Hydrogen sulfide as a cryogenic mediator of hypoxia-induced anapyrexia

Kwiatkoski, Marcelo; Soriano, Renato Nery; Francescato, Heloı́sa Della Coletta; Batalhão, Marcelo Eduardo; Coimbra, Terezila Machado; Cárnio, Evelin C.; Branco, Luiz G.S.

doi:10.1016/j.neuroscience.2011.11.030

Cited by 39 publications

(36 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study we aimed to analyze the reactivity of the heme moiety in human CBS toward NO ⅐ , with the purpose of shedding light on CBS regulation by NO ⅐ , given its relevance in human (patho)physiology (23,30,31). We report that NO ⅐ binds to ferrous CBS tightly with K d Յ0.23 M (Fig.…”

Section: Discussionmentioning

confidence: 99%

NO• Binds Human Cystathionine β-Synthase Quickly and Tightly

Vicente

Colaço

Mendes

et al. 2014

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background:The H 2 S-generating human enzyme cystathionine ␤-synthase (CBS) is inhibited by NO ⅐ and CO. Results: NO ⅐ binds to the ferrous heme in human CBS much more quickly than CO and much more tightly than currently thought. Conclusion:Results support the physiological role of NO ⅐ in CBS regulation. Significance: CBS may integrate the cross-talk among NO ⅐ , CO, and H 2 S, major modulators in human (patho)physiology.

show abstract

Section: Discussionmentioning

confidence: 99%

NO• Binds Human Cystathionine β-Synthase Quickly and Tightly

Vicente

Colaço

Mendes

et al. 2014

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…To minimize such difficulties, small samples of cerebral tissue can be pooled together to assess an important question, that is, is the gas endogenous production increased, decreased or maintained during a given experimental condition? [For further details see (186,320,323)]. …”

Section: Basic Techniques and Approaches Used To Investigate No Co mentioning

confidence: 99%

Gaseous Mediators in Temperature Regulation

Branco

Soriano

Steiner

2014

Comprehensive Physiology

View full text Add to dashboard Cite

Deep body temperature (Tb) is kept relatively constant despite a wide range of ambient temperature variation. Nevertheless, in particular situations it is beneficial to decrease or to increase Tb in a regulated manner. Under hypoxia for instance a regulated drop in Tb (anapyrexia) is key to reduce oxygen demand of tissues when oxygen availability is diminished, leading to an increased survival rate in a number of species when experiencing low levels of inspired oxygen. On the other hand, a regulated rise in Tb (fever) assists the healing process. These regulated changes in Tb are mediated by the brain, where afferent signals converge and the most important regions for the control of Tb are found. The brain (particularly some hypothalamic structures located in the preoptic area) modulates efferent activities that cause changes in heat production (modulating brown adipose tissue activity and perfusion, for instance) and heat loss (modulating tail skin vasculature blood flow, for instance). This review highlights key advances about the role of the gaseous neuromodulators nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) in thermoregulation, acting both on the brain and the periphery.

show abstract

“…H 2 S can also produce metabolic depression (akin to ''suspended animation'') in small mammals (9,10), and it has been implicated in torpor and hibernation (159,160), anapyrexia (81), and hypoxia-induced radiation resistance (194). H 2 S has also been shown to protect cells from both hypoxiaand hyperoxia-induced redox imbalance and apoptosis (13,83,85,92,101,189,190).…”

Section: General Metabolismmentioning

confidence: 99%

Hydrogen sulfide as an oxygen sensor

Olson

2013

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

Significance: Although oxygen (O 2 )-sensing cells and tissues have been known for decades, the identity of the O 2 -sensing mechanism has remained elusive. Evidence is accumulating that O 2 -dependent metabolism of hydrogen sulfide (H 2 S) is this enigmatic O 2 sensor. Recent Advances: The elucidation of biochemical pathways involved in H 2 S synthesis and metabolism have shown that reciprocal H 2 S/O 2 interactions have been inexorably linked throughout eukaryotic evolution; there are multiple foci by which O 2 controls H 2 S inactivation, and the effects of H 2 S on downstream signaling events are consistent with those activated by hypoxia. H 2 S-mediated O 2 sensing has been demonstrated in a variety of O 2 -sensing tissues in vertebrate cardiovascular and respiratory systems, including smooth muscle in systemic and respiratory blood vessels and airways, carotid body, adrenal medulla, and other peripheral as well as central chemoreceptors. Critical Issues: Information is now needed on the intracellular location and stoichometry of these signaling processes and how and which downstream effectors are activated by H 2 S and its metabolites. Future Directions: Development of specific inhibitors of H 2 S metabolism and effector activation as well as cellular organelle-targeted compounds that release H 2 S in a timeor environmentally controlled way will not only enhance our understanding of this signaling process but also provide direction for future therapeutic applications. Antioxid. Redox Signal. 22, 377-397.

show abstract

Hydrogen sulfide as a cryogenic mediator of hypoxia-induced anapyrexia

Cited by 39 publications

References 61 publications

NO• Binds Human Cystathionine β-Synthase Quickly and Tightly

NO• Binds Human Cystathionine β-Synthase Quickly and Tightly

Gaseous Mediators in Temperature Regulation

Hydrogen sulfide as an oxygen sensor

Contact Info

Product

Resources

About