Hydrogen-rich water partially alleviate inflammation, oxidative stress and intestinal flora dysbiosis in DSS-induced chronic ulcerative colitis mice

Liu, Song; Zhang, Yao; Zhu, Chuang; XianBin, Ding; Yang, Li; Yan, Hongli

doi:10.1016/j.advms.2021.10.002

Cited by 17 publications

(13 citation statements)

References 38 publications

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“…Inflammation and oxidative stress are among the complications of UC disease playing major roles in disease pathogenesis. [27][28][29][30] Due to the increased secretion of reactive oxygen metabolites and pro-inflammatory cytokines from macrophages, the…”

Section: Discussionmentioning

confidence: 99%

Quinic acid ameliorates ulcerative colitis in rats, through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways

Ghasemi‐Dehnoo

Lorigooini

Amini‐Khoei

et al. 2023

Immunity Inflam & Disease

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ObjectiveIn this study, the therapeutic effect of quinic acid (QA), which has anti‐inflammatory activity, was investigated on acetic acid‐induced colitis in male Wistar rats.MethodsUlcerative colitis (UC) was induced in rats by acetic acid intrarectally, and the protective effects of QA in 10, 30, 60, and 100 mg/kg doses were investigated. Rats were treated for 5 days and their colon tissues were dissected out at the end. Macroscopic and histopathological examinations were performed in colon tissues. Also, the expression of inflammatory and apoptotic genes, including TLR4, IL‐1β, INOS, IL‐6, TNF‐α, NF‐κB, Caspase‐3, Caspase‐8, Bax, and Bcl‐2, was measured. Biochemistry indices, such as malondialdehyde (MDA) and nitrite oxide (NO) content, in addition to, total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and enzymes activities were also assessed.ResultsColitis increased the levels of MDA and NO, and enhanced the inflammatory and apoptotic gene expressions, while reducing the SOD and CAT enzymes activity, and TAC levels in the colitis rats. Also, results showed that colitis was associated with the infiltration of inflammatory cells, epithelium damage, and edema in colon tissue. QA significantly ameliorated histopathological indices, oxidative stress, inflammation, and apoptosis in colitis rats.ConclusionQA ameliorated UC through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways, which results in the reduction of colitis complications, including oxidative stress, inflammation, apoptosis and histopathological injuries in rats. Therefore it can be concluded, that QA exerts its therapeutic effects through antiapoptotic, antioxidant, and anti‐inflammatory properties.

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Section: Discussionmentioning

confidence: 99%

Quinic acid ameliorates ulcerative colitis in rats, through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways

Ghasemi‐Dehnoo

Lorigooini

Amini‐Khoei

et al. 2023

Immunity Inflam & Disease

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“…Moreover, it reduced the levels of ROS and MDA in the liver, indicating an improvement in the antioxidant properties of broilers and a reduction in the likelihood of oxidative stress. Previous studies have reported the antioxidant effects of hydrogen-rich water, such as alleviating chronic graft-versus-host disease in mice [18], and reducing oxidative stress in mice with DSS-induced chronic ulcerative colitis [19]. Shin et al[12] demonstrated that hydrogen-rich water increased T-AOC in broilers and elevated T-SOD activity in serum and breast tissue.…”

Section: Discussionmentioning

confidence: 99%

Effects of hydrogen-rich water on antioxidant capacity, meat quality and cecum mic robiota of broiler chickens

Zhu

Yang

Yao

et al. 2023

Preprint

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Background: Hydrogen-rich water, which contains a high concentration of dissolved hydrogen gas, exhibits numerous advantageous properties, including anti-inflammatory, antioxidant, and metabolic regulatory functions. Its exceptional biosafety renders it highly promising for implementation in agricultural production, particularly in light of the growing concern for food safety. The aim of this study was to evaluate the effects of drinking hydrogen-rich water on broiler growth performance, antioxidant capacity, meat quality, and cecum microbiota, with the objective of assessing its potential as a beneficial component in broiler production. Broilers were provided either hydrogen-rich water or regular taping water throughout the experimental period of 1 to 42 days. On day 42, six birds from each treatment group were selectively chosen for slaughter and subsequent dissection. Results: The results indicated that the administration of hydrogen-rich water had no significant effect on the growth performance of broilers. However, compared to the control group, the broilers receiving hydrogen-rich water group exhibited significantly higher levels of serum total antioxidant capacity (T-AOC) and superoxide dismutase activity (T-SOD). Moreover, the hydrogen-rich water group displayed significantly lower levels of reactive oxygen species (ROS) and malondialdehyde (MDA) in the liver, along with significantly higher catalase activity (CAT) compared to the control group. Regarding meat quality, the hydrogen-rich water group showed a significantly lower shearing force of chicken breast compared to the control group. Additionally, the proportions of leucine, lysine, and essential amino acids in chicken breast meat were significantly higher in the hydrogen-rich water group. Conversely, the percentage of undecanoic acid in chicken breast meat was significantly lower in the hydrogen-rich water group compared to the control group. Furthermore, the percentages of palmitoleic acid, oleic acid, erucic acid, γ-Linolenic acid, α-Linolenic acid, and monounsaturated fatty acids in chicken breast meat were significantly higher in the hydrogen-rich water group compared to the control group. In terms of cecum microbiota, no significant differences were observed between the two groups in terms of α diversity, β diversity, and phylum species composition. However, at the genus level, the relative abundance of Mediterraneibacter, Kineothrix, Roseburia, Stenotrophomonas, and Proteobacteria_Unclassifiedin the hydrogen-rich water group was significantly higher compared to the control group. On the other hand, the relative abundance of Ralstoniaand Symbiobacterium was significantly lower in the hydrogen-rich water group compared to the control group. Conclusion: In summary, the results of this study highlight the beneficial effects of hydrogen-rich water on antioxidant parameters in the serum and liver of broilers. It also suggests its potential improving the quality and composition of amino acids and fatty acids in broiler breast meat. Additionally, hydrogen-rich water appears to have a significant impact on the cecum microbiota of broilers.

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“…In addition, many animal models have also verified these effects of H 2 by drinking hydrogen-rich water. Hydrogen-rich water slows the intestinal barrier function in a mouse model of inflammatory bowel disease induced by sodium dextran sulfate (Ge et al 2022 ; Song et al 2022 ). Also, the consumption of hydrogen-enriched water increased the SCFAs-producing microbes ( Lachnospiraceae , Rikenellaceae , and Prevotella ) in the intestine.…”

Section: Role Of Metabolites In the Intestinal Tractmentioning

confidence: 99%

In vitro and in vivo fermentation models to study the function of dietary fiber in pig nutrition

Huangfu,

Cao,

et al. 2024

Appl Microbiol Biotechnol

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The importance of dietary fiber (DF) in animal diets is increasing with the advancement of nutritional research. DF is fermented by gut microbiota to produce metabolites, which are important in improving intestinal health. This review is a systematic review of DF in pig nutrition using in vitro and in vivo models. The fermentation characteristics of DF and the metabolic mechanisms of its metabolites were summarized in an in vitro model, and it was pointed out that SCFAs and gases are the important metabolites connecting DF, gut microbiota, and intestinal health, and they play a key role in intestinal health. At the same time, some information about host-microbe interactions could have been improved through traditional animal in vivo models, and the most direct feedback on nutrients was generated, confirming the beneficial effects of DF on sow reproductive performance, piglet intestinal health, and growing pork quality. Finally, the advantages and disadvantages of different fermentation models were compared. In future studies, it is necessary to flexibly combine in vivo and in vitro fermentation models to profoundly investigate the mechanism of DF on the organism in order to promote the development of precision nutrition tools and to provide a scientific basis for the in-depth and rational utilization of DF in animal husbandry. Key points • The fermentation characteristics of dietary fiber in vitro models were reviewed. • Metabolic pathways of metabolites and their roles in the intestine were reviewed. • The role of dietary fiber in pigs at different stages was reviewed. Graphical Abstract

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Hydrogen-rich water partially alleviate inflammation, oxidative stress and intestinal flora dysbiosis in DSS-induced chronic ulcerative colitis mice

Cited by 17 publications

References 38 publications

Quinic acid ameliorates ulcerative colitis in rats, through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways

Quinic acid ameliorates ulcerative colitis in rats, through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways

Effects of hydrogen-rich water on antioxidant capacity, meat quality and cecum mic robiota of broiler chickens

In vitro and in vivo fermentation models to study the function of dietary fiber in pig nutrition

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