Hydrodynamik und Lösungsgeschwindigkeit - Untersuchungen zum Einfluss der Hydrodynamik auf die Lösungsgeschwindigkeit schwer wasserlöslicher Arzneistoffe (rev. Fassung 2022) : Hydrodynamics and Dissolution - Influence of Hydrodynamics on Dissolution Rate of Poorly Soluble Drugs (rev. version 2022)
Steffen M. Diebold
Abstract:The objectives of the present study were to (1) examine both the hydrodynamics of compendial in vitro dissolution test apparatus as well as the respective in vivo gastrointestinal hydrodynamics in dogs, (2) describe the influence of hydrodynamics on the dissolution rates of poorly soluble drugs and (3) to develop a hydrodynamic based model to a priori predict dissolution rates of poorly soluble compounds. Hydrodynamics of compendial dissolution test apparatus (paddle and basket) were directly characterized by … Show more
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