Hydrogen Peroxide Sensors for Biomedical Applications

Abstract

Hydrogen peroxide (H2O2) is an important molecule within the human body, but many of its roles in physiology and pathophysiology are not well understood. To better understand the importance of H2O2 in biological systems, it is essential that researchers are able to quantify this reactive species in various settings, including in vitro, ex vivo and in vivo systems. This review covers a broad range of H2O2 sensors that have been used in biological systems, highlighting advancements that have taken place since 2015.

Synthesis of Silver and Gold Nanoparticles from Rumex roseus Plant Extract and Their Application in Electrochemical Sensors

“…Here, we have investigated the sensing properties of the synthesized AgNPs and AuNPs with the aim to develop electrochemical sensors by using these nanoparticles as modifiers of glassy carbon electrode (GCE) and screen-printed carbon electrode (SPCE), for the monitoring of hydrogen peroxide (H 2 O 2 ) and Riboflavin (Vitamin B2, RF), respectively. H 2 O 2 is an important molecule within the human body, playing various roles in physiological processes, where it regulates cell growth, whereas, at high levels, H 2 O 2 can be detrimental, causing inflammation and cell damage [ 17 ]. Riboflavin is essential for the development of infant tissues, the function of the muscles, heart, the nervous system and mental activity [ 18 ].…”

A Highly Sensitive and Selective Non‐enzymatic Hydrogen Peroxide Sensor Based on Nanostructured Co3O4 Thin Films Using the Sol‐gel Method

“…The as‐obtained material presents a wide linear range from nanomolar to millimolar (50 nM to 1100 mM) which is useful for industrial applications. Indeed, electrochemical sensors detecting both low and high analyte concentrations are highly requested in the biological fields [16, 17]. Similarly, the thin films studied in this work exhibit a sensitivity of 1450 μM, which is among the highest for the Co 3 O 4 nanomaterials cited in the literature [18–21].…”

A Brief Review of How to Construct an Enzyme-Based H<sub>2</sub>O<sub>2</sub> Sensor Involved in Nanomaterials

“…Such single-use electrode strips are mass produced by the rapid and simple thick-film microfabrication or vapor deposition process. In these devices each strip contains both printed working and reference electrodes in which the working one is coated with the needed reagents such as enzyme, mediator, stabilizer, surfactant, linking, and binding agents and membranes as shown in figure below [1]. Most of these devices count on a ferricyanide mediator, except for the Abbott devices that employ a ferrocene derivative or an osmium-based redox polymer.…”

“…To diagnose and manage the diabetes mellitus, a closed surveillance of levels of blood glucose is required and the higher number of diabetics tests performed every day has made glucose to be most frequently analyte. This giant work has stimulating scientists to develop new biosensing concepts and a glucose biosensor based on enzyme were designed to make ease-to-use blood sugar testing and expecting their similar importance in continuous glucose monitoring [1] [2]. It is in this regard that enzyme based hydrogen peroxide electrodes have been widely developed and used glucose oxidase in the presence of oxygen for glucose measurements.…”