Hydrogen Sulfide Attenuates β2-Microglobulin-Induced Cognitive Dysfunction: Involving Recovery of Hippocampal Autophagic Flux

Chen, Si-Min; Yi, Yi-Li; Zhang, Dan; Tang, Yiyun; Kang, Xuan; Zhang, Ping; Zou, Wei; Tang, Xiao‐Qing

doi:10.3389/fnbeh.2019.00244

Cited by 11 publications

(6 citation statements)

References 60 publications

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“…TAA-induced ALF is a well-established rodent ALF model (28). The Y-maze and NOR tests are widely used as robust assays for assessing the cognitive function in mice (28).…”

Section: Discussionmentioning

confidence: 99%

“…TAA-induced ALF is a well-established rodent ALF model (28). The Y-maze and NOR tests are widely used as robust assays for assessing the cognitive function in mice (28). In the NOR test, NaHS administration led to marked increases in the discrimination index in the TAA-treated mice compared with mice treated with TAA alone, suggesting a protective effect of H 2 S on cognition.…”

Section: Discussionmentioning

confidence: 99%

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Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure

Yuan

Huang

et al. 2020

Exp Ther Med

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Acute liver failure (ALF) is a devastating clinical syndrome with a high mortality rate if not treated promptly. Previous studies have demonstrated the beneficial effects of hydrogen sulfide (H 2 S) on the brain and liver. The present study aimed to investigate the potential protective effects of H 2 S in ALF. A mouse model of ALF was established following treatment with thioacetamide (TAA). Mice with TAA-induced ALF were intraperitoneally injected with 30 or 100 µmol/kg/day sodium hydrosulfide (NaHS; a H 2 S donor drug) for two weeks. According to results from novel object recognition and Y-maze tests, in the present study, NaHS treatment alleviated cognitive deficiency and preserved spatial orientation learning ability in TAA-induced ALF mice compared with those of untreated mice. In addition, NaHS treatment reduced serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and the concentration of ammonia compared with those that received control treatment, resulting in weight loss prevention. These findings suggested a beneficial effect of H 2 S on liver function. In conclusion, results from the present study suggested that H 2 S treatment may alleviate cognitive deficiency and hepatic dysfunction in mice with ALF, indicating the potential therapeutic benefits of applying H 2 S for the treatment of ALF.

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“…TAA-induced ALF is a well-established rodent ALF model (28). The Y-maze and NOR tests are widely used as robust assays for assessing the cognitive function in mice (28).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure

Yuan

Huang

et al. 2020

Exp Ther Med

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“…Researchers from the University of South China, led by Tang Xiaoqing, discovered that H 2 S can reduce the effects of β2-microglobulin-induced cognitive dysfunction by restoring blocked autophagic flux in the hippocampus. This finding raises the possibility that H 2 S functions as a defense against β2-microglobulin-induced cognitive dysfunction ( Chen et al, 2019 ). Italian researchers also discovered that the development of Alzheimer’s disease is associated with an increase in serum β2-microglobulin, although additional clinical research is required to validate this finding ( Dominici et al, 2018 ).…”

Section: Discussionmentioning

confidence: 98%

Higher serum β2-microglobulin is a predictive biomarker for cognitive impairment in spinal cord injury

Cui

Wang

Hao

et al. 2023

PeerJ

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Objective Recent studies have suggested that high levels of β2-microglobulin are linked to cognitive deterioration; however, it is unclear how this connects to spinal cord injury (SCI). This study sought to determine whether there was any association between cognitive decline and serum β2-microglobulin levels in patients with SCI. Methods A total of 96 patients with SCI and 56 healthy volunteers were enrolled as study participants. At the time of enrollment, specific baseline data including age, gender, triglycerides (TG), low-density lipoprotein (LDL), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), smoking, and alcohol use were recorded. Each participant was assessed by a qualified physician using the Montreal cognitive assessment (MoCA) scale. Serum β2-microglobulin levels were measured using an enzyme-linked immunosorbent assay (ELISA) reagent for β2-microglobulin. Results A total of 152 participants were enrolled, with 56 in the control group and 96 in the SCI group. There were no significant baseline data differences between the two groups (p > 0.05). The control group had a MoCA score of 27.4 ± 1.1 and the SCI group had a score of 24.3 ± 1.5, with the difference being significant (p < 0.05). The serum ELISA results revealed that the levels of β2-microglobulin in the SCI group were considerably higher (p < 0.05) than those in the control group (2.08 ± 0.17 g/mL compared to 1.57 ± 0.11 g/mL). The serum β2-microglobulin level was used to categorize the patients with SCI into four groups. As serum β2-microglobulin levels increased, the MoCA score reduced (p < 0.05). After adjustment of baseline data, further regression analysis showed that serum β2-microglobulin level remained an independent risk factor for post-SCI cognitive impairment. Conclusions Patients with SCI had higher serum levels of β2-microglobulin, which may be a biomarker for cognitive decline following SCI.

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“…The rate of autophagic protein degradation is termed autophagic flux. The GFP/RFP (green/red) ratio and the autolysosomes/autophagosomes (red/yellow) ratio are comment measurements for autophagic flux (Chen et al, 2019). The numbers of green, red, and yellow puncta were counted per transfected cell and the autophagic flux was quantified by the above two indicators.…”

Section: Methodsmentioning

confidence: 99%

Argpyrimidine bonded to RAGE regulates autophagy and cell cycle to cause periodontal destruction

Dong

Gao

et al. 2022

Journal Cellular Physiology

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Argpyrimidine (APMD), a methylglyoxal-arginine-derived product, is one of the main products of diabetes mellitus. We aimed to systematically investigate the role of APMD in regulating autophagy activity, with a specific focus on the finding of APDM binding molecule, matching amino acid residues, autophagy flux and proteins, cell cycle arrest, cell skeleton and migration, PI3K/AKT/mTOR pathways, inflammatory signals, alveolar bone destruction, and inhibition verification. In this study, binding to 59/94/121 amino acid residues of advanced glycosylation end product receptor (RAGE), APMD suppressed PI3K/AKT/mTOR pathway to attenuate cell survival of periodontal ligament cells (PDLCs). Simultaneously, autophagy proteins ATG5, Beclin1, and LC3-II/I expression ratio were upregulated while P62/SQSTM was downregulated. Cell cycle arrested at G0/G1 with enhancing Cyclin D1/CDK4 and decreasing Cyclin A/CDK2 expression. Inhibition of autophagy abrogated APMDinduced cell cycle arrest. Furthermore, the inflammation regulation network of matrix metalloproteinase (MMP)-2, MMP-9, MAPKs and NF-κB pathways were activated by APMD. Rat periodontal models confirmed that APMD induced alveolar bone resorption, increased inflammatory infiltrates, and degraded collagen fibers through RAGE and PI3K. APMD-induced autophagy, G0/G1 arrest, proinflammatory signals activating and periodontal destruction were reversed by RAGE knockdown while aggravated by PI3K inhibitor. This study provides the first evidence that APMD bind to RAGE to regulate autophagy and cell cycle of PDLCs through the PI3K/AKT/mTOR pathway, thereby promoting periodontal destruction.

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Hydrogen Sulfide Attenuates β2-Microglobulin-Induced Cognitive Dysfunction: Involving Recovery of Hippocampal Autophagic Flux

Cited by 11 publications

References 60 publications

Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure

Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure

Higher serum β2-microglobulin is a predictive biomarker for cognitive impairment in spinal cord injury

Argpyrimidine bonded to RAGE regulates autophagy and cell cycle to cause periodontal destruction

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