Hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms: a meta-analysis of randomized controlled trials

Xue, Tao; Chen, Zhouqing; Lin, Weiwei; Xu, Jiayi; Shen, Xuming; Wang, Zhong

doi:10.1186/s12883-018-1171-8

Cited by 8 publications

(8 citation statements)

References 32 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with the results of a current meta-analysis, 6 our study provides evidence that HSC are more efficient in treating large and giant aneurysm with better mid-term outcomes when compared with BPC. Our overall treatment results are also matching with published data of four randomized controlled trials 7 – 10 and three registries 11 – 13 .…”

Section: Discussionsupporting

confidence: 91%

Comparison between second generation HydroSoft coils and bare platinum coils for the treatment of large intracranial aneurysms

et al. 2022

View full text Add to dashboard Cite

Background The development of HydroSoft coils (HSC) aims to reduce the high recurrence and retreatment rates observed in large brain aneurysms by improving primary brain aneurysm filling and thus occlusion efficacy. We compared clinical and angiographic effectiveness of bare platinum coils (BPC) versus second generation HSC for large intracranial aneurysms at our center. Methods We included 61 large aneurysms between 2015 and 2018, 29 embolized primarily using HSC and 32 treated with BPC. The aneurysm occlusion rates were assessed after 3 and 12 months with an MRI scan and at 6 moths with a control digital subtraction angiography (DSA) using the Raymond-Roy occlusion classification (RROC). Clinical outcomes were evaluated using the modified ranking scale (mRS). Results The observed immediate occlusion rate was slightly better in the BPC group, however, this group had a significant increase of progressive reperfusion at all imaging follow-up. Contrarily, the rate of complete occlusion increased significantly in the HSC group, starting from the 6 and 12-months follow-up. 7 aneurysms (11.4%) were re-treated (15.6% BPC and 6.9% HSC). The 6 and 12-months clinical data showed mRS score 0-1 in 96.7% of patients. Conclusions In our single-center experience, the second generation HydroSoft coils were shown to be safe and effective for endovascular treatment of large intracranial aneurysms with encouraging clinical and angiographic results, also for ruptured aneurysms. Even if the validity is limited due to our small cohort size, HSC showed a significantly lower rate of recurrence at mid-term follow-up when compared to BPC.

show abstract

Section: Discussionsupporting

confidence: 91%

Comparison between second generation HydroSoft coils and bare platinum coils for the treatment of large intracranial aneurysms

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Endovascular techniques for intracranial aneurysm (IA) repair have evolved quickly over the past decades. So far only a few of the novel techniques have been investigated in prospective trials [1,2]. Most novel devices have not been studied in large prospective studies.…”

Section: Introductionmentioning

confidence: 99%

SMART coils for intracranial aneurysm repair – a single center experience

et al. 2020

View full text Add to dashboard Cite

Background: Due to uniform stiffness of standard platinum coils, dense packing of intracranial aneurysms can be difficult to achieve, since stiffer coils can cause microcatheter prolapse or coil migration. SMART coils have a varying softness along the length of the coils to improve deliverability. We report our initial 2 year experience with the SMART coil system, including direct and follow-up results. Methods: We performed a retrospective study of all patients who underwent coil embolization of an intracranial aneurysm with SMART coils between July 2016 and August 2018 at our institution. We analyzed clinical and angiographic data before and directly after treatment as well as at 6 months follow-up. Results: A total of 49 patients harboring 49 aneurysms were treated; 23 (47%) were ruptured aneurysms. Most aneurysms (57%) were located in the anterior circulation. Median patient age was 55 (31-88), 63% were female. Mean aneurysm size was: neck 3.4 (±1.5), height 6.3 (±2.9) and width 5.2 (±2.3) mm. SMART coils were solely used in 96% of cases. Initial favorable angiographic results were achieved in 45 (92%) of 49 cases, which were stable at 6 months in 26/29 (90%). Thromboembolic complications occurred in 4 (8%) cases without clinical sequelae; microcatheter prolapse occurred in 1 case. No aneurysm rupture or device malfunction was observed. Conclusion: The treatment of ruptured and unruptured intracranial aneurysms with SMART Coils was safe and efficacious in our cohort.

show abstract

“…However, other clinical trials, including the Patients Prone to Recurrence After Endovascular Treatment (PRET) trial, have demonstrated that hydrogel-coated coils do not provide improved clinical outcomes when compared to bare coils [24]. Overall, the meta-analysis of the performance of hydrogel coils demonstrated that the second-generation hydrogel coils (HydroSoft) might improve residual aneurysm and midterm recurrence, but do not exhibit any other significant differences to the traditional GDC coiling [25].…”

Section: Hydrogel-coated Coilsmentioning

confidence: 97%

Shape Memory Polymer-Based Endovascular Devices: Design Criteria and Future Perspective

et al. 2022

View full text Add to dashboard Cite

Devices for the endovascular embolization of intracranial aneurysms (ICAs) face limitations related to suboptimal rates of lasting complete occlusion. Incomplete occlusion frequently leads to residual flow within the aneurysm sac, which subsequently causes aneurysm recurrence needing surgical re-operation. An emerging method for improving the rates of complete occlusion both immediately after implant and in the longer run can be the fabrication of patient-specific materials for ICA embolization. Shape memory polymers (SMPs) are materials with great potential for this application, owing to their versatile and tunable shape memory properties that can be tailored to a patient’s aneurysm geometry and flow condition. In this review, we first present the state-of-the-art endovascular devices and their limitations in providing long-term complete occlusion. Then, we present methods for the fabrication of SMPs, the most prominent actuation methods for their shape recovery, and the potential of SMPs as endovascular devices for ICA embolization. Although SMPs are a promising alternative for the patient-specific treatment of ICAs, there are still limitations that need to be addressed for their application as an effective coil-free endovascular therapy.

show abstract

Hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms: a meta-analysis of randomized controlled trials

Cited by 8 publications

References 32 publications

Comparison between second generation HydroSoft coils and bare platinum coils for the treatment of large intracranial aneurysms

Comparison between second generation HydroSoft coils and bare platinum coils for the treatment of large intracranial aneurysms

SMART coils for intracranial aneurysm repair – a single center experience

Shape Memory Polymer-Based Endovascular Devices: Design Criteria and Future Perspective

Contact Info

Product

Resources

About