Hydrodynamics and mass transfer in bubble column, conventional airlift, stirred airlift and stirred tank bioreactors, using viscous fluid: A comparative study

Jesus, Sérgio S. de; Neto, João Moreira; Filho, Rubens Maciel

doi:10.1016/j.bej.2016.11.019

Cited by 79 publications

(36 citation statements)

References 32 publications

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“…Stirred tanks are predominantly used, due to their operability and ease of manufacturing. However, the impeller-mediated mixing can induce very high shear stresses on the cells [ 65 ], which is why many CM startups turn to rocking platform BRs, that causes lower shear stress, due to gentle wave-like fluid motion in the cellbag [ 66 ]. Other promising candidates include hollow fiber [ 8 ] and air-lift [ 67 ] bioreactors, but also modifications of the conventional stirred tank and rocking platform BRs, such as by other methods for inducing the wave-motion, e.g., by using a horizontal displacement in combination with a rocking motion, which can increase the mass transfer capacity [ 68 ].…”

Section: Bioreactors and Scaffoldingmentioning

confidence: 99%

Cultivating Multidisciplinarity: Manufacturing and Sensing Challenges in Cultured Meat Production

Djisalov

Knežić

Podunavac

et al. 2021

Biology

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Meat cultivation via cellular agriculture holds great promise as a method for future food production. In theory, it is an ideal way of meat production, humane to the animals and sustainable for the environment, while keeping the same taste and nutritional values as traditional meat and having additional benefits such as controlled fat content and absence of antibiotics and hormones used in the traditional meat industry. However, in practice, there is still a number of challenges, such as those associated with the upscale of cultured meat (CM). CM food safety monitoring is a necessary factor when envisioning both the regulatory compliance and consumer acceptance. To achieve this, a multidisciplinary approach is necessary. This includes extensive development of the sensitive and specific analytical devices i.e., sensors to enable reliable food safety monitoring throughout the whole future food supply chain. In addition, advanced monitoring options can help in the further optimization of the meat cultivation which may reduce the currently still high costs of production. This review presents an overview of the sensor monitoring options for the most relevant parameters of importance for meat cultivation. Examples of the various types of sensors that can potentially be used in CM production are provided and the options for their integration into bioreactors, as well as suggestions on further improvements and more advanced integration approaches. In favor of the multidisciplinary approach, we also include an overview of the bioreactor types, scaffolding options as well as imaging techniques relevant for CM research. Furthermore, we briefly present the current status of the CM research and related regulation, societal aspects and challenges to its upscaling and commercialization.

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Section: Bioreactors and Scaffoldingmentioning

confidence: 99%

Cultivating Multidisciplinarity: Manufacturing and Sensing Challenges in Cultured Meat Production

Djisalov

Knežić

Podunavac

et al. 2021

Biology

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“…El uso de biorreactores con agitación neumática ha resultado más eficiente ya que la agitación mecánica provoca un mayor esfuerzo de corte, y por lo tanto, la ruptura de los filamentos, provocando así la disminución de la actividad enzimática (Ahamed y Vermette, 2010). Es por ello que se han enfocado las investigaciones en el campo de la biotecnología de hongos utilizando biorreactores air-lift que favorecen la transferencia de masa, disminuyen el esfuerzo de corte, y minimizan el consumo de energía (Fontana et al, 2009;Mahmood et al, 2015;de Jesús et al, 2017), además, favorecen la formación de pellets que permiten periodos prolongados de producción de celulasas con biomasa fúngica retenida (Callow et al, 2016). En la Fig.…”

Section: Diseño De Bioprocesos Para La Producción De Biomasa Y Metabounclassified

Trichoderma: IMPORTANCIA AGRÍCOLA, BIOTECNOLÓGICA, Y SISTEMAS DE FERMENTACIÓN PARA PRODUCIR BIOMASA Y ENZIMAS DE INTERÉS INDUSTRIAL

Hernández-Melchor

Ferrera‐Cerrato

Alarcón

2019

Chil. j. agric. anim. sci.

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Trichoderma es un hongo cosmopolita cuya importancia radica en su capacidad de adaptación y producción de metabolitos, como enzimas, compuestos promotores de crecimiento vegetal, y compuestos volátiles, entre otros, de interés biotecnológico y ambiental. Este género es utilizado como agente de biocontrol contra hongos fitopatógenos debido a sus múltiples mecanismos de acción, destacando la antibiosis, el micoparasitismo, la competencia por espacio y nutrientes, y la producción de metabolitos secundarios. Varias especies de Trichoderma se han utilizado en sistemas acoplados de fermentación en sustratos sólidos o cultivos sumergidos, para degradar residuos lignocelulósicos y para generar energías alternativas como etanol. Los biorreactores como sistemas de fermentación optimizan las condiciones del cultivo para favorecer la generación de biomasa y metabolitos. Por lo anterior, el presente trabajo recopila información de los avances recientes del uso de Trichoderma en sistemas de producción y generación de subproductos de importancia para la agricultura y la biotecnología.

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“…The system heat load includes the heat loss of the slurry tank and MFD, and the heat load of slurry, which requires heating to reach the target digestion temperature. By neglecting the bio-heat and the heat removed by the biogas, the total heat demand can be expressed as [33]: (9) where QS is the heat required by the operation of the dynamic anaerobic digestion system, kW; QDemand is the heat duty from the dynamic anaerobic digestion system, kW; Q1 is the heat required for heating the biomass digestive fluid, kW; and Q2 is the heat loss from the MFD and slurry tank, kW.…”

Section: System Heat Load Calculationmentioning

confidence: 99%

“…De Jesus et al evaluated the hydrodynamic mass transfer of four bioreactors using a viscous Newtonian and non-Newtonian fluid. It was concluded that mechanical mixing has higher mass transfer coefficients and provides a better homogeneity of the digester contents [9]. Trad et al compared the three mixing methods and found that the mixing energy level (MEL) for mechanical mixing was the highest.…”

Section: Introductionmentioning

confidence: 99%

Biogas Production and Heat Transfer Performance of a Multiphase Flow Digester

Guo

Zhou

et al. 2019

Energies

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Traditional static anaerobic digestion technology presents the disadvantages of a low gas production rate and long digestion cycle, which is not conducive to the treatment of livestock manure. A 12 m3 multiphase flow anaerobic digester (MFD) was developed in this study to improve the biogas production rate and maintain constant temperature digestion during winters. Full-scale field experiments were conducted on the biogas production rate at different temperatures, the dynamic digestion effects, and the dynamic heating digestion effects of the system at Sichuan, China. A comparison of the dynamic and static digestion results of 50 days indicated that the biogas production for the dynamic digestion (DD) group was 115.22 m3 or 127.1% higher than that of the static digestion (SD) group with the same digestion temperature. The results of the heat transfer performance experiment revealed that the heat transfer rate of the system increased significantly, and the temperature of the biogas slurry increased rapidly. The optimization analysis of the system was based on the experimental results of the relationship between the slurry temperature and biogas production rate, and the economical digestion temperature of the system was proposed and calculated. Different insulation materials or insulation thicknesses have an influence on the economical digestion temperature. Additionally, the economical digestion temperature of the system in which the polystyrene insulation layer with a thickness of 90 mm was used, was found to be 27.2 °C. When digestion temperature was 22.3 °C, the energy efficiency ratio (EER) of dynamic anaerobic digestion system is 1. The advantages of MFD are low biogas production unit cost and high heat and mass transfer rate. However, the disadvantage of high operation energy consumption needs further improvement. And additional energy was required when system digestion temperature below 22.3 °C. The proposed MFD and dynamic anaerobic digestion system can play a significant role in using biomass resources and promoting the development of biogas projects.

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Hydrodynamics and mass transfer in bubble column, conventional airlift, stirred airlift and stirred tank bioreactors, using viscous fluid: A comparative study

Cited by 79 publications

References 32 publications

Cultivating Multidisciplinarity: Manufacturing and Sensing Challenges in Cultured Meat Production

Cultivating Multidisciplinarity: Manufacturing and Sensing Challenges in Cultured Meat Production

Trichoderma: IMPORTANCIA AGRÍCOLA, BIOTECNOLÓGICA, Y SISTEMAS DE FERMENTACIÓN PARA PRODUCIR BIOMASA Y ENZIMAS DE INTERÉS INDUSTRIAL

Biogas Production and Heat Transfer Performance of a Multiphase Flow Digester

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