Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture

Zhou, Jun; Chen, Ye; Huang, Gailing; Li, Jun; Wu, Gen-Cheng; Liu, Li; Bai, Yiping; Wang, Jian

doi:10.1016/j.jss.2012.01.041

Cited by 42 publications

(28 citation statements)

References 42 publications

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“…Brain slices derived from mice administered hydrogen-rich pure water for 33 days showed significantly less superoxide formation than the control [35]. In a rat model of sepsis, the intraperitoneal administration of hydrogen-rich saline inhibited the increase of oxidative responses, such as ROS and malondialdehyde, in the hippocampus in a dose-dependent manner [43]. Also, drinking HW significantly suppressed intimal hyperplasia of the inferior vena cava in the rat [12].…”

Section: Discussionmentioning

confidence: 99%

Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses

Tsubone

Hanafusa

Endo

et al. 2013

JES

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The present study aimed to clarify changes of oxidative stress and antioxidative functions in treadmill-exercised Thoroughbred horses (n=5, 3 to 7 years old), using recently developed techniques for measurement of serum d-ROMs for oxidative stress, and BAP for antioxidative markers. Also, the effect of nasogastric administration of hydrogen-rich water (HW) or placebo water preceding the treadmill exercise on these parameters was examined. Each horse was subjected to a maximum level of treadmill exercise in which the horses were exhausted at an average speed of 13.2 ± 0.84 m/sec. Blood samples were taken 4 times, immediately before the intake of HW or placebo water at 30 min preceding the treadmill exercise, immediately before the exercise (pre-exercise), immediately after the exercise (post-exercise) and at 30 min following the exercise. In all horses, both d-ROMs and BAP values significantly increased at post-exercise. The increase in d-ROMs tended to be lower in the HW trial, as compared to the placebo trial at pre-exercise. The increase in BAP was considerable at approximately 150% of the pre-exercise values in both the HW and placebo treatment trials. The BAP/d-ROMs ratio was significantly elevated at post-exercise in both treatment trials, while a significant elevation was also observed at pre-exercise in the HW trial. BAP, d-ROM, and the BAP/d-ROM ratio tended to decline at 30 min after the exercise, except BAP and BAP/d-ROMs in the placebo trial. These results demonstrate that the marked elevation of oxidative stress and anitioxidative functions occurred simultaneously in the intensively exercised horses, and suggest a possibility that HW has some antioxidative efficacy.

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Section: Discussionmentioning

confidence: 99%

Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses

Tsubone

Hanafusa

Endo

et al. 2013

JES

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“…Similarly, hydrogen-rich saline has potential protective effects against sepsis by decreasing proinflammatory responses, oxidative stress, and apoptosis in a rat model of polymicrobial sepsis [45]. In addition, hydrogen-rich saline markedly reverses cognitive impairment and mortality in a dose-dependent manner in rats submitted to sepsis by cecal ligation and puncture, which are relative to the suppression of oxidative stress and cell apoptosis [101]. …”

Section: Hydrogen-rich Saline Exerts the Same Therapeutic Effect Wmentioning

confidence: 99%

Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis

Xie

Liu

et al. 2014

BioMed Research International

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Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen is a new therapeutic gas. Our studies have found that hydrogen gas can improve the survival and organ damage in mice and rats with cecal ligation and puncture, zymosan, and lipopolysaccharide-induced sepsis. The mechanisms are associated with the regulation of oxidative stress, inflammatory response, and apoptosis, which might be through NF-κB and Nrf2/HO-1 signaling pathway. In this paper, we summarized the progress of hydrogen treatment in sepsis.

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“…Previous studies have established that inflammatory cytokine release and oxidative stress injury are major pathophysiological mechanisms of sepsis, resulting in injury to system tissues and organs [3,4]. Further studies have shown that the mechanisms underlying sepsis are related to cytokine generation and oxidative stress injury [3,5].…”

Section: Introductionmentioning

confidence: 99%

Insulin alleviates the inflammatory response and oxidative stress injury in cerebral tissues in septic rats

Chen

Shi

et al. 2014

J Inflamm

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Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction that occurs secondary to infection in the body without overt central nervous system (CNS) infection. SAE is frequently encountered in critically ill patients in intensive care units and can be detected in up to 50–70% of septic patients. Previous studies have demonstrated that inflammatory cytokine release and oxidative stress injury are major pathophysiological mechanisms of SAE in critically ill patients. However, there are no effective strategies for the treatment of SAE. Insulin has important immunomodulatory effects and protective effects against oxidative stress injury in the peripheral organs of septic patients. However, very few studies of the possible effects of insulin in cerebral tissues of septic patients have been reported. Therefore, in this study, we aimed to explore whether insulin therapy can inhibit cytokine production (IL-1, IL-6, and TNF-a) and oxidative stress injury of the brain tissue in septic rats. We observed that the protein concentrations of IL-1, IL-6, and TNF-а, in addition to MDA and H2O2 were notably increased, inversely SOD, and GSH were sigificantly decreased in cortex, hippocampus, and hypothalamus of septic rats. Furthermore, the levels of S100 and NSE significantly increased. After 6 hours of insulin therapy, we found that the cytokine concentrations notably decreased and oxidative stress injuries in the cortex, hypothalamus, and hippocampus were alleviated in septic rats. In addition, the S100 and NSE levels significantly decreased. We concluded that insulin can inhibit the production of inflammatory cytokines and the oxidative stress response, thereby improving brain tissue damage.

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Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture

Cited by 42 publications

References 42 publications

Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses

Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses

Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis

Insulin alleviates the inflammatory response and oxidative stress injury in cerebral tissues in septic rats

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