Hydrogen-Bonded Organic Frameworks Chelated Manganese for Precise Magnetic Resonance Imaging Diagnosis of Cancers

Ouyang, Sixue; Chen, Chuyao; Lin, Peiru; Wu, Wanjia; Chen, Guanjun; Li, Pengfei; Sun, Mingyan; Chen, Huiting; Zheng, Zhiyuan; You, Yuanyuan; Lv, Sike; Zhao, Peng; Lin, Bingquan; Tao, Jia

doi:10.1021/acs.nanolett.3c02466

Cited by 6 publications

(2 citation statements)

References 47 publications

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“…Recently, metal–organic framework (MOF) is an emerging porous coordination framework material formed by the coordination of metal ions or metal clusters with organic ligands. − Compared with the traditional drug delivery system, MOF has broad application prospects in drug delivery due to its advantages of high porosity, large specific surface area and easy modification. − Interestingly, the coordination between bivalent metal ions and organic ligands is reversible, which can be broken under low pH condition to achieve intelligent drug release. − As a typical MOF, zeolite imidazole framework-8 (ZIF-8) is formed by the coordination of Zn 2+ with the N atom on the 2-methylimidazole (2-MIM). − Zn 2+ is essential for human body and 2-MIM is involved in histidine metabolism . These advantages endow ZIF-8 with versatile biomedical applications as an ideal drug carrier.…”

Section: Introductionmentioning

confidence: 99%

Autocatalytic Artesunate Coordinated ZIF-8 Nanoplatforms with Metal-Polyphenol Network Coating for Targeted Tumor Chemodynamic Therapy

Zhang,

Yu,

Zhuang

et al. 2024

ACS Appl. Nano Mater.

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Artesunate (Art) with a unique peroxy-bridging bond can react with a ferrous ion and produce excess carbon-centered radicals, which cause irreversible damage to tumor cells. However, the antitumor effect of artesunate still faces challenges due to its poor water solubility and insufficient amount of ferrous ions in tumor cells. Herein, we constructed artesunate coordinated zeolite imidazole framework nanoplatforms (Art/ZIF NPs) coated with ferric ion-rutin network (Ru–Fe@Art/ZIF NPs) for synergy therapy. In virtue of zinc-ion-mediated coordination, Art was efficiently loaded into ZIF-8 NPs (loading capacity and rate are 29.58 and 30.73%) and responsively released under an acidic environment. Meanwhile, the introduction of rutin (a type of plant flavonoid) not only enabled tumor targeting via GLUT receptors but also reduced Fe3+ to Fe2+ under acidic conditions. Subsequently, these ferrous ions loading with Art enhance the tumor killing effect via radical-dependent cell cycle arrest. This “core–shell” autocatalytic nanoplatform provides a novel strategy for developing Art-based chemodynamic therapy.

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Section: Introductionmentioning

confidence: 99%

Autocatalytic Artesunate Coordinated ZIF-8 Nanoplatforms with Metal-Polyphenol Network Coating for Targeted Tumor Chemodynamic Therapy

Zhang,

Yu,

Zhuang

et al. 2024

ACS Appl. Nano Mater.

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“…In recent years, research has shifted towards Metal-Organic Frameworks (MOFs) and their derivatives (raw MOFs and composites) for fabricating electrochemical glucose sensors due to their attractive properties such as porous structure, large surface area, metallic active sites, and excellent electro-catalytic activity. 8,9 MOFs are a class of unique porous materials of composed of metal ions or clusters surrounded by multiple organic ligands that have attracted their consideration for application as active electrode materials for non-enzymatic glucose sensors. [10][11][12] Recently, Ni-MOF was prepared by using 2,3,6,7,10,11-hexahydroxytriphenylene and nickel precursor and fabricated as a non-enzymatic glucose sensor.…”

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confidence: 99%

Highly Efficient Non-Enzymatic Electrochemical Glucose Biosensor Based on Copper Metal Organic Framework Coated on Graphite Sheet

Kumari,

Prajapati,

Ravi Kant

2024

ECS J. Solid State Sci. Technol.

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Detection of glucose is highly informative, creating a constant demand for fabricating high-precision glucose biosensors. Metal–organic frameworks, a family of porous materials renowned for their tunability, can be an excellent choice for developing such sensors. We have developed a highly-sensitive, non-enzymatic sensor for electrochemical detection of glucose fabricated using Copper Metal–Organic Framework (Cu MOF), synthesized by a simple, room-temperature stirring method using Benzene-1,3,5-tricarboxylic acid (BTC) as ligand and Copper nitrate trihydrate as precursor. The synthesized nanostructure was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray analytical techniques. Powder X-ray diffraction study and thermogravimetric analysis were also done. Further, Brunnauer-Emmett-Teller analysis revealed the porous nature of Cu MOF. The materials exhibited strong electro-catalytic activity for glucose oxidation as revealed from cyclic voltammetry and chronoamperometric studies done under alkaline pH conditions. The Cu MOF deposited on a conducting graphite sheet electrode displayed a significantly low detection limit of 0.019 mM through a broad detection range (1–15 mM) and a strong sensitivity of 229.4 μAmM-1 cm2. Overall, the Cu MOF/GS exhibits exceptional stability, short response time (less than 1s), and good repeatability and reproducibility, making it a promising future material for non-enzymatic glucose detection.

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Boosting Ferroptosis and immunotherapy for Colorectal Cancer by Lactate‐Related Metabolic Reprogramming

Li,

He,

Xie

et al. 2024

Adv Funct Materials

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As the presence of anaerobic metabolism of glucose, solid tumors characteristically display higher levels of lactate production, which attenuate ferroptosis therapy and the subsequent anti‐tumor immune response. Herein, hyaluronic acid (HA)‐modified and lactate oxidase (LOX)‐loaded nanoscale metal organic frameworks (MOFs), termed as FCS@LOX@HA (FCSLH) is constructed, achieving tumor‐targeted metabolic combined chemo‐dynamic therapy (CDT). Notably, the high LOX‐loading capacity of MOFs is achieved by adjusting the Fe/Cu ratio. Upon internalization by cancer cells, the FCS MOFs reacted with local glutathione (GSH) to release Fe/Cu ions for CDT. Meanwhile, the LOX catalyzed endogenous lactate to pyruvate accompanied with a release of H2O2; while the latter can enhance the FCS MOFs‐mediated CDT effect. Additionally, lactate exhaustion can impair the antioxidant system by inhibiting the HIF‐1α/SLC1A1 pathway, resulting in the accumulation of lipid peroxidation, and ferroptosis occurs accompanied by immunogenic cell death. Furthermore, lactate exhaustion within tumor‐associated macrophages (TAMs) can inhibit M2 macrophage polarization by suppressing the NF‐κB/HIF‐1α pathway, thereby augmenting anti‐tumor immune response. The in vivo studies demonstrated that cooperating with PD‐L1 antibodies can achieve excellent anti‐tumor therapeutic efficacy. Taken together, FCSLH can amplify the ferroptosis‐mediated immune response through simultaneous dysfunction of cancer cells and TAMs, which provides novel insight for integrating metabolic programmed therapy and immunotherapy.

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Hydrogen-Bonded Organic Frameworks Chelated Manganese for Precise Magnetic Resonance Imaging Diagnosis of Cancers

Cited by 6 publications

References 47 publications

Autocatalytic Artesunate Coordinated ZIF-8 Nanoplatforms with Metal-Polyphenol Network Coating for Targeted Tumor Chemodynamic Therapy

Autocatalytic Artesunate Coordinated ZIF-8 Nanoplatforms with Metal-Polyphenol Network Coating for Targeted Tumor Chemodynamic Therapy

Highly Efficient Non-Enzymatic Electrochemical Glucose Biosensor Based on Copper Metal Organic Framework Coated on Graphite Sheet

Boosting Ferroptosis and immunotherapy for Colorectal Cancer by Lactate‐Related Metabolic Reprogramming

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