Hydrogel/nanoparticles-mediated cooperative combination of antiangiogenesis and immunotherapy

Yang, Afeng; Sheng, Shupei; Bai, Yun; Xing, Guozheng; Yu, Xuya; Zhu, Dunwan; Mei, Lin; Dong, Xia; Lv, Feng

doi:10.1016/j.actbio.2022.09.060

Cited by 7 publications

(6 citation statements)

References 45 publications

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“…38,39 It can be synergistically enhance the efficacy of chemotherapy, PTT, immunotherapy, and other cancer therapies. 40–42…”

Section: Resultsmentioning

confidence: 99%

“…38,39 It can be synergistically enhance the efficacy of chemotherapy, PTT, immunotherapy, and other cancer therapies. [40][41][42] The acidic pH response can be successfully utilized in the PLGA NP system as the cellular organelles and tumor microenvironments are typically acidic. The photothermal heat at 5 h, 10 h, and 15 h time points showed moderately increased drug release from PLGA NP carriers (Fig.…”

Section: Materials Advances Papermentioning

confidence: 99%

See 1 more Smart Citation

NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice

Khan,

Newaj,

Rahman

et al. 2023

Mater. Adv.

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“…38,39 It can be synergistically enhance the efficacy of chemotherapy, PTT, immunotherapy, and other cancer therapies. 40–42…”

Section: Resultsmentioning

confidence: 99%

Section: Materials Advances Papermentioning

confidence: 99%

NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice

Khan,

Newaj,

Rahman

et al. 2023

Mater. Adv.

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“…Reprinted from Acta Biomater , 153, Yang Af, Sheng SP, Bai Y, et al Hydrogel/nanoparticles-mediated cooperative combination of antiangiogenesis and immunotherapy, 124–138, Copyright (2022), with permission from Elsevier. 106 …”

Section: Nano-delivery Systems Enhance Cancer Immunotherapy By Modula...mentioning

confidence: 99%

Cancer Immunotherapy with “Vascular-Immune” Crosstalk as Entry Point: Associated Mechanisms, Therapeutic Drugs and Nano-Delivery Systems

Jiang,

Fang,

Hong

et al. 2024

IJN

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Tumor vessels characterized by abnormal functions and structures hinder the infiltration and immune antigen presentation of immune cells by inducing the formation of an immunosuppressive microenvironment (“cold” environment). Vascular-targeted therapy has been proven to enhance immune stimulation and the effectiveness of immunotherapy by modulating the “cold” microenvironment, such as hypoxia and an acidic microenvironment. Notably, a therapeutic strategy based on “vascular-immune” crosstalk can achieve dual regulation of tumor vessels and the immune system by reprogramming the tumor microenvironment (TME), thus forming a positive feedback loop between tumor vessels and the immune microenvironment. From this perspective, we discuss the factors of tumor angiogenesis and “cold” TME formation. Building on this foundation, some vascular-targeted therapeutic drugs will be elaborated upon in detail to achieve dual regulation of tumor vessels and immunity. More importantly, we focus on cutting-edge nanotechnology in view of “vascular-immune” crosstalk and discuss the rational fabrication of tailor-made nanosystems for efficiently enhancing immunotherapy.

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“…Black phosphorus-based PTT was capable of directly killing tumor cells, releasing tumor-related antigens, and stimulating immune response, thereby alleviating TMW immunosuppression [ 283 ]. Yang et al adopted a hydrogel/nanomaterial composite system to construct a dual slow-release drug system, which regulated the TME by controlling the release of Apatinib, CD47 antibody (aCD47), and CpG, strengthened the synergistic impact on the primary tumor, and prevented tumor metastasis [ 284 ]. The development of scientific and effective treatment strategies for TME is conducive to relieving intratumor immunosuppression, limiting tumor immune escape, and enhancing the efficacy of tumor immunotherapy.…”

Section: Biomaterials Used In Tumor Immunotherapymentioning

confidence: 99%

Emerging biomaterials for tumor immunotherapy

et al. 2023

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Background The immune system interacts with cancer cells in various intricate ways that can protect the individual from overproliferation of cancer cells; however, these interactions can also lead to malignancy. There has been a dramatic increase in the application of cancer immunotherapy in the last decade. However, low immunogenicity, poor specificity, weak presentation efficiency, and off-target side effects still limit its widespread application. Fortunately, advanced biomaterials effectively contribute immunotherapy and play an important role in cancer treatment, making it a research hotspot in the biomedical field. Main body This review discusses immunotherapies and the development of related biomaterials for application in the field. The review first summarizes the various types of tumor immunotherapy applicable in clinical practice as well as their underlying mechanisms. Further, it focuses on the types of biomaterials applied in immunotherapy and related research on metal nanomaterials, silicon nanoparticles, carbon nanotubes, polymer nanoparticles, and cell membrane nanocarriers. Moreover, we introduce the preparation and processing technologies of these biomaterials (liposomes, microspheres, microneedles, and hydrogels) and summarize their mechanisms when applied to tumor immunotherapy. Finally, we discuss future advancements and shortcomings related to the application of biomaterials in tumor immunotherapy. Conclusion Research on biomaterial-based tumor immunotherapy is booming; however, several challenges remain to be overcome to transition from experimental research to clinical application. Biomaterials have been optimized continuously and nanotechnology has achieved continuous progression, ensuring the development of more efficient biomaterials, thereby providing a platform and opportunity for breakthroughs in tumor immunotherapy. Graphical Abstract

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Hydrogel/nanoparticles-mediated cooperative combination of antiangiogenesis and immunotherapy

Cited by 7 publications

References 45 publications

NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice

NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice

Cancer Immunotherapy with “Vascular-Immune” Crosstalk as Entry Point: Associated Mechanisms, Therapeutic Drugs and Nano-Delivery Systems

Emerging biomaterials for tumor immunotherapy

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