Hydrogen Peroxide Affects the Electroretinogram of Isolated Perfused Rat Retina

Jacquemot, Nathalie; Wersinger, Eric; Brabet, Philippe; Cia, David

doi:10.1080/02713683.2023.2256029

Cited by 1 publication

(1 citation statement)

References 42 publications

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“…Ischemia–reperfusion injury and, similarly, oxidative stress (e.g., by H 2 O 2 ) are known to increase the latency times (i.e., implicit times) of a- and b-waves in the electroretinogram [ 44 , 45 , 46 ]. This was evident in our electroretinographical measurements as well.…”

Section: Discussionmentioning

confidence: 99%

Electroretinographical Analysis of the Effect of BGP-15 in Eyedrops for Compensating Global Ischemia–Reperfusion in the Eyes of Sprague Dawley Rats

Takács,

Szilágyi,

Priksz

et al. 2024

Biomedicines

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Retinal vascular diseases and consequential metabolic disturbances in the eye are major concerns for healthcare systems all around the world. BGP-15, a drug candidate small-molecule [O-(3-piperidino-2-hydroxy-1-propyl) nicotinic amidoxime dihydrochloride], has been formerly demonstrated by our workgroup to be retinoprotective both in the short and long term. Based on these results, the present study was performed to investigate the efficacy of BGP in an eyedrop formulation containing sulfobutylether-β-cyclodextrin (SBECD), which is a solubility enhancer as well. Electroretinographical evaluations were carried out and BGP was demonstrated to improve both scotopic and photopic retinal a- and b-waves, shorten their implicit times and restore oscillatory potentials after ischemia–reperfusion. It was also observed to counteract retinal thinning after ischemia–reperfusion in the eyes of Sprague Dawley rats. This small-molecule drug candidate is able to compensate for experimental global eye ischemia–reperfusion injury elicited by ligation of blood vessels in rats. We successfully demonstrated that BGP is able to exert its protective effects on the retina even if administered in the form of eyedrops.

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Section: Discussionmentioning

confidence: 99%