Hydrogen Sulfide, a Potential Cardioprotective Gas Activating a Life Span Regulator

Ueda, Kazutaka; Fukuma, Nobuaki; Takimoto, Eiki

doi:10.1536/ihj.16-252

Cited by 2 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Besides its well-known toxicity, H 2 S is now considered an endogenous gaseous signaling molecule in addition to nitric oxide and carbon monoxide and can be endogenously generated in mammalian tissues. Many studies have confirmed that H 2 S is a potential regulator of cardiovascular function and exerts a protective effect on the pathogenesis and progression of cardiovascular diseases, including hypertension, myocardial infarction, cardiac hypertrophy, and ischemic/reperfusion injury (Wang, 2012 ; Shen et al, 2015 ; Ueda et al, 2016 ). In addition, numerous studies have demonstrated that hydrogen sulfide is a vasodilator, that it decreases blood pressure acutely, that it acts as an anti-angiogenic and anti-inflammatory agent, and that cystathionine gamma lyase, a crucial endogenous enzyme contributed to production of H 2 S, knock-out mice are hypertensive (Yang et al, 2008 ; Yang and Wang, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Sulfide Facilitates the Impaired Sensitivity of Carotid Sinus Baroreflex in Rats with Vascular Calcification

Teng

Guo

et al. 2017

Front. Pharmacol.

View full text Add to dashboard Cite

Arterial baroreflex is a general mechanism maintaining cardiovascular homeostasis; its sensitivity is reduced in vascular calcification (VC). Hydrogen sulfide (H2S) treatment facilitates baroreflexive sensitivity in normal and hypertensive rats. Here, we aimed to detect the effect of H2S on baroreflexive sensitivity in rats with VC. The rat VC model was induced by vitamin D3 plus nicotine for 4 weeks. The sensitivity of baroreflex was detected by perfusing the isolated carotid sinus. VC was assessed by hematoxylin and eosin (H&E) staining, Ca2+ content and alkaline phosphatase (ALP) activity. Protein levels were detected by western blot analysis. Vitamin D3 plus nicotine induced structural disorder and elevated Ca2+ content in the aortic and carotid arterial wall and increased plasma ALP activity. In the calcified aorta and carotid artery, protein levels of contractile phenotype markers of vascular smooth muscle cells (VSMCs) were downregulated and that of osteoblast-like phenotype markers and endoplasmic reticulum stress (ERS) markers were upregulated. NaHS treatment ameliorated the histologic disorder and Ca2+ content in the calcified aorta and carotid artery, inhibited the elevated plasma ALP activity, and prevented the transformation of the VSMC phenotype and activation of ERS in rats with VC. Chronic NaHS treatment prevented the impairment of the baroreflex sensitivity and acute NaHS treatment dose-dependently improved the sensitivity in rats with VC. Our results suggested that H2S could directly facilitate the impairment of baroreflex in rats with VC and ameliorate VC, which might provide new target and strategy for regulation of the baroreflex and therapy of VC.

show abstract

Section: Introductionmentioning

confidence: 99%

Hydrogen Sulfide Facilitates the Impaired Sensitivity of Carotid Sinus Baroreflex in Rats with Vascular Calcification

Teng

Guo

et al. 2017

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…вазодилататора и антиагреганта способствовало росту исследований эффекта данного газотрансмиттера при сердечно-сосудистой патологии [38]. Выявлено, что как экзогенные доноры сероводорода, так и стимуляция его эндогенной продукции приводят к уменьшению зоны инфаркта, степени окислительного стресса, повреждения митохондрий, апоптоза и аутофагии в сердце при ишемии-реперфузии у экспериментальных животных [39].…”

Section: рисунок 1 -возможные механизмы защитного действия No при ишunclassified

The Role of Gasotransmitters (No and H2s) in Defence Mechanisms Against Postischemic Liver Injuries

Khodosovsky¹

2019

Hepatol Gastroenterol

View full text Add to dashboard Cite

УО «Гродненский государственный медицинский университет», Гродно, БеларусьПостишемические нарушения печени встречаются в клинической практике при выполнении трансплантации, резекции или травмах органа, когда возникает необходимость окклюзии афферентных сосудов. Цель обзора -анализ литературных и собственных данных о роли газотрансмиттеров NO и H 2 S в механизмах современных способов защиты печени при синдроме ее ишемии-реперфузии.Ключевые слова: печень, ишемия-реперфузия, газотрансмиттеры, кислородтранспортная функция, прооксидантно-антиоксидантный баланс Для цитирования: Ходосовский, М. Н. Роль газотрансмиттеров (NO и H 2 S) в механизмах защиты от постишемических нарушений печени / М. Н.

show abstract

Hydrogen Sulfide, a Potential Cardioprotective Gas Activating a Life Span Regulator

Cited by 2 publications

References 13 publications

Hydrogen Sulfide Facilitates the Impaired Sensitivity of Carotid Sinus Baroreflex in Rats with Vascular Calcification

Hydrogen Sulfide Facilitates the Impaired Sensitivity of Carotid Sinus Baroreflex in Rats with Vascular Calcification

The Role of Gasotransmitters (No and H2s) in Defence Mechanisms Against Postischemic Liver Injuries

Contact Info

Product

Resources

About