Hydrogel‐Forming Microneedles: Current Advancements and Future Trends

Turner, Joseph G.; White, Leah R; Estrela, Pedro; Leese, Hannah S.

doi:10.1002/mabi.202000307

Cited by 211 publications

(151 citation statements)

References 100 publications

(186 reference statements)

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“…HFMs when placed into the skin, it expand and release medications while also absorbing ISF. [36] Figure 4: General drug release mechanism using a microneedle device [13] Figure 5: The overview of drug release mechanism from the different types of microneedles [36]…”

Section: Drug Delivery Mechanism Through Microneedlementioning

confidence: 99%

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Microneedles (MNs) - A versatile transdermal drug delivery system: Types, Fabrication Methodology, Release Mechanism, Evaluation Parameters, Biological Application and Clinical Case Studies

Patel¹,

Parikh²,

Patel³

et al. 2021

TJOPAM

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Because of the limitations of the oral drug delivery system, as well as the discomfort associated with the usage of needles in the case of injections, drug delivery research has shifted significantly toward the transdermal route of administration. Topical creams, gels, and transdermal patches are the most often utilised means of transdermal administration of drugs. Since the stratum corneum layer of the skin acts as a barrier to a drug molecule, the effect of the majority of therapeutic agents is limited. As a result, only a small number of molecules are able to reach the site of action. A new type of delivery method, known as microneedles, is being developed to improve the distribution of drugs through this route while also overcoming the various issues associated with existing formulations. Non-invasive and painless feature of microneedles have making them ideal for self-administration. This review describes various type of microneedles and their design, fabrication methodology, various materials used in fabrication of microneedles, drug release mechanism from the microneedles, evaluation parameters, it’s biological application, update about recent clinical studies and in last, challenges and future perspective of microneedles as drug delivery system.

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Section: Drug Delivery Mechanism Through Microneedlementioning

confidence: 99%

“…This technique has primarily been used with silicon and metal MNs. [36,37] The reactive ion etching process was utilised to create silicon hollow microneedles (MNs) that will be used to treat hemodynamic dysfunctions transdermally in patients. [38] 4.3 Laser Mediated Technology…”

Section: Dry Etchingmentioning

confidence: 99%

Microneedles (MNs) - A versatile transdermal drug delivery system: Types, Fabrication Methodology, Release Mechanism, Evaluation Parameters, Biological Application and Clinical Case Studies

Patel¹,

Parikh²,

Patel³

et al. 2021

TJOPAM

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show abstract

“… 10 , 21 The newest forms of MNs are constructed from hydrogel, which uptakes water and swell when inserted into the skin; drugs can either be incorporated into their polymeric structure or be loaded and attached on top of the needles themselves. 34 , 35 Advantages of this technique include its higher drug loading capacity, superior biocompatibility, and ability to be fabricated into various shapes. 31 , 34 However, they have a limited rate of drug delivery because the drug is released in an initial burst then a steady state.…”

Section: Introductionmentioning

confidence: 99%

“… 34 , 35 Advantages of this technique include its higher drug loading capacity, superior biocompatibility, and ability to be fabricated into various shapes. 31 , 34 However, they have a limited rate of drug delivery because the drug is released in an initial burst then a steady state. 34 …”

Section: Introductionmentioning

confidence: 99%

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Transdermal approaches to vaccinations in the COVID-19 pandemic era

Lee

Pan

Nambudiri

2021

Therapeutic Advances in Vaccines and Immunotherapy

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The COVID-19 pandemic has necessitated rapid vaccine development for the control of the disease. Most vaccinations, including those currently approved for COVID-19 are administered intramuscularly and subcutaneously using hypodermic needles. However, there are several disadvantages including pain and fear of needlesticks, the need for two doses, the need for trained health care professionals for vaccine administration, and barriers to global distribution given the need for cold supply chain. Recently, transdermal techniques have been under investigation for vaccines including COVID-19. Microneedle array technology utilizes multiple microscopic projections from a plate which delivers a vaccine in the form of a patch placed on the skin, allowing for painless antigen delivery with improved immune response. In this review, we discuss challenges of existing vaccines and review the literature on the science behind transdermal vaccines including microneedles, current evidence of application in infectious diseases including COVID-19, and considerations for implementation and global access.

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Advanced Materials for Surgical Tools and Biomedical Implants

Datta,

Barua

2023

Advanced Materials and Manufacturing Techniques for Biomedical Applications

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Hydrogel‐Forming Microneedles: Current Advancements and Future Trends

Cited by 211 publications

References 100 publications

Microneedles (MNs) - A versatile transdermal drug delivery system: Types, Fabrication Methodology, Release Mechanism, Evaluation Parameters, Biological Application and Clinical Case Studies

Microneedles (MNs) - A versatile transdermal drug delivery system: Types, Fabrication Methodology, Release Mechanism, Evaluation Parameters, Biological Application and Clinical Case Studies

Transdermal approaches to vaccinations in the COVID-19 pandemic era

Advanced Materials for Surgical Tools and Biomedical Implants

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