Hydrogen peroxide treatment in Atlantic salmon induces stress and detoxification response in a daily manner

Vera, Luisa María; Migaud, Hervé

doi:10.3109/07420528.2015.1131164

Cited by 48 publications

(47 citation statements)

References 45 publications

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“…In addition, the present study provided new evidence on the circadian regulation of detoxification mechanisms in zebrafish, revealing that both detoxification genes and key transcription factors regulating their expression displayed rhythmicity. Recent research in fish demonstrated the chronotoxicity of anaesthetics (Sánchez-Vázquez et al, 2011;Vera et al, 2010;Vera et al, 2013b) and aquaculture medicines (Vera & Migaud, 2016). However, the molecular mechanisms underlying the temporal variations in toxicity and/or effectiveness of these compounds remained unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Previous research in fish species revealed that the time of exposure to hydrogen peroxide caused time-dependent differences in the induction of detoxification genes, being higher in the middle of the light phase (Vera & Migaud, 2016). On the other hand, the exposure of zebrafish to anaesthetics (MS-222 and eugenol) resulted in higher toxicity to fish when trials were carried out in the middle of the light phase (ML) in comparison to mid-darkness (MD) (Sánchez-Vázquez et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

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Light- and clock-control of genes involved in detoxification

Carmona‐Antoñanzas

Santi

Migaud

et al. 2017

Chronobiology International

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25Circadian regulation of hepatic detoxification seems to be amongst the key roles of the 26 biological clock. The liver is the major site for biotransformation, and in mammals, it 27 contains several clock-controlled transcription factors such as PAR basic leucine zipper 28 proteins (bZIP) and basic-helix-loop-helix (bHLH)-PAS family that act as circadian 29 regulators of detoxification genes. This investigation explored the existence of daily and 30 circadian expression of transcription factors involved in detoxification, as well as the 31 temporal profile of a set of their target genes in zebrafish liver. In our study, zebrafish were 32 able to synchronize to a light-dark (LD) cycle and displayed a diurnal pattern of activity. In 33 addition, the expression of clock genes presented daily and circadian rhythmicity in liver. 34Apart from hlfa, the expression of PAR bZIP transcription factors also displayed daily 53showed that time of day should be considered when designing toxicological studies or 54 administering drugs to fish.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Light- and clock-control of genes involved in detoxification

Carmona‐Antoñanzas

Santi

Migaud

et al. 2017

Chronobiology International

Self Cite

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“…Current bathing procedures negatively affect the health and welfare of fish through withholding feed prior to, and crowding and oxygen deprivation during, bathing (Burka et al . ; Conte ; Vera & Migaud ). Among aquaculturists, there is an unspoken understanding that it is the treatment, and not the sea lice, that causes many of the large‐scale mortality events (Svåsand et al .…”

Section: Drawbacks Of the Current Toolsmentioning

confidence: 99%

“…In addition to broader environmental concerns over the use of chemotherapeutants (Burridge et al 2010), a less publicised issue is the welfare implications of chemotherapeutants to the salmon themselves. Current bathing procedures negatively affect the health and welfare of fish through withholding feed prior to, and crowding and oxygen deprivation during, bathing (Burka et al 1997;Conte 2004;Vera & Migaud 2016). Among aquaculturists, there is an unspoken understanding that it is the treatment, and not the sea lice, that causes many of the large-scale mortality events (Sv asand et al 2016).…”

Section: Drawbacks Of the Current Toolsmentioning

confidence: 99%

Behaviour in the toolbox to outsmart parasites and improve fish welfare in aquaculture

Bui

Oppedal

Sievers

et al. 2017

Reviews in Aquaculture

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Host behaviour can prevent infection and moderate the fitness of parasites. Antiparasite behaviours are prevalent in many host–parasite systems and occur over fine or broad scales. With global growth in aquaculture production and the associated proliferation of parasites in farming systems, the behaviour of the fish being farmed has seldom been investigated in relation to parasites. Epidemics and outbreaks of parasites are prevalent in most aquaculture systems, and behaviour could be harnessed in concert with current methods to prevent and control parasites and pathogens. However, this requires a systematic understanding of the behaviours of hosts, their capacity for resistance and their interaction with the environment and the parasite. Herein, we present evidence for how behaviour could be used in aquaculture, and discuss the possibility for behaviour to be used in aquaculture as (i) an indicator of welfare status, (ii) a tool in prevention or control and (iii) to maintain or improve welfare. We apply this framework to a case study of a highly problematic parasite, the salmon louse (Lepeophtheirus salmonis), on farmed Atlantic salmon (Salmo salar). We present the current state of the system, and the drawbacks of current control or prevention methods. We synergise current knowledge on host behaviours and show how behaviour could be incorporated into current and new approaches for prevention and control. Through this first evaluation of the possibilities behaviour presents in disease management, we aim to facilitate a shift in the current disease control paradigm from reactive‐based post‐infection control to pre‐infection prevention approaches.

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“…Additionally, when in the aquatic environment H 2 O 2 breaks down quickly (1–10 days) into water and oxygen, therefore leaving no toxic by-products and making it reasonably environmentally friendly [ 17 , 23 , 24 ]. However, concerns have been raised regarding fish welfare during exposure to this chemical and it has been reported to cause stress in Atlantic salmon in the first 24 h post-exposure [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative ploidy response to experimental hydrogen peroxide exposure in Atlantic salmon (Salmo salar)

Chalmers

Vera

Taylor

et al. 2018

Fish & Shellfish Immunology

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While research into the growth, survival, nutrition and, more recently, disease susceptibility of triploid Atlantic salmon has expanded, there remains an overall lack of studies assessing the response of triploids to chemical treatments. It is essential that the response of triploids to disease treatments be characterised to validate their suitability for commercial production. This study aimed to investigate and compare the stress and immune responses of triploid and diploid Atlantic salmon following an experimental treatment with hydrogen peroxide (H2O2). A dose response test was first undertaken to determine a suitable test dose for both diploid and triploid Atlantic salmon. Following this, diploids and triploids were exposed to H2O2 (1800 ppm) for 20 min, as per commercial practices, after which blood glucose and lactate, and plasma cortisol and lysozyme were measured, along with the expression of oxidative stress and immune-related genes. In the first 6 h post-exposure to H2O2, comparable mortalities occurred in both diploid and triploid Atlantic salmon. Cortisol, glucose and lactate were not significantly influenced by ploidy suggesting that, physiologically, triploid Atlantic salmon are able to cope with the stress associated with H2O2 exposure as well as their diploid counterparts. Exposure to H2O2 significantly elevated the expression of cat and sod2 in diploid livers and gr, il1β and crp/sap1b in diploid gills, while it significantly decreased the expression of saa5 and crp/sap1a in diploid gills. In triploids, the expression levels of cat, hsp70, sod1, saa5, crp/sap1a and crp/sap1b in liver was significantly higher in fish exposed to H2O2 compared to control fish. The expression of gr, sod1 and il1β in triploid gills was also elevated in response to H2O2 exposure. This study represents the first experimental evidence of the effects of H2O2 exposure on triploid Atlantic salmon and continues to support their application into commercial production.

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Hydrogen peroxide treatment in Atlantic salmon induces stress and detoxification response in a daily manner

Abstract: 19Daily variation in the absorption, metabolism and excretion of toxic substances will 20 ultimately determine the actual concentration to which the cells and tissues are exposed. In 21 aquaculture, Atlantic salmon (Salmo salar) can be frequently exposed to hydrogen peroxide

Cited by 48 publications

References 45 publications

Light- and clock-control of genes involved in detoxification

Light- and clock-control of genes involved in detoxification

Behaviour in the toolbox to outsmart parasites and improve fish welfare in aquaculture

Comparative ploidy response to experimental hydrogen peroxide exposure in Atlantic salmon (Salmo salar)

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