Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice

Zhao, Ming; Liu, Mingdong; Pu, Yingyan; Wang, Dan; Xie, Yonggang; Xue, Gaici; Jiang, Yong; Yang, Qianqian; Sun, Xuejun; Cao, Li

doi:10.1016/j.jneuroim.2016.03.006

Cited by 18 publications

(7 citation statements)

References 45 publications

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“…A recent study showed that H 2 administration without surgery did not exert neuroprotective effects or improve functional outcomes in rats after intracerebral hemorrhage [ 109 ]. For spinal cord injury, H 2 treatment improved locomotor behavior recovery in rats [ 110 ] and neurological recovery in mice with experimentally-induced autoimmune encephalomyelitis [ 111 ].…”

Section: Preventive and Therapeutic Applications Of Hmentioning

confidence: 99%

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

et al. 2017

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Since the 2007 discovery that molecular hydrogen (H2) has selective antioxidant properties, multiple studies have shown that H2 has beneficial effects in diverse animal models and human disease. This review discusses H2 biological effects and potential mechanisms of action in various diseases, including metabolic syndrome, organ injury, and cancer; describes effective H2 delivery approaches; and summarizes recent progress toward H2 applications in human medicine. We also discuss remaining questions in H2 therapy, and conclude with an appeal for a greater role for H2 in the prevention and treatment of human ailments that are currently major global health burdens. This review makes a case for supporting hydrogen medicine in human disease prevention and therapy.

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Section: Preventive and Therapeutic Applications Of Hmentioning

confidence: 99%

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

et al. 2017

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“…EAE is the classic animal model for human multiple sclerosis. H 2 -rich water intervention could alleviate EAE symptoms through reducing CD4+ T cell infiltration and inhibiting Th17 cell differentiation in the spinal (Zhao et al, 2016 ). For immune deficiency, different concentrations of H 2 can improve the immunodeficiency state and antitumor immune function by increasing the proportion of CD8+ T cells (Akagi and Baba, 2019 ).…”

Section: Biological Effects Of Hydrogenmentioning

confidence: 99%

Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis

et al. 2021

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Molecular hydrogen (H2) is a colorless and odorless gas. Studies have shown that H2 inhalation has the therapeutic effects in many animal studies and clinical trials, and its application is recommended in the novel coronavirus pneumonia treatment guidelines in China recently. H2 has a relatively small molecular mass, which helps it quickly spread and penetrate cell membranes to exert a wide range of biological effects. It may play a role in the treatment and prevention of a variety of acute and chronic inflammatory diseases, such as acute pancreatitis, sepsis, respiratory disease, ischemia reperfusion injury diseases, autoimmunity diseases, etc.. H2 is primarily administered via inhalation, drinking H2-rich water, or injection of H2 saline. It may participate in the anti-inflammatory and antioxidant activity (mitochondrial energy metabolism), immune system regulation, and cell death (apoptosis, autophagy, and pyroptosis) through annihilating excess reactive oxygen species production and modulating nuclear transcription factor. However, the underlying mechanism of H2 has not yet been fully revealed. Owing to its safety and potential efficacy, H2 has a promising potential for clinical use against many diseases. This review will demonstrate the role of H2 in antioxidative, anti-inflammatory, and antiapoptotic effects and its underlying mechanism, particularly in coronavirus disease-2019 (COVID-19), providing strategies for the medical application of H2 for various diseases.

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“…HRW memiliki kandungan hidrogen sebesar 0,55-0,65 mM (Nakao et al, 2010). HRW dipilih karena harganya murah, mudah didapatkan, tidak mengandung senyawa kimia yang berbahaya dan memiliki manfaat antara lain antikanker dan pencegah alzaimer (Zhao et al, 2016;Tian et al, 2016). Pemanfaatan HRW selama ini hanya digunakan pada bidang kesehatan, belum pernah diaplikasikan untuk bahan pangan.…”

Section: Pendahuluanunclassified

Aplikasi Hydrogen Rich Water Pada Modifikasi Tepung Kentang Dengan Pengering Gelombang Mikro Sebagai Alternatif Substitusi Gandum

Budiarti

Sulistiawati

2019

EKW

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Kentang merupakan umbi tinggi mineral dapat digunakan sebagai bahan alternatif substitusi gandum. Namun, kentang memiliki daya kembang yang rendah dibandingkan gandum. Sehingga dilakukan modifikasi menggunakan hydrogen rich water yang aman untuk makanan dibantu dengan pengering gelombang mikro. Penelitian ini bertujuan untuk mengetahui pengaruh hydrogen rich water terhadap sifat fisikokimia tepung kentang yaitu swelling power, kelarutan, viskositas dan morfologi tepung kentang. Variasi waktu perendaman modifikasi pati dan pH yang digunakan adalah 10, 20, 30, dan 40 menit dan 9, 5. Dari hasil yang diperoleh, perlakuan yang direkomendasikan adalah waktu perendaman 30 menit dan pH 5 dengan nilai swelling power, kelarutan dan viskositas masing-masing 12,51 g/g, 2,28%, dan 1,14 cP. Analisis Scanning Electron Microsopy (SEM) menunjukkan morfologi pati yang telah dimodifikasi kasar dan menyatu. Hasil yang diperoleh lebih tinggi daripada nilai dari tepung terigu. Sehingga kentang dapat dipertimbangkan sebagai bahan alternatif substitusi terigu.

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Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice

Cited by 18 publications

References 45 publications

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis

Aplikasi Hydrogen Rich Water Pada Modifikasi Tepung Kentang Dengan Pengering Gelombang Mikro Sebagai Alternatif Substitusi Gandum

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