Hydrogen Peroxide – A Party Trick from the Past?

“…It has been reported that hydrogen peroxide (100 mg/kg body weight) induced alternations in antioxidant enzyme activity in mice (Yalçın et al 2020 ). In normal conditions, the glutathione/glutathione peroxidase system maintains the hydrogen peroxide levels by breaking down to oxygen and water (Reid et al 2011 ). In this study, antioxidant levels (reduced glutathione and GPx) after exposure to 0.5% hydrogen peroxide mist were assessed; no significant difference was observed in reduced glutathione and GPx activity in all study group animals exposed to 0.5% of H 2 O 2 mist, at a concentration of 11.022 (low dose—2-min exposure), 22.044 (medium dose—4-min exposure), and 55.11 mg/kg body weight (high dose/high dose recovery—10-min exposure), daily for 7 days with respect to control.…”

Section: Discussionmentioning

confidence: 99%

Safety of 0.5% hydrogen peroxide mist used in the disinfection gateway for COVID-19

Mohanan

Sangeetha

Sabareeswaran

et al. 2021

Environ Sci Pollut Res

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Hydrogen peroxide (H 2 O 2 ) is a reactive chemical used in a wide range of applications. Most importantly, it is used for sterilization process in health care environment. In the present study, safety assessment of 0.5% of H 2 O 2 and its mist intended to be used in the disinfection gateway for COVID-19 was evaluated. Skin irritation and repeated-dose inhalation toxicity studies were carried out in rabbits and rats, respectively. In Skin irritation study, New Zealand white rabbits were exposed topically with 0.5% H 2 O 2 solution and observed for 24 h, 48 h, and 72 h. For repeated-dose inhalation toxicity study, Wistar rats (both male and female) were exposed (whole body exposure) to 0.5% of H 2 O 2 mist, at a concentration of 11.022 (low dose—2-min exposure), 22.044 (medium dose—4-min exposure), and 55.11mg/kg (high dose/high dose recovery—10-min exposure) body weight, daily for 7 days. Rats in the high-dose recovery group (55.11mg/kg—10-min exposure) were kept for another 7 days without any exposure. A toxicological evaluation was done based on general health parameters, hematology, serum biochemistry, gross necropsy, and histopathological data. The results of the study indicated that there was no skin irritation potential induced on exposure of 0.5% of H 2 O 2 to rabbits. Similarly, the inhalation toxicity of 0.5% of H 2 O 2 mist imparts no evidence of hematological, biochemical, gross pathology, or histopathological abnormalities in rats. Further, at the laboratory condition stimulated, the NOEL was found to be 55.11mg/kg body weight. Hence, the present study concluded that 0.5% H 2 O 2 or its mist used in the disinfection gateway for COVID-19 failed to induce any skin irritation in rabbits or inhalation toxicity in rats. Graphical abstract

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“…Although 3% hydrogen peroxide solution is routinely used to disinfect wounds, it has not been found to have any beneficial effect in wound healing. In fact, its use has been associated with significant risk and should be reconsidered (Reid et al, 2011). While hydrogen peroxide is thought to kill pathogens through cell burst, it is also toxic to tissue.…”

Section: Discussionmentioning

confidence: 99%

Pharmacy students’ beliefs in popular myths about health and therapy

Jasińska-Stroschein

Kurczewska

Orszulak–Michalak

2019

Health Education Journal

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Objective: Pharmacy students are among the next generation of health-care providers who can promote medical knowledge based on scientific data or low-quality health content. Their susceptibility to popular myths related to health and medicine however threatens the proper selection and use of the best available evidence when dealing with patients in community and hospital pharmacies. The objective of this study was to explore such beliefs held by pharmacy students. Methods: A self-administered survey was completed by a sample of 195 Polish pharmacy students (years 1 and 2 as well as years 4 and 5). The students ranked their attitudes towards 36 popular mythical statements on a scale of ‘strongly disagree’ (1 point) to ‘strongly agree’ (5 points). The respondents gave fewer than half the correct answers regarding both general knowledge and more specialised pharmacy knowledge. Results: We explore some of the statements that were not influenced by the education process. The important determinants of student susceptibility to myths about pharmacy and therapy were year of study and preferred sources of scientific information, including the language used in these sources. Conclusion: More attention should be given to evidence-based medicine skills, including the selection of proper scientific information and the adoption of a critical perspective towards all transmitted information among student pharmacists. This approach would reduce the risk of future pharmacists, as care providers, popularising potentially harmful health myths and misconceptions when educating their patients.

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Hydrogen Peroxide – A Party Trick from the Past?

Cited by 12 publications

References 81 publications

Bedside to bench: re‐thinking nursing research

Bedside to bench: re‐thinking nursing research

Safety of 0.5% hydrogen peroxide mist used in the disinfection gateway for COVID-19

Pharmacy students’ beliefs in popular myths about health and therapy

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