Hydrogel‐Based Sensing for Living Biosystems

Abstract

Long‐term in vivo monitoring of chemicals with implantable sensors has garnered significant interest in recent decades due to their profound impact on reflecting health conditions and aiding in disease diagnosis. Hydrogel‐based sensors have emerged as a promising choice for such applications, owing to their swellable, nano‐/microporous, and aqueous 3D structures, as well as their ability to maintain adjustable mechanical properties in wearable and implantable devices. This article presents a comprehensive review of the advancements in hydrogel‐based sensors for living biosystems, encompassing hydrogel synthesis, functionalization, and sensing properties, along with their in vivo applications. Additionally, the article explores key challenges, implementable strategies, and future design possibilities that hold potential for researchers seeking to develop innovative, multifunctional smart sensors. image