Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial

Wei, Guan; Wei, Chun; Chen, Ai Lan; Sun, Xiao Cong; Guo, Guang Yun; Xu, Zhuobin; Shi, Jin; Lai, Pei Zhen; Zheng, Ze guang; Zhong, Nan

doi:10.21037/jtd-2020-057

Cited by 83 publications

(68 citation statements)

References 5 publications

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“…In summary, we hypothesize that the early use of hydrogen might mitigate the destruction caused by the cytokine storm associated with COVID-19, reducing lung injury, promoting viscous sputum drainage, and thus reducing the incidence of critically ill patients. Only one other article to date has mentioned the use of hydrogen to treat COVID-19 patients (Guan et al, 2020). In the future, more large-scale randomized controlled trials are needed to verify the efficacy and safety of this treatment clinically.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen: A Potential New Adjuvant Therapy for COVID-19 Patients

Yang¹,

Yue²,

Luo³

et al. 2020

Front. Pharmacol.

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Hydrogen has been shown to have antioxidant, anti-inflammatory, hormone-regulating, and apoptosis-resistance properties, among others. Based on a review of the research, the use of hydrogen might reduce the destructive cytokine storm and lung injury caused by SARS-CoV-2 during COVID-19 (Corona Virus Disease 2019) in the early stage, stimulating ropy sputum drainage, and ultimately reducing the incidence of severe disease. Molecular hydrogen treatment has the potential to become a new adjuvant therapy for COVID-19, but its efficacy and safety require large clinical trials and further confirmation.

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Section: Discussionmentioning

confidence: 99%

Hydrogen: A Potential New Adjuvant Therapy for COVID-19 Patients

Yang¹,

Yue²,

Luo³

et al. 2020

Front. Pharmacol.

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“…However, due to the low cost-effectiveness ratio, helium–oxygen mixed gas has not been extensively adopted in clinical practice. In contrast, hydrogen/oxygen mixed gas (H 2 –O 2 ) could be generated via the direct electrolysis of water with the use of a commercialized instrument, and could be adopted for home use [104] . H 2 –O 2 inhalation has recently been shown to markedly ameliorate dyspnea in patients with central airway stenosis [104] .…”

Section: Advances In Clinical Managementmentioning

confidence: 99%

Strategies and Advances in Combating COVID-19 in China

Liu¹,

Guan²,

Zhong³

2020

Engineering

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Coronavirus disease 2019 (COVID-19)—the third in a series of coronavirus infections—has caused a global public health event in the 21st century, resulting in substantial global morbidity and mortality. Building on its legacy of managing severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), China has played a key role in the scientific community by revealing the viral transmission routes and clinical characteristics of COVID-19 and developing novel therapeutic interventions and vaccines. Despite these rapid scientific and technological advances, uncertainties remain in tracing the original sources of infection, determining the routes of transmission and pathogenesis, and addressing the lack of targeted clinical management of COVID-19. Here, we summarize the major COVID-19 research advances in China in order to provide useful information for global pandemic control.

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“…Clinical and animal studies have shown that H 2 therapy reduces circulating levels of oxidative stress markers and proinflammatory cytokines in shock from a wide range of etiologies [11,24]. H 2 can be supplied from a high-pressure gas cylinder [11,12,[15][16][17], generated from a hydrogen-absorbing alloy [25,26] or hydride, or produced by electrolysis of water [7]. In recent years, on-site H 2 gas generators, which generate highpurity H 2 by electrolysis of water, have begun to be introduced in hospitals, clinics, beauty salons, and fitness clubs because of their ease of handling.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the results of a clinical study on the therapeutic effect of H 2 inhalation in COVID-19 pneumonia were reported from China [7]. In this study, the researchers used an H 2 gas generator as the source of H 2 and administered a mixture of H 2 and oxygen (O 2 ) gas (66% H 2 ; 33% O 2 ), obtained by electrolysis of water, by a nasal cannula.…”

Section: Introductionmentioning

confidence: 99%

Low-Flow Nasal Cannula Hydrogen Therapy

et al. 2020

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Background: Molecular hydrogen (H 2) is a biologically active gas that is widely used in the healthcare sector. In recent years, on-site H 2 gas generators, which produce high-purity H 2 by water electrolysis, have begun to be introduced in hospitals, clinics, beauty salons, and fitness clubs because of their ease of use. In general, these generators produce H 2 at a low-flow rate, so physicians are concerned that an effective blood concentration of H 2 may not be ensured when the gas is delivered through a nasal cannula. Therefore, this study aimed to evaluate blood concentrations of H 2 delivered from an H 2 gas generator via a nasal cannula. Methods: We administered 100% H 2 , produced by an H 2 gas generator, at a low-flow rate of 250 mL/min via a nasal cannula to three spontaneously breathing micro miniature pigs. An oxygen mask was placed over the nasal cannula to administer oxygen while minimizing H 2 leakage, and a catheter was inserted into the carotid artery to monitor the arterial blood H 2 concentration. Results: During the first hour of H 2 inhalation, the mean (standard error (SE)) H 2 concentrations and saturations in the arterial blood of the three pigs were 1,560 (413) nL/mL and 8.85% (2.34%); 1,190 (102) nL/mL and 6.74% (0.58%); and 1,740 (181) nL/mL and 9.88% (1.03%), respectively. These values are comparable to the concentration one would expect if 100% of the H 2 released from the H 2 gas generator is taken up by the body. Conclusions: Inhalation of 100% H 2 produced by an H 2 gas generator, even at low-flow rates, can increase blood H 2 concentrations to levels that previous non-clinical and clinical studies demonstrated to be therapeutically effective. The combination of a nasal cannula and an oxygen mask is a convenient way to reduce H 2 leakage while maintaining oxygenation.

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Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial

Cited by 83 publications

References 5 publications

Hydrogen: A Potential New Adjuvant Therapy for COVID-19 Patients

Hydrogen: A Potential New Adjuvant Therapy for COVID-19 Patients

Strategies and Advances in Combating COVID-19 in China

Low-Flow Nasal Cannula Hydrogen Therapy

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