Hydrodynamic Trapping of Particles in an Expansion-Contraction Microfluidic Device

Wang, Ruijin

doi:10.1155/2013/496243

Cited by 8 publications

(2 citation statements)

References 25 publications

(25 reference statements)

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“…On the other hand, a hydrodynamic isolation approach is based on hydrodynamic inertial effect in a continuous and precisely controlled flow due to the interaction between cell and obstacles in the microfluidic channels. Deterministic lateral displacement (DLD) [ 34 ], Microvortex [ 35 ], Dean flow fractionalization [ 36 ] and pinch flow [ 37 ] are the approaches used for the inertial separation of CTCs ( Table 1 ).…”

Section: Microfluidic Devices In Cancer Researchmentioning

confidence: 99%

Applications of Microfluidics and Organ-on-a-Chip in Cancer Research

et al. 2022

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Taking the life of nearly 10 million people annually, cancer has become one of the major causes of mortality worldwide and a hot topic for researchers to find innovative approaches to demystify the disease and drug development. Having its root lying in microelectronics, microfluidics seems to hold great potential to explore our limited knowledge in the field of oncology. It offers numerous advantages such as a low sample volume, minimal cost, parallelization, and portability and has been advanced in the field of molecular biology and chemical synthesis. The platform has been proved to be valuable in cancer research, especially for diagnostics and prognosis purposes and has been successfully employed in recent years. Organ-on-a-chip, a biomimetic microfluidic platform, simulating the complexity of a human organ, has emerged as a breakthrough in cancer research as it provides a dynamic platform to simulate tumor growth and progression in a chip. This paper aims at giving an overview of microfluidics and organ-on-a-chip technology incorporating their historical development, physics of fluid flow and application in oncology. The current applications of microfluidics and organ-on-a-chip in the field of cancer research have been copiously discussed integrating the major application areas such as the isolation of CTCs, studying the cancer cell phenotype as well as metastasis, replicating TME in organ-on-a-chip and drug development. This technology’s significance and limitations are also addressed, giving readers a comprehensive picture of the ability of the microfluidic platform to advance the field of oncology.

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Section: Microfluidic Devices In Cancer Researchmentioning

confidence: 99%

Applications of Microfluidics and Organ-on-a-Chip in Cancer Research

et al. 2022

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“…The geometry of the microchannel will define the fluid flow streams and the consequent forces. Four types of microchannels have been used in inertial particle manipulation: straight [25][26], expansion-contraction [27], [28], spiral [29][30], and serpentine microchannels [31]. Some researches prefer to combine these types and use them in different stages of manipulation [32].…”

Section: Acoustophoresismentioning

confidence: 99%