Hydrogel‐Based Delivery of antimiR‐195 Improves Cardiac Efficacy after Ischemic Injury
Joep E. C. Eding,
Marta Vigil‐Garcia,
Marit Vink
et al.
Abstract:MicroRNAs (miRs) are potent regulators of biology and disease. The miR‐15 family is shown to regulate cardiomyocyte proliferation and antimiR‐based inhibition induces a cardioprotective effect after myocardial infarction in mice. However, systemic delivery of antimiRs leads to accumulation in kidneys and liver, with relatively poor cardiac exposure. Injectable hydrogels are proposed to serve as sustained‐release drug delivery depots and can potentially be used to improve cardiac efficacy of antimiR therapeutic… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.