Hydrogen-Ion Concentration of Gastric Contents of Infants

Babbott, Frank L.; Johnston, Joseph A.; Haskins, Charles H.; Shohl, Alfred T.

doi:10.1001/archpedi.1923.04120170086009

Cited by 13 publications

(4 citation statements)

References 3 publications

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“…Muller (1928) and Tomotake (1930) avoided the above difficulties by using either barley water or a solution of wheat flour and sugar, which have a feebler buffer action than milk. The latter author was thus able to demonstrate an increase in the total acidity and a fall in the pH of the gastric contents with advancing years, as has been stated by Babbott (1923) and five other authors quoted by him. Their conclusions, however, did not apply to infants under a year old.…”

supporting

confidence: 67%

mentioning

confidence: 99%

“…Their conclusions, however, did not apply to infants under a year old. Babbott (1923) examined the gastric contents of thirty-nine infants one hour after they had taken a feed of dried skimmed milk with these results 2) and a much slower increase from the end of that period until the fourth year of life when the values almost reached adult standards, i.e. 53 c.c.…”

mentioning

confidence: 99%

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Gastric acidity during the first year of life

Miller¹

1942

Archives of Disease in Childhood

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Prior to Cutter's investigations in 1938, the general belief was that there was little or no increase in gastric acidity during the first year of life. Hahn (1914) adopted this view after testing ninety-one specimens taken from thirtyseven infants before and after a milk feed. Hess (1913) and Griswold (1925) (1928) and Tomotake (1930) avoided the above difficulties by using either barley water or a solution of wheat flour and sugar, which have a feebler buffer action than milk. The latter author was thus able to demonstrate an increase in the total acidity and a fall in the pH of the gastric contents with advancing years, as has been stated by Babbott (1923) and five other authors quoted by him. Their conclusions, however, did not apply to infants under a year old. Babbott (1923) examined the gastric contents of thirty-nine infants one hour after they had taken a feed of dried skimmed milk with these results

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supporting

confidence: 67%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Gastric acidity during the first year of life

Miller¹

1942

Archives of Disease in Childhood

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“…The milk clots immediately, and the pH decreases22. This projected fast pH decrease is thought to stop above a pH of around 42324. To simulate these projected conditions, we started the profile at pH = 7.0, titrated within 2 min to a pH of 6.0, then within 5 min to a pH of 5.0, and subsequently within 7 min to a pH of 4.0.…”

Section: Resultsmentioning

confidence: 99%

Helicobacter pylori colonization critically depends on postprandial gastric conditions

Bücker

Azevedo-Vethacke

Groll

et al. 2012

Sci Rep

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The risk of Helicobacter pylori infection is highest in childhood, but the colonization process of the stomach mucosa is poorly understood. We used anesthetized Mongolian gerbils to study the initial stages of H. pylori colonization. Prandial and postprandial gastric conditions characteristic of humans of different ages were simulated. The fraction of bacteria that reached the deep mucus layer varied strongly with the modelled postprandial conditions. Colonization success was weak with fast gastric reacidification typical of adults. The efficiency of deep mucus entry was also low with a slow pH decrease as seen in pH profiles simulating the situation in babies. Initial colonization was most efficient under conditions simulating the postprandial reacidification and pepsin activation profiles in young children. In conclusion, initial H. pylori colonization depends on age-related gastric physiology, providing evidence from an in vivo infection model that suggests an explanation why the bacterium is predominantly acquired in early childhood.

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Progress in Pediatrics. Review of the Literature for 1923 on Infant Feeding

Moffett¹

1924

Arch Pediatr Adolesc Med

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Kuttner and Ratner 1 have undertaken to investigate the work of Theobald Smith to determine the essential nature of colostrum feeding in calves. These investigators were interested in its bearing on infant feeding. Smith showed that colostrum is not alone the chief means for transferring antibodies to the new-born calf. Colostrum also seems to have the important function of protecting the new-born animal against a general invasion by organisms of the bacillus coli group. With this in

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Hydrogen-Ion Concentration of Gastric Contents of Infants

Cited by 13 publications

References 3 publications

Gastric acidity during the first year of life

Gastric acidity during the first year of life

Helicobacter pylori colonization critically depends on postprandial gastric conditions

Progress in Pediatrics. Review of the Literature for 1923 on Infant Feeding

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