 S). H 2 S plays important biochemical and physiological roles in the heart, gastrointestinal tract, brain, kidney, and immune systems of mammals. Reduced levels of H 2 S in cells and tissues correlate with a spectrum of pathophysiological conditions including heart disease, diabetes, obesity and altered immune function. In view of the important roles for this molecule, researchers have now begun to explore the mechanisms by which dietary derived sulfur compounds, in addition to cysteine, can act as sources of H 2 S. Of the identified compounds, organic sulfides, isothiocyanates, and inorganic sulfur species including sulphate have received the most attention. Therefore, in the current review we will provide an overview of the literature focused on H 2 S release by these molecules. InnovationPathways for the production and catabolism of the gaseous signalling molecule H 2 S have now been characterised in mammalian systems. Dysregulation in these pathways is seen in numerous diseases spanning various cancers through to neurological disorders. Less widely reported are the impacts of diet including lipids, caloric restriction, vitamins, and minerals, on H 2 S producing systems in mammalian cells and tissues. Furthermore, recent research has shown that distinct pools of H 2 S may also be produced in cells following the metabolism of various dietary derived sulfur-containing phytochemicals. Therefore, a better understanding of how diet impacts on H 2 S, as described here, will enable a better understanding of gaseous signalling networks in mammalian cells and tissues.

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Hydrogen Sulfide (H2S) Releasing Capacity of Isothiocyanates from Moringa oleifera Lam.

Cited by 24 publications

References 39 publications

Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases

Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases

Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

Diet and Hydrogen Sulfide Production in Mammals

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