Hydrogen Sulfide and the Immune System

Rose, Peter; Zhu, Yi‐Zhun; Moore, Philip K.

doi:10.1007/978-981-16-0991-6_5

Cited by 6 publications

(1 citation statement)

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“…VSMC function contributes to the formation, growth/development, and even rupture of atherosclerotic plaque [ 20 ]. In the arterial wall, endogenous H 2 S dominant derived from VSMCs [ 70 ]. Numerous evidence, direct and indirect, including in vivo and in vitro studies, demonstrated that the endogenous CSE/H 2 S system may mediate VSMC proliferation, cell death (apoptosis, autophagy, ferroptosis), phage-like differentiation, and calcification, to participate in the pathophysiological process of plaque stability ( Figure 1 ).…”

Section: Cystathionine γ Lyase/hydrogen Sulfide Role In Atherosclerot...mentioning

confidence: 99%

The Role of Hydrogen Sulfide in Plaque Stability

Lin

Geng

2022

Antioxidants

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Atherosclerosis is the greatest contributor to cardiovascular events and is involved in the majority of deaths worldwide. Plaque rapture or erosion precipitates life-threatening thrombi, resulting in the obstruction blood flow to the heart (acute coronary syndrome), brain (ischemic stroke) or low extremities (peripheral vascular diseases). Among these events, major causation dues to the plaque rupture. Although the initiation, procession, and precise time of controlling plaque rupture are unclear, foam cell formation and apoptosis, cell death, extracellular matrix components, protease expression and activity, local inflammation, intraplaque hemorrhage, and calcification contribute to the plaque instability. These alterations tightly associate with the function regulation of intraplaque various cell populations. Hydrogen sulfide (H2S) is gasotransmitter derived from methionine metabolism and exerts a protective role in the genesis of atherosclerosis. Recent progress also showed H2S mediated the plaque stability. In this review, we discuss the progress of endogenous H2S modulation on functions of vascular smooth muscle cells, monocytes/macrophages, and T cells, and the molecular mechanism in plaque stability.

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Section: Cystathionine γ Lyase/hydrogen Sulfide Role In Atherosclerot...mentioning

confidence: 99%