Hydrogen-bonded supramolecular polymer micelles with pH/photothermal-responsive carmofur release and combined chemo-photothermal therapy

Wu, Yanggui; Wang, Huiying; Liu, Qianqian; Lortie, Frédéric; Bernard, Julien; Binder, Wolfgang H.; Chen, Senbin; Zhu, Jintao

doi:10.1039/d1py01634b

Cited by 10 publications

(26 citation statements)

References 24 publications

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“…Currently, the fabrication methods of H-bonded complexes preparation are mostly involving nanoprecipitation [39,[70][71][72][73] and ultrasonic emulsification. [74][75][76] In addition, the development of efficient antibacterial and anti-inflammatory materials with novel mechanism of action is of great interest in view of research and clinical demand. Hbonded nanomedicine with integrated multifunctions, especially fast thermally reversible formation-dissociation processes, [77][78][79] also holds great promising potential in other diseases such as inflammatory diseases.…”

Section: Principles Of Assembly In H-bonded Nanomedicinementioning

confidence: 99%

“…Currently, the fabrication methods of H‐bonded complexes preparation are mostly involving nanoprecipitation [ 39,70–73 ] and ultrasonic emulsification. [ 74–76 ]…”

Section: Introductionmentioning

confidence: 99%

“…Very recently, we used an amphiphilic ABA triblock copolymer POEGEA‐ b ‐P(DAPA‐ co ‐TFEA)‐ b ‐POEGEA, with hydrophilic and biocompatible POEGEA block (poly(oligo (ethylene glycol) ethyl acrylate)) as exterior corona, and hydrophobic P(DAPA‐ co ‐TFEA) block (poly(diaminopyridine acrylamide‐ co ‐2,2,2‐trifluoroethyl acrylate)), which displays multiple H‐bonding 2,6‐diaminopyridine (DAP) moiety, as interior core of a delivery system ( Figure ). [ 76,108 ] The presence of the DAP moiety within the hydrophobic core enhances the loading content of carmofur (1‐hexylcarbamoyl‐5‐fluorouracil, HCFU, an approved hydrophobic antitumor agent) thanks to the establishment of selective DAP/HCFU triple H‐bonding interactions. Concomitant incorporation of IR780, a photothermal agent, promoted the development of a combined chemo‐photothermal therapy (CT/PTT) drug delivery platform, where HCFU is released in a controlled manner, owing to the dissociation of DAP/HCFU H‐bonding interactions after a temperature‐induced stimulus.…”

Section: Introductionmentioning

confidence: 99%

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Hydrogen‐Bonds‐Mediated Nanomedicine: Design, Synthesis, and Applications

Chen

Lortie

et al. 2022

Macromol. Rapid Commun.

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Among the various challenges in medicine, diagnosis, complete cure, and healing of cancers remain difficult given the heterogeneity and complexity of such a disease. Differing from conventional platforms with often unsatisfactory theranostic capabilities, the contribution of supramolecular interactions, such as hydrogen-bonds (H-bonds), to cancer nanotheranostics opens new perspectives for the design of biomedical materials, exhibiting remarkable properties and easier processability. Thanks to their dynamic characteristics, a feature generally observed for noncovalent interactions, H-bonding (macro)molecules can be used as supramolecular motifs for yielding drug-and diagnostic carriers that possess attractive features, arising from the combination of assembled nanoplatforms and the responsiveness of H-bonds. Thus, H-bonded nanomedicine provides a rich toolbox that is useful to fulfill biomedical needs with unique advantages in early-stage diagnosis and therapy, demonstrating the promising potential in clinical translations and applications. Here the design and synthetic routes toward H-bonded nanomedicines, focus on the growing understanding of the structure-function relationship for efficient cancer treatment are summarized. A guidance for designing new H-bonded intelligent theranostic agents is proposed, to inspire more successful explorations of cancer nanotheranostics and finally to promote potential clinical translations.

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Section: Principles Of Assembly In H-bonded Nanomedicinementioning

confidence: 99%

“…Currently, the fabrication methods of H‐bonded complexes preparation are mostly involving nanoprecipitation [ 39,70–73 ] and ultrasonic emulsification. [ 74–76 ]…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hydrogen‐Bonds‐Mediated Nanomedicine: Design, Synthesis, and Applications

Chen

Lortie

et al. 2022

Macromol. Rapid Commun.

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“…Then, the flask was placed into the preheated oil bath at 120 °C for 12 h. The mixture was then added into an excess of MeOH to remove the unpolymerized monomers. Finally, the product was dried under vacuum and characterized by SEC (Figure S1) and 1 H and 19 F NMR (Figure S2). S1) were calculated according to following equations, respectively…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…17 We recently also employed an amphiphilic triblock copolymer as a drug carrier, which exhibits multiple H-bonding moieties (e.g., 2,6-diaminopyridine, DAP) within the inner core. 18,19 DAP moieties can enhance the loading capability of 1-hexylcarbamoyl-5-fluorouracil (HCFU, a FDA-approved chemotherapeutic agent) through the specific H-bonding association between DAP and HCFU. Concomitant encapsulation of IR780, a photothermal agent, leads to the achievement of designed synergistic CT/PTT, in which HCFU can be released in a controlled manner because of H-bond dissociation between DAP and HCFU under pH/temperature stimulus.…”

Section: ■ Introductionmentioning

confidence: 99%

Hydrogen Bond-Mediated Supramolecular Polymeric Nanomedicine with pH/Light-Responsive Methotrexate Release and Synergistic Chemo-/Photothermal Therapy

Chen

Zhu

2022

Biomacromolecules

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Complete cancer cure and healing are still difficult, owing to its complexity and heterogeneity. Integration of supramolecular forces, for example, hydrogen bonds (H-bonds), to anti-cancer nanomedicine affords new scaffolds for biomedical material decoration, featuring the advantages of dynamic property and easier processability. Here, we target the construction of Hbond-mediated supramolecular polymer micelles, loaded with a chemotherapeutic drug along with a photothermal agent for synergistic chemo-/photothermal therapies (CT/PTT). To do so, we design and synthesize an amphiphilic ABA-type triblock copolymer, bearing H-bonding moiety (barbiturate, Ba) within the middle hydrophobic B block. The presence of pendant Ba moieties within the hydrophobic core promotes the loading capability of methotrexate (MTX) and transportation stability, benefitting from the formation of specific Ba/MTX H-bonding interactions. IR780, a photothermal agent, concomitantly encapsulated via hydrophobic interactions, facilitates the development of a synergistic CT/PTT modalities, where MTX can be released on demand owing to the dissociation of Ba/MTX H-bonding interactions induced by elevated temperature. Such H-bonding nanomedicine possesses enhanced drug loading capacity and transport performance and can also trigger stimuli-responsive drug release in the tumor zone. We believe that H-bonded nanomedicines provide a fine toolbox that is conducive to attaining biomedical requirements with remarkable values in theranostics that are highly promising in clinical applications.

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Polymer materials for constructing therapeutical nanoparticles in photothermal therapy

Li,

Liu,

Zhang

2023

Journal of Polymer Science

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Photothermal therapy (PTT) ablates tumors by thermal effects of photothermal agents (PTAs), and attracts wide attention due to the non‐invasive characteristic. The ideal PTAs are expected to have high photothermal conversion effect under NIR irradiation, as well as targeting abilities and good biocompatibility satisfying the need of application in vivo. Nanoparticles (NPs) are commonly used as anti‐tumor materials, and plenty of researches on therapeutical NPs for PTT treatment have been developed. Among various building blocks for photothermal NPs, polymer materials for biomedical applications have great advantages due to their negligible toxicity, flexibility for functional modification, and ability to integrate multiple therapeutic strategies. This review focuses on the polymer materials utilized in photothermal NP designing, including their application as excellent carriers and powerful PTAs with great PTT effects. Furthermore, the synergy therapy based on polymeric nanoplatform for enhancing PTT therapeutic efficiency will be introduced.

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Hydrogen-bonded supramolecular polymer micelles with pH/photothermal-responsive carmofur release and combined chemo-photothermal therapy

Abstract: Integrating biomedical applications (e.g., drug delivery) into supramolecular chemistry is a promising strategy. This work targets the construction of hydrogen-bonded (H-bonded) supramolecular polymeric micelles loaded with chemotherapy drugs (carmofur) and...

Cited by 10 publications

References 24 publications

Hydrogen‐Bonds‐Mediated Nanomedicine: Design, Synthesis, and Applications

Hydrogen‐Bonds‐Mediated Nanomedicine: Design, Synthesis, and Applications

Hydrogen Bond-Mediated Supramolecular Polymeric Nanomedicine with pH/Light-Responsive Methotrexate Release and Synergistic Chemo-/Photothermal Therapy

Polymer materials for constructing therapeutical nanoparticles in photothermal therapy

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