Hydrogen Bonding-Driven Self-Coacervation of Nonionic Homopolymers for Stimuli-Triggered Therapeutic Release
Pampa Chowdhury,
Biswajit Saha,
Kamal Bauri
et al.
Abstract:Inspired by the unique functionalities of biomolecular membraneless organelles (MLOs) formed via liquid−liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) and nucleic acids, a great deal of effort has been devoted to devising phase-separated artificial subcellular dynamic compartments. These endeavors aim to unravel the molecular mechanism underlying the formation and intracellular delivery of susceptible macromolecular therapeutics. We report herein pyroglutamic acid (PGA)-based well-d… Show more
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