“…[1][2][3][4][5][6][7][8][9] Oxamide, a unique representative of amide, also have gained significant interest due to a variety of their applications in medicine, catalysis, magnetism, anticancer, antiproliferative, and antiinflammatory activities. [10][11][12][13][14][15] Most of the oxamides have also significant biological importance and inhibit several enzymes such as HIV-I protease, aldose reductase, tumor necrosis factor, [16][17][18][19][20][21][22] complement component 5a (C5a), [23] acetylcholinesterase, [24] anti-HIV, [25][26][27] HIV integrase, [28][29][30][31] as well as nitric oxide synthase, [32] and also play an important role in antiepileptic drugs. [33] This is mainly due to the presence of active amide group that is profoundly used in drug synthesis and natural product chemistry.…”