Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis

Wang, Ying; Sha, Lei; Pan, Zihan; Jiang, Simin; Fan, Jia; Yu, Siwang; Xue, Lixiang; Yang, Jun; Ma, Shaohua; Liu, Tong; Zhang, Jing; Chen, Yahong

doi:10.1016/j.freeradbiomed.2022.04.014

Cited by 88 publications

(45 citation statements)

References 35 publications

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“…Increasing FPN1 expression and inhibiting the degradation of FTH reduce intracellular iron accumulation (Gao et al, 2016;Hou et al, 2016). H 2 S inhibits ferritinophagy signaling by activating NRF2 and PPAR-γ, which suppress ferroptosis (Wang et al, 2021;Wang et al, 2022). In our study, the NRF2 protein expression also changed when the expressions of FTH and FPN1 were enhanced after exogenous H 2 S supplementation.…”

Section: Discussionsupporting

confidence: 55%

“…However, our study also demonstrated the effects of H 2 S on the expressions of FTH and FPN1 in cardiomyocytes. FPN1 is the only known mammalian iron export protein, and FTH is the main iron storage protein in cells (Tian et al, 2021;Wang et al, 2022). Increasing FPN1 expression and inhibiting the degradation of FTH reduce intracellular iron accumulation (Gao et al, 2016;Hou et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

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Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats

Liang

Miao

Teng

et al. 2022

Front. Mol. Biosci.

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Aging contributes significantly to cardiovascular diseases and cardiac dysfunction. To explore the reasons for the decline in cardiac function in the elderly, we collected clinical data and blood samples from 231 individuals. Our results indicated that aging was accompanied by a decline in cardiac function and remodeling of the left ventricle, and cardiac function was negatively correlated with age. Serum hydrogen sulfide (H2S) decreased, while serum malondialdehyde (MDA) and iron increased with aging in healthy individuals. A rat model of aging and iron overload was constructed for in vivo research. In the animal model, we found that the expression of endogenous H2S-producing enzymes decreased, and endogenous H2S levels decreased, while oxidative stress levels rose. The regulation of iron metabolism and the maintenance of iron homeostasis declined. The accumulation of MDA and iron led to ferroptotic cell death and subsequent myocardial injury and deterioration. A high-iron diet accelerated the aging process and death in rats. The decline of cardiac function in aging rats and iron-overload rats may be caused by cardiomyocyte ferroptosis. Exogenous H2S enhanced the expression of endogenous H2S synthase, promoted endogenous H2S production, regulated iron metabolism, and reduced oxidative stress levels. The protective effects of H2S on cardiac function in aging rats and iron-overload rats may be partly due to the inhibition of cardiomyocyte ferroptosis. We demonstrated that cardiac dysfunction associated with aging was closely related to decreased endogenous H2S levels and cardiomyocyte ferroptosis. H2S-regulated iron metabolism reduced oxidative stress levels in cardiomyocytes, inhibited cardiomyocyte ferroptosis, and protected cardiac function in aging rats.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats

Liang

Miao

Teng

et al. 2022

Front. Mol. Biosci.

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“…How does the SIRT1-SIRT3 axis modulate ferroptosis? Previous evidence has shown that changes in the mitophagy balance can affect the incidence of ferroptosis [43]. SIRT1 and SIRT3 are closely related to mitophagy.…”

Section: Discussionmentioning

confidence: 91%

Abnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1/Parkin signalling pathway

Liao

Long

et al. 2023

Preprint

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Myocardial ischemia-reperfusion injury (MIRI) is the main reason for the poor prognosis of patients with ischemic cardiomyopathy (ICM). To date, the mechanism of MIRI remains unknown. As members of the silent information regulator 2 (SIR2) family, SIRT1 and SIRT3 have been shown to play critical roles in protecting cardiomyocytes against MIRI, but whether SIRT1 and SIRT3 interact to regulate mitophagy and their association with ferroptosis during MIRI have not been reported. Hence, in this study, we investigated the role and specific mechanism of SIRT1 and SIRT3 in protecting cardiomyocytes against MIRI through bioinformatics analysis and cell experiment methods. Meanwhile, we also elucidated the interaction between SIRT1 and SIRT3 during MIRI. We found that the expression of SIRT1 and SIRT3 in myocardial tissues and the peripheral blood of patients with ICM was abnormal, and SIRT1 was significantly negatively correlated with SIRT3 during MIRI. Further analysis revealed that the SIRT1-SIRT3 axis was closely correlated with ferroptosis, and its silencing could effectively increase the incidence of ferroptosis. Furthermore, SIRT1-SIRT3 axis silencing was accompanied by changes in PINK1, Parkin, P62/SQSTM1 and LC3 expression. PINK1 silencing significantly increased the incidence of ferroptosis, while resveratrol (Res) and/or honokiol (HKL) effectively reversed the outcome. These results suggests that abnormalities in the SIRT1-SIRT3 axis promote MIRI through ferroptosis caused by silencing the PINK1/Parkin signalling pathway, which may provide promising therapeutic prospects for patients with ICM.

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“…COPD is a common and preventable respiratory disease characterized by persistent airfow limitation. Except β2 agonist and glucocorticoid, growing novel strategies, such as Nrf2 agonist, prebiotics, stem cell transplantation, and oligonucleotides have been considered [34][35][36][37][38][39][40], but there is no efcient treatment to prevent its progression. Patients are treated with drugs to keep the airway unobstructed and improve the symptoms of dyspnea, chest tightness, and wheezing [13].…”

Section: Discussionmentioning

confidence: 99%

Effects of Ipratropium Bromide Combined with Traditional Chinese Medicine Intervention on the Pulmonary Function and Psychological Status of Patients with Chronic Obstructive Pulmonary Disease

Zhao

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Recently, most scholars have advocated multidisciplinary comprehensive intervention measures for chronic obstructive pulmonary disease (COPD) to improve lung function, relieve symptoms of dyspnea, and improve quality of life. Traditional Chinese medicine (TCM) has rich experience in the treatment of various respiratory system diseases and the rehabilitation of their syndrome differentiation. In this study, total 68 patients with COPD from November 2019 to November 2021 in the hospitals were divided into the control group, ipratropium bromide (IB)-treated group, and IB + TCM-treated group for clinical efficacy observation and to explore the effect of IB combined with TCM on the pulmonary function and psychological status of COPD patients. Patients in the control group were subjected to routine oxygen inhalation, cough and expectorant, and antiviral treatments, while the patients in the IB-treated group were treated with IB and those received in the control group. Patients in the IB + TCM-treated group were treated with IB and TCM intervention. All patients were treated for a month. The results showed that after different interventions, the levels of FEV1, FEV1% pred, FVC, and PEF ( P < 0.05) were significantly increased in all the groups, while levels of TNF-α, IL-6, IL-8, and CRP in serum as well as Hamilton Anxiety Scale and Hamilton Depression scores were significantly decreased. Compared with the control group and IB-treated group, the IB + TCM-treated group presented the greatest changes on all abovementioned indicators and the lowest total incidence of adverse reactions, indicating the biggest improvement of IB + TCM on the symptoms of COPD patients. Therefore, the combination of IB and TCM intervention effectively improved the pulmonary function and psychological status of COPD patients and could be used as an important adjunct for COPD treatment.

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Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis

Cited by 88 publications

References 35 publications

Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats

Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats

Abnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1/Parkin signalling pathway

Effects of Ipratropium Bromide Combined with Traditional Chinese Medicine Intervention on the Pulmonary Function and Psychological Status of Patients with Chronic Obstructive Pulmonary Disease

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