Hydrogen sulfide donors in research and drug development

Abstract

This review summarized most of the H2S donors such as inorganic compounds, natural products, anethole trithione derivatives and synthetic compounds used in research and drug development. These special bioactivities provided us some effective strategies for antiphlogosis, cancer therapy, cardiovascular protection and so on.

H2S Donors in creation of innovative drugs

“…Eфект пов'язують зі здатністю пригнічувати лейко-цитарну адгезію; збільшенням експресії ICAM-1 (молекул міжклітинної адгезії 1) [51]; пригнічен-ням транскрипції ряду прозапальних генів шля-хом регулювання активності NF-кВ. Проте також виявлені прозапальний ефект сірководню [52], що реалізується через підвищення концентрації TNF-α (фактор некрозу пухлин) у плазмі, та зни-ження активності мієлопероксидази [53].…”

GYY4137, a Novel Water-Soluble, H2S-Releasing Molecule

“…Clearly, using NaHS to probe for physiological roles of H 2 S is problematic. One approach to overcome this shortcoming has been the development of organic molecules which slowly release H 2 S at rates which are more akin to the rate expected from cells in vivo (Song et al, 2014).…”

“…Of particular interest are a number of structurally divergent molecule classes encompassing H 2 S releasing nonsteroidal antiinflammatory drugs (Isenberg et al, 2007;Sparatore et al, 2009), L-cysteine activated arylthioamide H 2 S donor molecules (Martelli et al, 2013), caged gem-dithiol derivatives that release H 2 S upon light stimulation (DevarieBaez et al, 2013) and molecules that release H 2 S in aqueous systems. Many of these compounds, that are now available commercially, have been reviewed elsewhere (Kashfi & Olson, 2013;Song et al, 2014). More recently, additional H 2 S donors have been introduced including poly(ethylene glycol)-ADT (PEG-ADT) (Hasegawa & van der Vlies, 2014), and S-aroylthiooximes (Foster, Powell, Radzinski, & Matson, 2014).…”

A Fast Hydrogen Sulfide–Releasing Donor Increases the Tumor Response to Radiotherapy

“…Moreover, H 2 S effects are also found in the nervous and endocrine systems, as well as in inflammation (5). Since the discovery that H 2 S is important for physiologic and pathologic processes, development and clinical applications of injectable donors allowing controlled and safe administration of the molecule have attracted growing interest (6). Because of their commercial availability, preclinical and clinical studies have been conducted using fast H 2 S-releasing inorganic salts, such as sodium hydrosulfide (NaHS) and sodium sulfide (Na 2 S; ref.…”