Hydrogel-based therapeutic coatings for dental implants

Alavi, Seyed Ebrahim; Panah, Naomi; Page, Franck; Gholami, Max; Dastfal, Alireza; Sharma, Lavanya Ajay; Shahmabadi, Hasan Ebrahimi

doi:10.1016/j.eurpolymj.2022.111652

Cited by 11 publications

(4 citation statements)

References 145 publications

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“…Hydrogel scaffolds, defined by their elevated water content and hydrophilic polymer chains, possess distinct characteristics such as biocompatibility, elasticity, and the ability for chemical modification. They can imitate the ECM and serve as a growth medium for cells and tissues [82][83][84]. Due to these properties, hydrogels find widespread applications in biomedical research, including drug delivery and various regenerative medicine approaches, such as bone tissue regeneration [82,85].…”

Section: Graft Retention and Stabilitymentioning

confidence: 99%

Resorbable GBR Scaffolds in Oral and Maxillofacial Tissue Engineering: Design, Fabrication, and Applications

Alavi,

Gholami,

Shahmabadi

et al. 2023

JCM

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Guided bone regeneration (GBR) is a promising technique in bone tissue engineering that aims to replace lost or injured bone using resorbable scaffolds. The promotion of osteoblast adhesion, migration, and proliferation is greatly aided by GBR materials, and surface changes are critical in imitating the natural bone structure to improve cellular responses. Moreover, the interactions between bioresponsive scaffolds, growth factors (GFs), immune cells, and stromal progenitor cells are essential in promoting bone regeneration. This literature review comprehensively discusses various aspects of resorbable scaffolds in bone tissue engineering, encompassing scaffold design, materials, fabrication techniques, and advanced manufacturing methods, including three-dimensional printing. In addition, this review explores surface modifications to replicate native bone structures and their impact on cellular responses. Moreover, the mechanisms of bone regeneration are described, providing information on how immune cells, GFs, and bioresponsive scaffolds orchestrate tissue healing. Practical applications in clinical settings are presented to underscore the importance of these principles in promoting tissue integration, healing, and regeneration. Furthermore, this literature review delves into emerging areas of metamaterials and artificial intelligence applications in tissue engineering and regenerative medicine. These interdisciplinary approaches hold immense promise for furthering bone tissue engineering and improving therapeutic outcomes, leading to enhanced patient well-being. The potential of combining material science, advanced manufacturing, and cellular biology is showcased as a pathway to advance bone tissue engineering, addressing a variety of clinical needs and challenges. By providing this comprehensive narrative, a detailed, up-to-date account of resorbable scaffolds’ role in bone tissue engineering and their transformative potential is offered.

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Section: Graft Retention and Stabilitymentioning

confidence: 99%

Resorbable GBR Scaffolds in Oral and Maxillofacial Tissue Engineering: Design, Fabrication, and Applications

Alavi,

Gholami,

Shahmabadi

et al. 2023

JCM

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“…In different clinical situations, dental implants have become indispensable, establishing therapy with success rates of 82.9% that has been recognized in a 16-year follow-up study [2]. However, implants can be rejected due to inflammation and biological complications, such as peri-implantitis, caused by oral microflora [3,4]. Peri-implantitis is a type of peri-implant disease relating to implant sites that could result in the loss of the implant [5,6].…”

Section: Introductionmentioning

confidence: 99%

Peri-Implantitis Therapy Using Surgical Methods: A Systematic Review

et al. 2023

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This study is a systematic review evaluating published literature on the effect of surgical treatments on peri-implantitis. Various databases were selected for the literature search on the topic. The considered primary clinical parameters were changes in probing pocket depth (PPD), bleeding on probing (BoP), radiographic bone change, plaque score, signs of infection, and implant loss. Five research studies comprising 20 or more sample sizes (patients) with minimal two-year follow-up after surgical treatment were selected, based on preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. In all five studies, PPD and BoP were significantly reduced compared to those before intervention. However, there was no significant variation in the patients treated with open flap debridement, citric acid decontamination, and subepithelial connective tissue graft. The highest reduction of BoP was recorded in the study utilizing regenerative surgical therapy, deproteinized bovine bone mineral containing 10% collagen, the derivative of enamel matrix, and doxycycline. According to the two–five-year follow-up of this systemic review, surgical treatment, including bone substitute material, showed clinical improvement in the reviewed studies, compared to that before intervention; however, there was no statistical significance in the clinical outcome of the selected studies.

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“…The combination of various natural and synthetic hydrogels holds promise for achieving the regeneration and repair of craniofacial and oral tissues. More importantly, hydrogels are stimulus-responsive, meaning they can change their structure, physical properties, chemical composition, and elasticity modulus in response to external stimuli such as changes in temperature, pH, ionic strength, light, magnetic, electrical, or mechanical signals [19]. Natural hydrogels such as Molecules 2023, 28, 3946 3 of 25 alginate, hyaluronic acid (HA), gelatin, collagen, and chitosan (CS) are often used, while synthetic hydrogels such as polylactic acid (PLA), polyethylene glycol (PEG), and gelatin methacryloyl (GelMA) are frequently used in biomedical applications [20].…”

Section: Introductionmentioning

confidence: 99%

Hydrogels for Oral Tissue Engineering: Challenges and Opportunities

Chen,

Deng,

Lai

et al. 2023

Molecules

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Oral health is crucial to daily life, yet many people worldwide suffer from oral diseases. With the development of oral tissue engineering, there is a growing demand for dental biomaterials. Addressing oral diseases often requires a two-fold approach: fighting bacterial infections and promoting tissue growth. Hydrogels are promising tissue engineering biomaterials that show great potential for oral tissue regeneration and drug delivery. In this review, we present a classification of hydrogels commonly used in dental research, including natural and synthetic hydrogels. Furthermore, recent applications of these hydrogels in endodontic restorations, periodontal tissues, mandibular and oral soft tissue restorations, and related clinical studies are also discussed, including various antimicrobial and tissue growth promotion strategies used in the dental applications of hydrogels. While hydrogels have been increasingly studied in oral tissue engineering, there are still some challenges that need to be addressed for satisfactory clinical outcomes. This paper summarizes the current issues in the abovementioned application areas and discusses possible future developments.

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Hydrogel-based therapeutic coatings for dental implants

Cited by 11 publications

References 145 publications

Resorbable GBR Scaffolds in Oral and Maxillofacial Tissue Engineering: Design, Fabrication, and Applications

Resorbable GBR Scaffolds in Oral and Maxillofacial Tissue Engineering: Design, Fabrication, and Applications

Peri-Implantitis Therapy Using Surgical Methods: A Systematic Review

Hydrogels for Oral Tissue Engineering: Challenges and Opportunities

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