Hydrogen gas is ineffective in moderate and severe neonatal hypoxia–ischemia rat models

Matchett, Gerald; Fathali, Nancy; Hasegawa, Yu; Jadhav, Vikram; Ostrowski, Robert P.; Martin, Robert; Dorotta, Ihab; Sun, Xuejun; Zhang, Junyi

doi:10.1016/j.brainres.2008.12.066

Cited by 49 publications

(39 citation statements)

References 26 publications

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“…However, there still is a significant difference between the sham and DHCA ? H 2 group, which is similar to the results reported by Matchett et al [49] and Cai et al [13], those reports showed that brain injury induced by DHCA exceeds the therapeutic potential of short-term administration of HRS or the treatment is time-dependent on the duration of the administration of HRS. As such, further studies are still needed for clarification.…”

Section: Resultssupporting

confidence: 75%

Hydrogen-Rich Saline is Cerebroprotective in a Rat Model of Deep Hypothermic Circulatory Arrest

et al. 2011

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Deep hypothermic circulatory arrest (DHCA) has been widely used in the operations involving the aortic arch and brain aneurysm since 1950s; but prolonged DHCA contributes significantly to neurological deficit which remains a major cause of postoperative morbidity and mortality. It has been reported that hydrogen exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical. In this study, DHCA treated rats developed a significant oxidative stress, inflammatory reaction and apoptosis. The administration of HRS resulted in a significant decrease in the brain injury, together with lower production of IL-1β, TNF-α, 8-OHdG and MDA as well as decreased activity of NOS while increased activity of SOD. The apoptotic index as well as the expressions of caspase-3 in brain tissue was significantly decreased after treatment. HRS administration significantly attenuated the severity of DHCA induced brain injury by mechanisms involving amelioration of oxidative stress, down-regulation of inflammatory factors and reduction of apoptosis.

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Section: Resultssupporting

confidence: 75%

Hydrogen-Rich Saline is Cerebroprotective in a Rat Model of Deep Hypothermic Circulatory Arrest

et al. 2011

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“…During AP, oxygen free radicals play an important role in triggering subsequential lesions in the pancreas, which were produced in damaged acinar cells as well as activated neutrophils and macrophages [8, 9]. Hydrogen molecules act as a new kind of selective antioxidant, which can significantly reduce oxidative damage to the brain, liver, heart, small intestine, and so forth, caused by ischemia reperfusion, and can effectively suppress the inflammatory damage caused by colonitis and drug-induced hepatitis [10–15]. However, the effect of hydrogen-rich saline in SAP is still not fully clarified.…”

Section: Introductionmentioning

confidence: 99%

Effects of Hydrogen-Rich Saline on Taurocholate-Induced Acute Pancreatitis in Rat

Zhang

Huang

Chen

2013

Evidence-Based Complementary and Alternative Medicine

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Oxidative stress plays an important role in the pathogenesis of acute pancreatitis (AP). As an ideal exterminator of poisonous free radicals, hydrogen can clearly reduce the degree of oxidative damage caused by severe acute pancreatitis (SAP) and lessen the presence of inflammatory cytokines. The aim of this study was to investigate the effects and mechanism of hydrogen-rich saline on SAP in rats. Serum TNF-α, IL-6, and IL-18 and histopathological score in the pancreas were reduced after hydrogen-rich saline treatment. Malondialdehyde (MDA) and myeloperoxidase (MPO) contents were obviously reduced, while superoxide dismutase (SOD) and glutathione (GSH) contents were increased after hydrogen-rich saline treatment. The expression of mRNA of tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1) in the pancreas was reduced in hydrogen-rich saline treated group. In conclusion, intravenous hydrogen-rich saline injections could attenuate the severity of AP, probably via inhibiting the oxidative stress and reducing the presence of inflammatory mediators.

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“…21 Previous investigations have demonstrated that inhalation of hydrogen gas could decrease infarct cerebral volume, limit the extent of myocardial infarction, suppress hepatic injury, and alleviate damage caused by generalized inflammation or poly-microbial sepsis and improved survival rate. 12,20,[22][23][24] Therefore, hydrogen gas has exactly and widely protective effects on the injuries in different tissues or organs.…”

Section: Discussionmentioning

confidence: 99%

Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress

Zhao

et al. 2012

Neurological Research

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Hydrogen gas is ineffective in moderate and severe neonatal hypoxia–ischemia rat models

Cited by 49 publications

References 26 publications

Hydrogen-Rich Saline is Cerebroprotective in a Rat Model of Deep Hypothermic Circulatory Arrest

Hydrogen-Rich Saline is Cerebroprotective in a Rat Model of Deep Hypothermic Circulatory Arrest

Effects of Hydrogen-Rich Saline on Taurocholate-Induced Acute Pancreatitis in Rat

Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress

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