Hydrogels‐Based Electronic Devices for Biosensing Applications

Liang, Quanduo; Lu, Yuehui; Zhang, Qiang

doi:10.1002/9783527832385.ch10

Cited by 3 publications

(5 citation statements)

References 135 publications

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“…200,202 The operational lifetime of a wearable biosensor, i.e., the time period which the biosensor retains its performance and sensitivity, is a critical factor that determines its practicality and usefulness. 203 Factors that influence the lifetime of wearable biosensors include the materials' stability and biocompatibility, 204 mechanical properties of the hydrogel, 205 and the complexity of the sensors and electronics. 206 The hydrogel must also be stable against degradation, swelling, and shrinking while being nontoxic.…”

Section: ■ Commercialization Aspectsmentioning

confidence: 99%

Challenges and Advances of Hydrogel-Based Wearable Electrochemical Biosensors for Real-Time Monitoring of Biofluids: From Lab to Market. A Review

Chenani,

Saeidi,

Rastkhiz

et al. 2024

Anal. Chem.

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Section: ■ Commercialization Aspectsmentioning

confidence: 99%

Challenges and Advances of Hydrogel-Based Wearable Electrochemical Biosensors for Real-Time Monitoring of Biofluids: From Lab to Market. A Review

Chenani,

Saeidi,

Rastkhiz

et al. 2024

Anal. Chem.

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“…Hydrogels with a unique structure, including a three-dimensional (3D) network of crosslinked polymers, can absorb and retain large amounts of water in their interstitial spaces whilst maintaining their structural integrity in the swollen state [ 21 ]. The hydrogel surface can also be functionalized by various functional groups to enhance their specificity toward the target analyte [ 22 ]. In addition, hydrogels can be functionalized with various biorecognition elements, including enzymes, antibodies, and nucleic acids, to specifically detect the analyte of interest [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…HWEBs offer a unique combination of mechanical and chemical stability, biocompatibility, and high swelling capacity, which is essential for detecting biological analytes in complex environments [ 22 , 24 ]. The hydrogel surface can also be functionalized by various functional groups to enhance their specificity toward the target analyte [ 22 ]. The immobilized biomolecules in HWEBs can catalyze a corresponding redox reaction, leading to a change in the current, potential, or impedance at the electrode surface [ 22 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…The hydrogel surface can also be functionalized by various functional groups to enhance their specificity toward the target analyte [ 22 ]. The immobilized biomolecules in HWEBs can catalyze a corresponding redox reaction, leading to a change in the current, potential, or impedance at the electrode surface [ 22 , 25 ]. The softness of HWEBs can release mechanical stress on the biological elements, leading to more stable and reliable biosensors [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Wearable Biosensors and Bioelectronic Devices Based on Hydrogels: Mechanical Properties and Electrochemical Behavior

Saeidi,

Chenani,

Orouji

et al. 2023

Biosensors

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Hydrogel-based wearable electrochemical biosensors (HWEBs) are emerging biomedical devices that have recently received immense interest. The exceptional properties of HWEBs include excellent biocompatibility with hydrophilic nature, high porosity, tailorable permeability, the capability of reliable and accurate detection of disease biomarkers, suitable device–human interface, facile adjustability, and stimuli responsive to the nanofiller materials. Although the biomimetic three-dimensional hydrogels can immobilize bioreceptors, such as enzymes and aptamers, without any loss in their activities. However, most HWEBs suffer from low mechanical strength and electrical conductivity. Many studies have been performed on emerging electroactive nanofillers, including biomacromolecules, carbon-based materials, and inorganic and organic nanomaterials, to tackle these issues. Non-conductive hydrogels and even conductive hydrogels may be modified by nanofillers, as well as redox species. All these modifications have led to the design and development of efficient nanocomposites as electrochemical biosensors. In this review, both conductive-based and non-conductive-based hydrogels derived from natural and synthetic polymers are systematically reviewed. The main synthesis methods and characterization techniques are addressed. The mechanical properties and electrochemical behavior of HWEBs are discussed in detail. Finally, the prospects and potential applications of HWEBs in biosensing, healthcare monitoring, and clinical diagnostics are highlighted.

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Development of Poly(vinyl alcohol) Grafted Glycidyl Methacrylate/Cellulose Nanofiber Injectable Hydrogels for Meniscus Tissue Engineering

Sinna,

Jeencham,

Mueangkhot

et al. 2023

Polymers

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This study aimed to develop poly (vinyl alcohol) grafted glycidyl methacrylate/cellulose nanofiber (PVA-g-GMA/CNF) injectable hydrogels for meniscus tissue engineering. PVA-g-GMA is an interesting polymer for preparing cross-linking injectable hydrogels with UV radiation, but it has poor mechanical properties and low cell proliferation. In this study, CNF as a reinforcing agent was selected to improve mechanical properties and cell proliferation in PVA-g-GMA injectable hydro-gels. The effect of CNF concentration on hydrogel properties was investigated. Both PVA-g-GMA and PVA-g-GMA hydrogels incorporating 0.3, 0.5, and 0.7% (w/v) CNF can be formed by UV curing at a wavelength of 365 nm, 6 mW/cm2 for 10 min. All hydrogels showed substantial microporosity with interconnected tunnels, and a pore size diameter range of 3–68 µm. In addition, all hydrogels also showed high physicochemical properties, a gel fraction of 81–82%, porosity of 83–94%, water content of 73–87%, and water swelling of 272–652%. The water content and swelling of hydrogels were increased when CNF concentration increased. It is worth noting that the reduction of porosity in the hydrogels occurred with increasing CNF concentration. With increasing CNF concentration from 0.3% to 0.7% (w/v), the compressive strength and compressive modulus of the hydrogels significantly increased from 23 kPa to 127 kPa and 27 kPa to 130 kPa, respectively. All of the hydrogels were seeded with human cartilage stem/progenitor cells (CSPCs) and cultured for 14 days. PVA-g-GMA hydrogels incorporating 0.5% and 0.7% (w/v) CNF demonstrated a higher cell proliferation rate than PVA-g-GMA and PVA-g-GMA hydrogels incorporating 0.3% (w/v) CNF, as confirmed by MTT assay. At optimum formulation, 10%PVA-g-GMA/0.7%CNF injectable hydrogel met tissue engineering requirements, which showed excellent properties and significantly promoted cell proliferation, and has a great potential for meniscus tissue engineering application.

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Hydrogels‐Based Electronic Devices for Biosensing Applications

Cited by 3 publications

References 135 publications

Challenges and Advances of Hydrogel-Based Wearable Electrochemical Biosensors for Real-Time Monitoring of Biofluids: From Lab to Market. A Review

Challenges and Advances of Hydrogel-Based Wearable Electrochemical Biosensors for Real-Time Monitoring of Biofluids: From Lab to Market. A Review

Electrochemical Wearable Biosensors and Bioelectronic Devices Based on Hydrogels: Mechanical Properties and Electrochemical Behavior

Development of Poly(vinyl alcohol) Grafted Glycidyl Methacrylate/Cellulose Nanofiber Injectable Hydrogels for Meniscus Tissue Engineering

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