Hydrogen Evolution and Absorption Phenomena in the Plasma Membrane of Vigna radiata and Capsicum annuum

Zhang, Xin; Xie, Fei; Zhang, Zhao; Adzavon, Yao Mawulikplimi; Su, Zehua; Zhao, Qinghui; LeBaron, Tyler W.; Li, Qinjian; Lyu, Baobei; Liu, Guangyang; Liu, Mengyu; Zhao, Pengxiang; Ma, Xuemei

doi:10.1007/s00344-021-10544-7

Cited by 5 publications

(5 citation statements)

References 38 publications

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“…In our study, the inhaled hydrogen gas may probably be oxidized to water, providing an endogenous supply of H 2 O, which might explain the decrease in the water intake of rats. Moreover, in our previous studies we have provided preliminary evidence that eukaryocytes have the ability of hydrogen metabolism, which may affect its metabolic activities 49 , 50 . It is, therefore, possible to hypothesize that HI may exert its biologic role through modulation of metabolic function of mitochondria, although this needs to be further investigated.…”

Section: Discussionmentioning

confidence: 95%

Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status

Xie

Jiang

et al. 2022

Sci Rep

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The potential for preventive and therapeutic applications of H2 have now been confirmed in various disease. However, the effects of H2 on health status have not been fully elucidated. Our previous study reported changes in the body weight and 13 serum biochemical parameters during the six-month hydrogen intervention. To obtain a more comprehensive understanding of the effects of long-term hydrogen consumption, the plasma metabolome and gut microbiota were investigated in this study. Compared with the control group, 14 and 10 differential metabolites (DMs) were identified in hydrogen-rich water (HRW) and hydrogen inhalation (HI) group, respectively. Pathway enrichment analysis showed that HRW intake mainly affected starch and sucrose metabolism, and DMs in HI group were mainly enriched in arginine biosynthesis. 16S rRNA gene sequencing showed that HRW intake induced significant changes in the structure of gut microbiota, while no marked bacterial community differences was observed in HI group. HRW intake mainly induced significant increase in the abundance of Lactobacillus, Ruminococcus, Clostridium XI, and decrease in Bacteroides. HI mainly induced decreased abundances of Blautia and Paraprevotella. The metabolic function was determined by metabolic cage analysis and showed that HI decreased the voluntary intake and excretions of rats, while HRW intake did not. The results of this study provide basic data for further research on hydrogen medicine. Determination of the effects of hydrogen intervention on microbiota profiles could also shed light on identification of mechanism underlying the biological effects of molecular hydrogen.

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Section: Discussionmentioning

confidence: 95%

Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status

Xie

Jiang

et al. 2022

Sci Rep

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“…Higher organisms may have hydrogen metabolism abilities based on hydrogenase, especially for the mitochondrial-related hydrogen metabolism [ 97 , 98 ]. The cell membrane may have the enzyme activity of hydrogen metabolism, and ion channels are also possibly regulated by H 2 [ 99 , 100 ]. Recent study also put forward that, Fe-porphyrin is a H 2 -targeted molecule, acting as a biosensor and catalyst for H 2 [ 101 , 102 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition

et al. 2023

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Background Despite progress in developing wound care strategies, there is currently no treatment that promotes the self-tissue repair capabilities. H2 has been shown to effectively protect cells and tissues from oxidative and inflammatory damage. While comprehensive effects and how H2 functions in wound healing remains unknown, especially for the link between H2 and extracellular matrix (ECM) deposition and epidermal stem cells (EpSCs) activation. Methods Here, we established a cutaneous aseptic wound model and applied a high concentration of H2 (66% H2) in a treatment chamber. Molecular mechanisms and the effects of healing were evaluated by gene functional enrichment analysis, digital spatial profiler analysis, blood perfusion/oxygen detection assay, in vitro tube formation assay, enzyme-linked immunosorbent assay, immunofluorescent staining, non-targeted metabonomic analysis, flow cytometry, transmission electron microscope, and live-cell imaging. Results We revealed that a high concentration of H2 (66% H2) greatly increased the healing rate (3 times higher than the control group) on day 11 post-wounding. The effect was not dependent on O2 or anti-reactive oxygen species functions. Histological and cellular experiments proved the fast re-epithelialization in the H2 group. ECM components early (3 days post-wounding) deposition were found in the H2 group of the proximal wound, especially for the dermal col-I, epidermal col-III, and dermis-epidermis-junction col-XVII. H2 accelerated early autologous EpSCs proliferation (1–2 days in advance) and then differentiation into myoepithelial cells. These epidermal myoepithelial cells could further contribute to ECM deposition. Other beneficial outcomes include sustained moist healing, greater vascularization, less T-helper-1 and T-helper-17 cell-related systemic inflammation, and better tissue remodelling. Conclusion We have discovered a novel pattern of wound healing induced by molecular hydrogen treatment. This is the first time to reveal the direct link between H2 and ECM deposition and EpSCs activation. These H2-induced multiple advantages in healing may be related to the enhancement of cell viability in various cells and the maintenance of mitochondrial functions at a basic level in the biological processes of life.

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“…The total concentrations of gas H 2 formed in this experiment were measured by headspace gas chromatography (GC) . During the whole experiment, the system was sealed.…”

Section: Methodsmentioning

confidence: 99%

“…The total concentrations of gas H 2 formed in this experiment were measured by headspace gas chromatography (GC). 34 During the whole experiment, the system was sealed. Aqueous solutions with nZVI concentrations of 20, 30, 50, 100, 150, and 200 mg/L were prepared, placed in serum bottles, and sealed with rubber stoppers, respectively.…”

Section: Determination Of Total H 2 Contentmentioning

confidence: 99%

Hydrogen Nanobubbles Generated In Situ from Nanoscale Zerovalent Iron with Water to Further Enhance Selenite Sequestration

Huang,

Qi,

Zhou

et al. 2024

Environ. Sci. Technol.

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Gas nanobubbles used for water treatment and recovery give rise to great concern for their unique advantages of less byproducts, higher efficiency, and environmental friendliness. Nanoscale zerovalent iron (nZVI), which has also been widely explored in the field of environmental remediation, can generate gas hydrogen by direct reaction with water. Whether nanoscale hydrogen bubbles can be produced to enhance the pollution removal of the nZVI system is one significant concern involved. Herein, we report direct observations of in situ generation of hydrogen nanobubbles (HNBs) from nZVI in water. More importantly, the formed HNBs can enhance indeed the reduction of Se(IV) beyond the chemical reduction ascribed to Fe(0), especially in the anaerobic environment. The possible mechanism is that HNBs enhance the reducibility of the system and promote electron transport in the solution. This study demonstrates a unique function of HNBs combined with nZVI for the pollutant removal and a new approach for in situ HNB generation for potential applications in the fields of in situ remediation agriculture, biotechnology, medical treatment, health, etc.

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Hydrogen Evolution and Absorption Phenomena in the Plasma Membrane of Vigna radiata and Capsicum annuum

Cited by 5 publications

References 38 publications

Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status

Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status

Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition

Hydrogen Nanobubbles Generated In Situ from Nanoscale Zerovalent Iron with Water to Further Enhance Selenite Sequestration

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