Hydrogen peroxide-promoted metal free oxidative amidation of 2-oxoaldehydes: a facile access to unsymmetrical oxamides

A novel acid-catalyzed rearrangement of 2-substituted-3-(2-nitrophenyl)oxiranes for the synthesis of di- and mono-oxalamides

“…33 The h method is a novel one and is based on green H 2 O 2promoted oxidative amidation of 2-oxoaldehydes with amines. 34 Nevertheless, these methods have several drawbacks, such as harsh conditions, expensive reagents, poor atom-efficiency and limited substrate scope. Method proposed in this study demonstrated a new, efficient and metal-free synthesis of unsymmetrical oxalamides via novel rearrangement of easily available 3-(2-nitroaryl)-oxirane-2-carboxamides.…”

Oxamide Derivatives as Potent α‐Glucosidase Inhibitors: Design, Synthesis, In Vitro Inhibitory Screening and In Silico Docking Studies

“…[1][2][3][4][5][6][7][8][9] Oxamide, a unique representative of amide, also have gained significant interest due to a variety of their applications in medicine, catalysis, magnetism, anticancer, antiproliferative, and antiinflammatory activities. [10][11][12][13][14][15] Most of the oxamides have also significant biological importance and inhibit several enzymes such as HIV-I protease, aldose reductase, tumor necrosis factor, [16][17][18][19][20][21][22] complement component 5a (C5a), [23] acetylcholinesterase, [24] anti-HIV, [25][26][27] HIV integrase, [28][29][30][31] as well as nitric oxide synthase, [32] and also play an important role in antiepileptic drugs. [33] This is mainly due to the presence of active amide group that is profoundly used in drug synthesis and natural product chemistry.…”

IBX-promoted domino reaction of α-hydroxy amides: a facile one-pot synthesis of isatins

“…21 And recently, several IBX or IBX analogues based methodology in water/organic solvent biphasic system has been established. 22 From last year, we have been focusing on the application of a-formyl amides 23 which can be easily synthesized from a-hydroxy amides via Swern oxidation. Although Li et al developed a copper-catalyzed intramolecular C-H oxidation/ acylation protocol for the synthesis of isatins from a-formyl amides (Scheme 1a), 24 the synthetic method for isatins using a-hydroxy amides as starting materials hasn't been reported before.…”