Hydrogen-bond interactions and their influence on conformation of retinoidal-active and -inactive aromatic anilides

Abstract

Tolterodine is a drug substance contammg (+)-N,Ndiisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylprolylamine hydrogen L(+)-tartrate CC26H37N07).The drug is used for the treatment of minary frequency, urgency and/or urge incontinence. The synthesis of tolterodin L(+)-tartrate is a well established procedure. The crystal structure of tolterodine L(+)-tartrate was determined from single crystal x-ray data at room temperature and 30 K. The structure is monoclinic with two formula units in.the unit cell and all the atoms in the general position of the space-group P2J. The unit cell dimensions at 30 K are a= 9.1759, b = 16.3965c =l2.9196A. = 93.427". In the final stage of the refinement the 3568 reflections recorded at 30 K were refined to an R-value of 4.0%.