Hydrogen sulfide, a signaling molecule in plant stress responses

Zhang, Jing; Zhou, Mingguo; Zhou, Heng; Zhao, Didi; Gotor, Cecilia; Romero, Luís C.; Shen, Jie; Ge, Zhenglin; Zhang, Zhirong; Shen, Wenbiao; Yuan, Xuesong; Xie, Yanjie

doi:10.1111/jipb.13022

Cited by 133 publications

(121 citation statements)

References 118 publications

(359 reference statements)

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“…In plants, H 2 S has been shown to be essential in regulating a wide range of vital processes. H 2 S improves the tolerance and protection of plants to numerous adverse environmental conditions, and, in this way, it allows plant adaptability and viability, and its beneficial effects play a role in important aspects of development ( Zhang et al , 2021b ; Zhou et al , 2021b ). Sulfide also regulates critical processes, including autophagy and abscisic acid (ABA)-dependent stomatal movement ( Gotor et al , 2019 ; Laureano-Marín et al ., 2020 ; Zhang et al , 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Hydrogen sulfide signaling in plant adaptations to adverse conditions: molecular mechanisms

Aroca

Zhang

Xie

et al. 2021

Journal of Experimental Botany

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Hydrogen sulfide (H2S) is a signaling molecule that regulates critical processes and allows plants to adapt to adverse conditions. The molecular mechanism underlying the H2S action relies on its chemical reactivity, and the mainly characterized is the persulfidation, which involves the modification of protein thiol groups, resulting in the formation of persulfide groups. This modification derives a change of protein function, altering catalytic activity or intracellular location and inducing important physiological effects. H2S cannot react directly with thiols but instead can react with oxidized cysteine residues; therefore, H2O2 signaling through sulfenylation is required for persulfidation. A comparative study performed in this review reveals 82% of identity between the sulfenylome and persulfidome. With regard to abscisic acid (ABA) signaling, widespread evidence shows an interconnection between H2S and ABA in the plant response to environmental stress. Proteomic analyses have revealed persulfidation of several proteins involved in the ABA signaling network and have shown that persulfidation is triggered in response to ABA. In guard cells, a complex interaction of H2S and ABA signaling has also been described, and the persulfidation of specific signaling components seems to be the underlying mechanism.

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Section: Introductionmentioning

confidence: 99%

Hydrogen sulfide signaling in plant adaptations to adverse conditions: molecular mechanisms

Aroca

Zhang

Xie

et al. 2021

Journal of Experimental Botany

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“…Existing relationships and cross-talks between SSC have been excellently reviewed in several important papers [ 64 , 65 , 66 , 67 , 68 , 69 ], and interested readers can find comprehensive information. However, a detailed survey on the interactions of the four compounds taking place during heavy metal exposure is still missing.…”

Section: Major Players In Chemical Priming Towards Toxic Metal(loid) Tolerancementioning

confidence: 99%

“…As these new drug formulations are developed, some of them may be applied in plant systems as prospective priming compounds (see the subsections below). The most important for broad agricultural exploitation is the low cost of a donor compound and the ease of simultaneous treatment of numerous seeds/plants [ 69 ].…”

Section: Major Players In Chemical Priming Towards Toxic Metal(loid) Tolerancementioning

confidence: 99%

Priming Strategies for Benefiting Plant Performance under Toxic Trace Metal Exposure

Wiszniewska

2021

Plants

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Combating environmental stress related to the presence of toxic elements is one of the most important challenges in plant production. The majority of plant species suffer from developmental abnormalities caused by an exposure to toxic concentrations of metals and metalloids, mainly Al, As, Cd, Cu, Hg, Ni, Pb, and Zn. However, defense mechanisms are activated with diverse intensity and efficiency. Enhancement of defense potential can be achieved though exogenously applied treatments, resulting in a higher capability of surviving and developing under stress and become, at least temporarily, tolerant to stress factors. In this review, I present several already recognized as well as novel methods of the priming process called priming, resulting in the so-called “primed state” of the plant organism. Primed plants have a higher capability of surviving and developing under stress, and become, at least temporarily, tolerant to stress factors. In this review, several already recognized as well as novel methods of priming plants towards tolerance to metallic stress are discussed, with attention paid to similarities in priming mechanisms activated by the most versatile priming agents. This knowledge could contribute to the development of priming mixtures to counteract negative effects of multi-metallic and multi-abiotic stresses. Presentation of mechanisms is complemented with information on the genes regulated by priming towards metallic stress tolerance. Novel compounds and techniques that can be exploited in priming experiments are also summarized.

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“…H 2 S functions in many physiological and pathological diseases in humans, such as Parkinson's, Huntington's and Alzheimer's neurodegenerative diseases [7]. In plant systems, the number of known physiological processes involving signaling and regulation by H 2 S has grown rapidly in the last few years, which include responses to stress processes such as metal, drought, salinity, hypoxia or developmental processes such as seed germination and root development [4,8,9]. Persulfidation of cysteine residues has been described as one of the molecular mechanisms by which H 2 S exerts its signaling function [10,11].…”

Section: Introductionmentioning

confidence: 99%

Label-Free Quantitative Proteomic Analysis of Nitrogen Starvation in Arabidopsis Root Reveals New Aspects of H2S Signaling by Protein Persulfidation

2021

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Hydrogen sulfide (H2S)-mediated signaling pathways regulate many physiological and pathophysiological processes in mammalian and plant systems. The molecular mechanism by which hydrogen sulfide exerts its action involves the posttranslational modification of cysteine residues to form a persulfidated thiol motif. We developed a comparative and label-free quantitative proteomic analysis approach for the detection of endogenous persulfidated proteins in N-starved Arabidopsis thaliana roots by using the tag-switch method. In this work, we identified 5214 unique proteins from root tissue that were persulfidated, 1674 of which were quantitatively analyzed and found to show altered persulfidation levels in vivo under N deprivation. These proteins represented almost 13% of the entire annotated proteome in Arabidopsis. Bioinformatic analysis revealed that persulfidated proteins were involved in a wide range of biological functions, regulating important processes such as primary metabolism, plant responses to stresses, growth and development, RNA translation and protein degradation. Quantitative mass spectrometry analysis allowed us to obtain a comprehensive view of hydrogen sulfide signaling via changes in the persulfidation levels of key protein targets involved in ubiquitin-dependent protein degradation and autophagy, among others.

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Hydrogen sulfide, a signaling molecule in plant stress responses

Cited by 133 publications

References 118 publications

Hydrogen sulfide signaling in plant adaptations to adverse conditions: molecular mechanisms

Hydrogen sulfide signaling in plant adaptations to adverse conditions: molecular mechanisms

Priming Strategies for Benefiting Plant Performance under Toxic Trace Metal Exposure

Label-Free Quantitative Proteomic Analysis of Nitrogen Starvation in Arabidopsis Root Reveals New Aspects of H2S Signaling by Protein Persulfidation

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