Hydrogels porosity and bacteria penetration: Where is the pore size threshold?

Imprinted Contact Lenses for Sustained Release of Polymyxin B and Related Antimicrobial Peptides

“…The small volume of water added favored drug dissolution and interaction with AAc before polymerization, and it may also increase hydrogel mesh size without leading to pores formation. 32 In summary, proportions of AAc, cross-linker, drug and water play all an important role in the polymyxin B loading performance of the hydrogels.…”

Influence of adsorbed polyelectrolytes on pore size distribution of a water-swollen biomaterial

“…Moreover, the pore size distributions of hydrogels are not usually retained after simple drying. 57 As the pore size of hydrogels is important in many of their applications, from tissue engineering 58 to wound dressing, 59 a conceptual approach for the adjustment of the pore size distribution represents an interesting idea for materials scientists working with water-swollen materials.…”

Wear effects on microscopic morphology and hyaluronan uptake in siloxane‐hydrogel contact lenses

“…Other limitations of these techniques are the lack of information on the HA distribution and penetration in the core of the lens, as well as on the morphology and structure of the HA‐loaded lenses, such as the presence of pores, the capability of the HA to fill them, the possible aggregation of HA in clusters, the size of these clusters, and the compatibility with their internalization in the polymeric network of the lens. As far as the lens structure is concerned, few studies performed by scanning electron microscopy (SEM) are reported in the literature, mainly on unworn contact lenses, but further details deserve to be investigated, such as the effects of wear and the relationships with solute uptake. Detailed investigations also require the improvement of the acquisition technique.…”