Hydrogel-complexed small-diameter vascular graft loaded with tissue-specific vascular extracellular matrix components used for tissue engineering

Long-term observation of polycaprolactone small-diameter vascular grafts with thickened outer layer and heparinized inner layer in rabbit carotid arteries

“…Furthermore, as a cell-free blood-contacting material, anticoagulation is the prerequisite for the in situ TEVGs to keep long-term patency. Heparin (Hep) modification or eluting is one of the most effective strategies to prevent the TEVGs from thrombosis formation and vascular occlusion due to the good anticoagulant and antithrombotic characteristics of Hep [18][19][20][21][22][23][24]. Furthermore, as a linear polysaccharide composed of repeating units of uronic acid, Hep can interact strongly with several different proteins and factors in a specific manner.…”

From Super Jelly to Hydrogel: Delivering Hydrogel Chemistry into Middle School Classrooms by Undergraduates as the Bridge between Professors and Students

“…Hydrogels are cross-linked hydrophilic polymeric networks that have the ability to absorb and retain a significant volume of water but not to dissolve. − Hydrogels are especially prevalent in recent works due to their use in the production of materials with customizable properties, including biocompatibility, biodegradability, sustainability, affordability, and accessibility. The aforementioned properties are essential in the development of materials for drug delivery, vaccines, skin grafting, artificial tissues, and medicinal chemistry applications. − Thus, hydrogels have occupied an important position in the polymer chemistry. On the other hand, there are many hydrogels such as jelly, diapers, and contact lenses present in daily life, so it is easy for middle school students to get a direct impression of hydrogel materials.…”