Hydrogen Sulfide and Inflammatory Joint Diseases

Burguera, Elena F.; Meijide-Faílde, Rosa; Blanco, Francisco J.

doi:10.2174/1389450117666160829112824

Cited by 39 publications

(24 citation statements)

References 72 publications

(100 reference statements)

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“…H 2 S attenuates or enhances the inflammatory processes in animal models depending of the type of inflammation and H 2 S-concentration. H 2 S has several different actions [ 37 ]: it modifies proteins by S-sulfhydration [ 38 ], acts on ezymes (e.g., cytochrome c oxidase, kinases), and has influence on ion channels (e.g., L-type Ca 2+ channels, chloride channels, transient receptor potential ankyrin 1 (TRPA1) ion channel, and K ATP channel) [ 35 , 36 , 39 – 42 ]. Since we know that the capsaicin-sensitive sensory nerves densely innervate the joints and the TRPA1 receptors, expressed on these nerve terminals, a key molecule of nociception and local inflammatory responses [ 43 ], these ion channels can be a possible link between the mineral water and pain perception.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models

Tékus

Borbély

Kiss

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Arthritic diseases are the most frequent causes of chronic pain and disability. Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and progressive structural joint damage. Osteoarthritis is a degenerative process of the articular cartilage associated with hypertrophic changes in the bone. The aim of the present study was to investigate the anti-inflammatory and analgesic effects of Hévíz thermal water and mud in monosodium iodoacetate- (MIA-) (25 mg/ml, 20 μl i.a.) induced osteoarthritis and Complete Freund's adjuvant- (CFA-) (1 mg/ml, 50–50 μl s.c) induced rheumatoid arthritis murine models. The mechanonociceptive threshold of female NMRI mice (n=6– 8 mice/ group) was measured by aesthesiometry, and paw volume was monitored with plethysmometry, knee joint diameter with digital micrometer, and dynamic weight bearing on the hind limbs with a Bioseb instrument. Periarticular bone destruction was assessed by SkyScan 1176 in vivo micro-CT. Inflammatory cytokines were detected by ELISA in plasma samples. Treatments (30 min, every working day) with tap water, sand, and a combined therapy of tap water and sand served as controls. Hévíz medicinal water and combined treatment with water and mud significantly decreased the mechanical hyperalgesia and knee oedema in MIA-induced osteoarthritis model. However, balneotherapy did not influence mechanical hyperalgesia, weight bearing, or oedema formation induced by CFA. Neither medicinal water nor mud treatment ameliorated deep structural damage of the bones or the joints in the animal models. On the basis of the present findings, we conclude that balneotherapy is an effective complementary treatment to reduce the pain sensation and swelling in degenerative joint diseases such as osteoarthritis. Our experimental data are in agreement with the previous human studies that also confirmed antinociceptive and anti-inflammatory effects of thermal water and Hévíz mud treatments.

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Section: Discussionmentioning

confidence: 99%

Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models

Tékus

Borbély

Kiss

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…For instance, different exposure time periods or concentrations may bring the opposite results . In truth, the earlier studies usually examine the inflammatory role of H 2 S with fast dissolving salts, such as NaHS, Na 2 S, or Lawesson’s reagent (LR), to produce and deliver H 2 S. These donors generate an immediate burst of H 2 S that lasts a few seconds . However, the release of endogenous H 2 S from cells is likely to occur in smaller quantities and much more slowly than that from sulfide salts, and thus these H 2 S donors maybe not good models for physiologic H 2 S generation.…”

Section: Discussionmentioning

confidence: 99%

“…*P < .05 that lasts a few seconds. 54 However, the release of endogenous H 2 S from cells is likely to occur in smaller quantities and much more slowly than that from sulfide salts, and thus these H 2 S donors maybe not good models for physiologic H 2 S generation. In the present study, we chose GYY4137, a slow-releasing H 2 S donor that newly synthesized by Moore's group, 55 to investigate the effect of H 2 S on wear debris-induced osteolysis in vivo and in vitro.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen sulfide protects against particle‐induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening

et al. 2020

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Wear debris‐induced osteolysis and ensuing aseptic loosening is the main cause of implant failure and revision surgery. Wear debris‐induced inflammatory response plays key roles in peri‐implant osteolysis. Recently, substantial of evidence suggests that hydrogen sulfide (H2S), the third gasotransmitter, is a critical player regulating inflammation. However, the role and therapeutic potential of H2S in wear debris‐induced inflammation and osteolysis remains to be defined. In the present study, we investigated the effect of H2S on wear debris‐induced pro‐inflammatory cytokines expression and osteolysis in vitro and in vivo. With a slow‐releasing H2S donor GYY4137, our study demonstrated that H2S attenuated wear debris‐induced osteolysis and osteoclastogenesis in murine calvaria resorption models. The expression of tumor necrosis factor‐alpha (TNF‐α), interleukin‐1β (IL‐1β), and interleukin‐6 (IL‐6) that stimulated by wear particles were significantly reduced by GYY4137. Further, the level of sirtuin 1 (SIRT1), which possesses anti‐inflammation property, was examined in vivo and in macrophages. And we found that wear debris decreased the expression of SIRT1. Cotreated macrophages with GYY4137 in part reversed the decline of SIRT1. More importantly, with the SIRT1 recombinant lentivirus and small interfering RNAs (siRNA) against SIRT1, our data indicated that SIRT1 mediated the inhibitory effects of GYY4137 on wear debris‐induced inflammation. Collectively, these results suggested that exogenous H2S production (via H2S donors) may represent a potential approach for the treatment of wear particle‐induced osteolysis.

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“…The earliest studies used fast-dissolving salts, such as NaSH. Positive results have also been obtained when H2S is administered as a sulfur water bath [38].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Crenotheraphy with SHS Water on the Concentration of Glutathione in Blood of People with Rheumatoid Arthritis

Błońska-Sikora¹,

Orlewska²,

Klusek³

2018

Preprint

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The tripeptide-glutathione (GSH, γ-L-glutamyl-L-cysteinyl-glycine) is one of the most important low molecular antioxidant in human body. Enhancing GSH and associated enzymes represents an aim in the search for cytoprotective strategies against cancer, neurologic degeneration, pulmonary and inflammatory conditions, as well as rheumatoid arthritis (RA).The objective of the study was to agree whether crenotherapy (drinking therapy) with sulfide/hydrogen sulfide (SHS) waters from “Zuzanna” spring located in the area of Busko-Zdrój in Poland leads to increasing of reduced glutathione (GSH) content in human blood. SHS water in distinct from mineral water is characterised by specific pharmacokinetic, invariable content and natural microbiological purity. SHS waters contain at least 1 g of total sulfur per kilogram of water and a treatment effect also depends on other bioelements. The method employing capillary electrophoresis with UV detector for the analysis of glutathione in human blood was developed. The group of 106 volunteers consisted of both women and men, in different age range. The therapy with SHS waters lasted 2 weeks. We recently demonstrated that the administration of hydrogen sulfide (H2S) in SHS waters increases GSH concentration in blood, and therefore crenotherapy could be used in therapeutics.

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Hydrogen Sulfide and Inflammatory Joint Diseases

Cited by 39 publications

References 72 publications

Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models

Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models

Hydrogen sulfide protects against particle‐induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening

The Influence of Crenotheraphy with SHS Water on the Concentration of Glutathione in Blood of People with Rheumatoid Arthritis

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