Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial

Song, Guohua; Lin, Quanqiang; Zhao, Haoqiang; Liu, Meiyuan; Ye, Fenglong; Sun, Yu; Yu, Yang; Guo, Shoudong; Jiao, Peng; Wu, Yungang; Ding, Guoyong; Xiao, Qiang; Qin, Shucun

doi:10.1210/jc.2015-1321

Cited by 43 publications

(37 citation statements)

References 34 publications

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“…It can complement traditional therapy in rheumatoid arthritis [13], chronic hepatitis B [14], Parkinson's disease [15] and atherosclerosis [16] due to reduction of oxidative stress.…”

Section: Research Of Existing Solutions Of the Problemmentioning

confidence: 99%

Influence of redox potential of different water quality on the human blood

Matsiyevska

2017

TAPR

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“…It can complement traditional therapy in rheumatoid arthritis [13], chronic hepatitis B [14], Parkinson's disease [15] and atherosclerosis [16] due to reduction of oxidative stress.…”

Section: Research Of Existing Solutions Of the Problemmentioning

confidence: 99%

Influence of redox potential of different water quality on the human blood

Matsiyevska

2017

TAPR

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“… 34 DB Water Increased flow-mediated dilation of branchial artery, suggesting that H 2 can serve as a modulator of vasomotor function of vasculature. Song et al [ 244 ]/2015 Hyperlipidemia 68 DB Water Down-regulation of plasma levels of total cholesterol, and LDL-cholesterol, followed by increased plasma pre-β -HDL, apoM, and decreased plasma oxidized-LDL, apoB100. …”

Section: Introductionmentioning

confidence: 99%

Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -

et al. 2015

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Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. In most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. Hydrogen water is mostly given ad libitum. Hydrogen gas of less than 4 % is given by inhalation. The effects have been reported in essentially all organs covering 31 disease categories that can be subdivided into 166 disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants with a predominance of oxidative stress-mediated diseases and inflammatory diseases. Specific extinctions of hydroxyl radical and peroxynitrite were initially presented, but the radical-scavenging effect of hydrogen cannot be held solely accountable for its drastic effects. We and others have shown that the effects can be mediated by modulating activities and expressions of various molecules such as Lyn, ERK, p38, JNK, ASK1, Akt, GTP-Rac1, iNOS, Nox1, NF-κB p65, IκBα, STAT3, NFATc1, c-Fos, and ghrelin. Master regulator(s) that drive these modifications, however, remain to be elucidated and are currently being extensively investigated.

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“…It has been recently established in patients with hypercholesterolemia that the consumption of one L/day of H 2 -enriched water for a period of 10 weeks can activate the ATP-binding cassette transporter A1-dependent cholesterol efflux system. This improved the function of HDL lipoproteins in patients with hypercholesterolemia in a double-blind, placebo-controlled clinical trial (47% reduction, p < 0.05) [160].…”

Section: Hydrogen and Metabolic Diseasesmentioning

confidence: 97%

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

Nicolson¹,

Ferreira²,

Settineri³

et al. 2016

IJCM

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Here we review the literature on the effects of molecular hydrogen (H2) on normal human subjects and patients with a variety of diagnoses, such as metabolic, rheumatic, cardiovascular and neurodegenerative and other diseases, infections and physical and radiation damage as well as effects on aging and exercise. Although the effects of H2 have been studied in multiple animal models of human disease, such studies will not be reviewed in depth here. H2 can be administered as a gas, in saline implants or infusions, as topical solutions or baths or by drinking H2-enriched water. This latter method is the easiest and least costly method of administration. There are no safety issues with hydrogen; it has been used for years in gas mixtures for deep diving and in numerous clinical trials without adverse events, and there are no warnings in the literature of its toxicity or longterm exposure effects. Molecular hydrogen has proven useful and convenient as a novel antioxidant and modifier of gene expression in many conditions where oxidative stress and changes in gene expression result in cellular damage.

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Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial

Abstract: H2 activates ATP-binding cassette transporter A1-dependent efflux, enhances HDL antiatherosclerotic functions, and has beneficial lipid-lowering effects. The present findings highlight the potential role of H2 in the regression of hypercholesterolemia and atherosclerosis.

Cited by 43 publications

References 34 publications

Influence of redox potential of different water quality on the human blood

Influence of redox potential of different water quality on the human blood

Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

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