Hydrogel design strategies for drug delivery

Dreiss, Cécile A.

doi:10.1016/j.cocis.2020.02.001

Cited by 208 publications

(127 citation statements)

References 121 publications

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“…Another method to delivery various drug to different parts of corneal is using ocular gel. With this strategy, achievement of an optimal drug concentration at the target area is accessible [ 24 ]. Medical gels are an example of such systems that have attracted substantial attention [ 25 ].…”

Section: Methods For Cornea Drug Deliverymentioning

confidence: 99%

Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

et al. 2020

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During recent decades, researchers all around the world have focused on the characteristic pros and cons of the different drug delivery systems for cornea tissue change for sense organs. The delivery of various drugs for cornea tissue is one of the most attractive and challenging activities for researchers in biomaterials, pharmacology, and ophthalmology. This method is so important for cornea wound healing because of the controllable release rate and enhancement in drug bioavailability. It should be noted that the delivery of various kinds of drugs into the different parts of the eye, especially the cornea, is so difficult because of the unique anatomy and various barriers in the eye. Nanoparticles are investigated to improve drug delivery systems for corneal disease. Biodegradable nanocarriers for repeated corneal drug delivery is one of the most attractive and challenging methods for corneal drug delivery because they have shown acceptable ability for this purpose. On the other hand, by using these kinds of nanoparticles, a drug could reside in various part of the cornea for longer. In this review, we summarized all approaches for corneal drug delivery with emphasis on the biodegradable nanoparticles, such as liposomes, dendrimers, polymeric nanoparticles, niosomes, microemulsions, nanosuspensions, and hydrogels. Moreover, we discuss the anatomy of the cornea at first and gene therapy at the end.

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Section: Methods For Cornea Drug Deliverymentioning

confidence: 99%

Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

et al. 2020

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“…Advances in drug delivery techniques have also led to designed biomaterials that can systemically release anti-inflammatory biomolecules to eliminate inflammation. [74][75][76] Hydrogel is an ideal carrier for controllable release of anti-inflammatory molecules to ameliorate inflammatory response through sustained biomolecular diffusion. In vivo degradation behavior, which can be tailored by several factors (e.g., mass concentration, crosslinking rate, molecular weight, swelling ratio, etc.…”

Section: Drug Reservoirsmentioning

confidence: 99%

Hydrogels for Engineering the Immune System

Shou

Tay

2021

Advanced NanoBiomed Research

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Human immune system has evolved as one of the most powerful defense systems to protect against invading pathogens and mutated cells. However, when persistent immune suppression or activation occurs, it can lead to adverse, chronic physiological effects including cancer and arthritis. Hydrogels are soft materials that can be engineered to modulate immune responses through controlled biomolecule release/adsorption, regeneration of lymphoid tissues, and enhanced antigen presentations. This is achieved by programming hydrogels to exhibit optimal properties such as porosity, biodegradability, and biocompatibility to interface seamlessly with the immune system. Herein, recent innovations and future challenges are described using programmable hydrogels to regenerate the lymphatic system, modulate inflammation, and enhance cancer immunotherapy. Key properties of hydrogels are also highlighted for engineering the immune system and techniques to characterize these properties.

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“…Stimuli-responsive so materials [1][2][3][4] that can sense external environmental cues and change their size, shape, and mechanical properties have found use in a number of applications, such as actuators, 5,6 so robotics, 7,8 tissue culture, [9][10][11] and the controlled release of cells, biomolecules and drugs. [12][13][14] Oen, the responsivity is programmed into the so material at the (macro)molecular level prior to formation of a liquid crystal elastomer or gel network for example. Some common external stimuli that have been investigated previously include changes in pH [15][16][17] or temperature, [18][19][20] reduction and oxidation, [21][22][23][24] magnetic elds, 25 or irradiation with light (e.g., UV, visible, near-IR (NIR)), [26][27][28][29][30][31][32][33][34][35][36][37] where the selection of a material's responsive components is typically based on the desired application and preference for a specic external stimulus.…”

Section: Introductionmentioning

confidence: 99%