Hydrogen Peroxide 3% Exposures

Henry, Malcolm C.; Wheeler, John F.; Mofenson, Howard C.; Caraccio, Thomas R.; Mn, Marsh; Comer, Gail M.; Singer, Adam J.

doi:10.3109/15563659609013797

Cited by 46 publications

(38 citation statements)

References 17 publications

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“…In a study reviewing 670 exposures to 3% hydrogen peroxide, 77% of the exposures were by the oral route and half of the exposures occurred in children younger than 6 years old (10). All the cases did not show gas emboli and it resulted in only minor symptoms such as nausea and vomiting, except for one case.…”

Section: Discussionmentioning

confidence: 98%

Hemorrhagic gastritis and gas emboli after ingesting 3% hydrogen peroxide

Moon

Chun

Min

2006

The Journal of Emergency Medicine

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Section: Discussionmentioning

confidence: 98%

Hemorrhagic gastritis and gas emboli after ingesting 3% hydrogen peroxide

Moon

Chun

Min

2006

The Journal of Emergency Medicine

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“…Ingestions of 3% hydrogen peroxide are typically benign with mucosal toxicity being the most commonly reported sign (10). At concentrations of 30% or higher, ingestion of even small amounts of peroxide can be potentially fatal.…”

Section: Discussionmentioning

confidence: 99%

Cerebral air gas embolism from concentrated hydrogen peroxide ingestion

Rider

Jackson

Rusyniak

2008

Clinical Toxicology

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“…Although hydrogen peroxide toxicity is possible following ingestion of a 3% household strength solution, it becomes more likely as concentrations increase to those of industrial strength ( ≥35%). Bloody emesis and multiple ulcers of the gastric antrum were found in one case of a previously healthy 3-year-old child who ingested 180 mL of 3% hydrogen peroxide [11].…”

Section: Discussionmentioning

confidence: 99%

Ingestion of a denture cleanser: Did it cause gastric perforation?

Ingram

Baldwin

2008

J. Med. Toxicol.

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INTRODUCTIONEfferdent is a product designed to cleanse dentures in a container when added to water. The outside of the package clearly states in large, highlighted, capitalized letters: "Do not put tablets or solution directly in mouth." Despite this warning and similar ones found on other denture cleansing products, there were 1,512 reported exposures to denture cleanser products by the Toxic Exposure Surveillance System in 2005. Of these, 77% were in adults over 19 years old. Only 38 (2.5%) were intentional, 97.5% were accidental, 82 (5.4%) were treated in a healthcare facility, 8 (0.5%) were found to cause "moderate" complications, and only one resulted in death, though no further information is reported about this case [1]. CASE REPORTA 27-year-old man presented to an Emergency Department (ED) complaining of severe abdominal pain, diarrhea, and blood-tinged vomitus. Ten days prior the patient had been offered a job interview that required pre-employment urine drug testing. Because he had been smoking marijuana regularly, he followed a friend's suggestion to attempt manipulation of the cannabinoid assay through ingestion of Efferdent tablets. Seven days prior to presentation he ingested one tablet in a glass of water, which quickly resulted in abdominal pain. The following day he ingested two more tablets in water, which resulted in abdominal pain that continued to increase until presentation. He did not comment on whether the tablets were fully dissolved.The patient had no significant past medical or surgical history, took no medications, and had no allergies to medications. His family history was non-contributory. He denied any prior gastrointestinal symptoms. His social history was positive for tobacco abuse and negative for alcohol use.The patient's vital signs were: oral temperature, 36.1°C, heart rate 62 bpm, respiratory rate 18/minute, blood pressure 150/78 mmHg, and O 2 saturation 98% on room air. On physical examination, he was a thin male in moderate distress secondary to ABSTRACTIntroduction: Human ingestion of denture cleansers leading to gastric perforation has not previously been described. Case Report: A 27-year-old male ingested three denture cleanser tablets in water over two days in an attempt to cause a falsenegative result on a workplace urine drug screen. Seven days later he presented to an emergency department with a perforated gastric ulcer.Discussion: A literature review of cases and the chemistry of the components of his ingestion was conducted to determine the possible relationship between these events. Ingestion of intact fragments of the tablets would be likely to result in significant gastric toxicity, but ingestion of dissolved tablets would be unlikely to have caused his illness.

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Hydrogen Peroxide 3% Exposures

Abstract: Exposure to hydrogen peroxide 3% is usually benign, however, severe gastric injury may occur following small ingestions in children. Patients who report persistent vomiting or bloody emesis require medical evaluation and consideration of endoscopy to evaluate gastrointestinal injury.

Cited by 46 publications

References 17 publications

Hemorrhagic gastritis and gas emboli after ingesting 3% hydrogen peroxide

Hemorrhagic gastritis and gas emboli after ingesting 3% hydrogen peroxide

Cerebral air gas embolism from concentrated hydrogen peroxide ingestion

Ingestion of a denture cleanser: Did it cause gastric perforation?

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