Hydrogel-based dressings designed to facilitate wound healing

Zhang, Wei; Liu, Lulu; Cheng, Hui; Zhu, Jing; Li, Xinyi; Ye, Sheng; Li, Xiaojing

doi:10.1039/d3ma00682d

Cited by 3 publications

(1 citation statement)

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“…7 Hydrogels, characterized by three-dimensional network structures composed of chemically or physically crosslinked polymers, are increasingly regarded by scholars as the optimal choice for wound management. 8–10 Hydrogels can maintain a profoundly moist environment, simulate the extracellular matrix (ECM), and provide a protective barrier against bacterial and microbial intrusion. 11–13 Hydrogels have been widely studied and applied in biomedical fields such as tissue engineering, wound dressing, and drug delivery.…”

Section: Introductionmentioning

confidence: 99%

l-Carnosine loaded on carboxymethyl cellulose hydrogels for promoting wound healing

Zhang,

Li,

Chen

et al. 2024

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

l-Carnosine loaded on carboxymethyl cellulose hydrogels for promoting wound healing

Zhang,

Li,

Chen

et al. 2024

RSC Adv.

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Template-free method synthesized NaxCa2.38-xAl2Si57.2O118.59 zeolite particles for enhanced stability

Xia,

Ma,

Qin

et al. 2024

Preprint

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Zeolites have been shown to accelerate hemostasis, improve trauma healing, and provide the resulting multifunctional hemostatic materials, due to their distinctive microporous structure and interfacial properties. However, natural zeolites general contain impurities and it is difficult to produce hemostatic powder of appropriate size using direct crushing methods. Herein, we develop a template free one-step hydrothermal process to synthesized NaxCa2.38−xAl2Si57.2O118.59 zeolite particles with controllable size. The size of NaxCa2.38−xAl2Si57.2O118.59 zeolite particles can be controlled from 1 to 10 µm. The ordered pores in the synthesized NaxCa2.38−xAl2Si57.2O118.59 zeolites exhibit a typical two-dimensional hexagonal structure. The synthesized zeolites exhibit excellent stability in both natural environments and serum. The Na2.38Al2Si57.2O118.59 zeolite particles maintain high stability of morphology and structure after water flow treatment. Those stability results ensure the preservation and use possibility of zeolite hemostatic powder in special environments, such as battlefield, underwater, and extreme weather.

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Oxidized Bacterial Cellulose Membranes Immobilized with Papain for Dressing Applications: Physicochemical and In Vitro Biological Properties

Vasconcelos,

Chevallier,

Mantovani

et al. 2024

Pharmaceutics

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This research consolidates our group’s advances in developing a therapeutic dressing with innovative enzymatic debridement, focusing on the physicochemical and in vitro biological properties of papain immobilized in wet oxidized bacterial cellulose (OxBC–Papain) dressing. OxBC membranes were produced with Komagataeibacter hansenii oxidized with NaIO4, and papain was immobilized on them. They were characterized in terms of enzyme stability (over 100 days), absorption capacity, water vapor transmission (WVT), hemocompatibility, cytotoxicity, and cell adhesion. The OxBC–Papain membrane showed 68.5% proteolytic activity after 100 days, demonstrating the benefit of using the OxBC wet membrane for papain stability. It had a WVT rate of 678 g/m2·24 h and cell viability of 99% and 86% for L929 and HaCat cells, respectively. The membranes exhibited non-hemolytic behavior and maintained 26% clotting capacity after 1 h. The wet OxBC–Papain membrane shows significant potential as a natural biomolecule-based therapeutic dressing for wound care, offering efficient debridement, moisture maintenance, exudate absorption, gas exchange, and hemostasis without cytotoxic effects or cell adhesion to the dressing. Further research, especially using in vivo models, is needed to assess its efficacy in inducing epithelialization. This study advances stomatherapy knowledge, providing a cost-effective solution for enzymatic debridement in healthcare.

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Hydrogel-based dressings designed to facilitate wound healing

Abstract: The escalating prevalence of wounds, particularly chronic wounds, poses significant challenges in terms of treatment management and has led to an increase in healthcare expenditure. Hydrogel-based dressings play a crucial...

Cited by 3 publications

References 325 publications

l-Carnosine loaded on carboxymethyl cellulose hydrogels for promoting wound healing

l-Carnosine loaded on carboxymethyl cellulose hydrogels for promoting wound healing

Template-free method synthesized NaxCa2.38-xAl2Si57.2O118.59 zeolite particles for enhanced stability

Oxidized Bacterial Cellulose Membranes Immobilized with Papain for Dressing Applications: Physicochemical and In Vitro Biological Properties

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