Hydrogen peroxide filled poly(methyl methacrylate) microcapsules: Potential oxygen delivery materials

Abstract

This paper describes the synthesis of H₂O₂-H₂O filled poly(methyl methacrylate) (PMMA) microcapsules as potential candidates for controlled O₂ delivery. The microcapsules are prepared by a water-in-oil solvent emulsion and evaporation method. The results of this study describe the effect of process parameters on the characteristics of the microcapsules and on their in vitro performance. The size of the microcapsules, as determined from scanning electron microscopy, ranges from ∼5 to 30 μm and the size distribution is narrow. The microcapsules exhibit an internal morphology with entrapped H₂O₂-H₂O droplets randomly distributed in the PMMA continuous phase. In vitro release studies of 4.5 wt% H₂O₂-loaded microcapsules show that ∼70% of the H₂O₂ releases in 24h. This corresponds to a total O₂ production of ∼12 cc/gram of dry microcapsules. Shelf-life studies show that the microcapsules retain ∼84 wt% of the initially loaded H₂O₂ after nine months storage at 2-8 °C, which is an attractive feature for clinical applications.

Fluorinated Methacrylamide Chitosan Hydrogels Enhance Cellular Wound Healing Processes

“…Oxygenated MACF gels have several benefits over other oxygenating approaches such as oxygen generating biomaterials employing calcium peroxide, 27 hydrogen peroxide 20 and sodium per carbonate. 37 Chiefly, as discussed in the introduction, these generation approaches have downsides which may lead to the further death of cells.…”

Oxygen delivering biomaterials for tissue engineering

“…The most heavily investigated oxygen generating biomaterials involve the decomposition of hydrogen peroxide into molecular oxygen directly, in the case of hydrogen peroxide, 62–65 or through following dissolution of solid peroxides, in the cases of sodium percarbonate 66–68 and calcium peroxide. 67,69,70 Sodium percarbonate is a solid adduct of sodium carbonate and hydrogen peroxide that decomposes into ions and hydrogen peroxide in aqueous solution.…”

Control of oxygen release from peroxides using polymers

“…A potential solution for the lack of oxygen may be the use of composite oxygen-delivering scaffold materials, with peroxide salts as source of oxygen [2]. These materials should deliver oxygen to cells or tissue for a prolonged period of time such that implanted cells survive and contribute to tissue repair, but without interfering with angiogenesis, which is induced in hypoxic conditions [3][4][5][6][7]. Such composites should provide cell survival throughout the scaffold, thereby improving tissue restoration or repair.…”

“…The reaction intermediate, hydrogen peroxide is considered to be a cytotoxic agent. Mammalian cells have several defence mechanisms to help convert H 2 O 2 into oxygen and water and can deal with low concentrations of hydrogen peroxide [7].…”