Hydrogels for RNA delivery

Zhong, Ruibo; Talebian, Sepehr; Mendes, Bárbara B.; Wallace, Gordon G.; Langer, Robert; Conde, João; Shi, Jinjun

doi:10.1038/s41563-023-01472-w

Cited by 103 publications

(55 citation statements)

References 119 publications

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“…Additionally, adding hydrogenator molecules such as tetrazole and spiropyran in RNA drug delivery carriers such as hydrogels could also introduce the hydrophobic interactions to increase the RNA loading (Figure d) . However, this hydrophobic interaction mainly depends on the hydrophobic modifier on RNA not on RNA itself …”

Section: Rna Interactions With Nanocarriersmentioning

confidence: 99%

Bioinspired Spatiotemporal Management toward RNA Therapies

Ma,

Li,

Lin

et al. 2023

ACS Nano

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Section: Rna Interactions With Nanocarriersmentioning

confidence: 99%

Bioinspired Spatiotemporal Management toward RNA Therapies

Ma,

Li,

Lin

et al. 2023

ACS Nano

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“…The gene-activated matrices enable high and sustained transgene expression and protect therapeutic genes from immune responses and degradation while locally delivering genes to target cells with reduced nonspecific effects. 68 Compared with direct growth factor delivery, gene delivery offers notable advantages, including sustained and controlled expression and reduced immunogenicity. Several excellent recent reviews discuss the benefits of hydrogel-based gene delivery.…”

Section: Protein/gene Delivery Strategies To Promote Vascular Regener...mentioning

confidence: 99%

“…Several excellent recent reviews discuss the benefits of hydrogel-based gene delivery. [68][69][70] A topical delivery system combining hyaluronic acid hydrogel with collagen mimetic peptides was developed for tethering DNA/polyethyleneimine polyplexes. 71 MMP-mediated collagen degradation facilitated polyplex internalization and modulated VEGF gene transfer kinetics in fibroblasts.…”

Section: Protein/gene Delivery Strategies To Promote Vascular Regener...mentioning

confidence: 99%

Hydrogels to Recapture Extracellular Matrix Cues That Regulate Vascularization

Song

Gerecht

2023

ATVB

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The ECM (extracellular matrix) is a 3-dimensional network that supports cellular responses and maintains structural tissue integrity in healthy and pathological conditions. The interactions between ECM and cells trigger signaling cascades that lead to phenotypic changes and structural and compositional turnover of the ECM, which in turn regulates vascular cell behavior. Hydrogel biomaterials are a powerful platform for basic and translational studies and clinical applications due to their high swelling capacity and exceptional versatility in compositions and properties. This review highlights recent development and use of engineered natural hydrogel platforms that mimic the ECM and present defined biochemical and mechanical cues for vascularization. Specifically, we focus on modulating vascular cell stimulation and cell-ECM/cell-cell interactions in the microvasculature that are influenced by the established biomimetic microenvironment.

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“…Hydrogels are three-dimensional water-swollen networks with hydrophilic nature crosslinked by various hydrophilic polymers via chemical covalent bonds, physical non-covalent bonds or a combination of both. 1–4 Meanwhile, hydrogels could be further classified as natural, synthetic or hybrid based on the source of constituting materials. 4–6 Due to their excellent biocompatibility, extracellular matrix (ECM)-like structure and immensely tunable properties (modified through physical/chemical methods) for specific applications, hydrogels are one of the most widely utilized soft biomaterials in tissue engineering (providing mechanical support and scaffold for tissue regeneration, transporting drugs/cells/cytokines/bioactive molecules, etc .).…”

Section: Introductionmentioning

confidence: 99%

“…4–6 Due to their excellent biocompatibility, extracellular matrix (ECM)-like structure and immensely tunable properties (modified through physical/chemical methods) for specific applications, hydrogels are one of the most widely utilized soft biomaterials in tissue engineering (providing mechanical support and scaffold for tissue regeneration, transporting drugs/cells/cytokines/bioactive molecules, etc .). 2,7–13 After the first appearance of the term “hydrogel” in the scientific literature in 1894, 14 great progress has been made in hydrogels and related fields, especially in the last few decades. To date, the historical development of hydrogels could be divided into three different generations.…”

Section: Introductionmentioning

confidence: 99%