Hydrodynamic repulsion of spheroidal microparticles from micro-rough surfaces

Belyaev, Aleksey V.

doi:10.1371/journal.pone.0183093

Cited by 12 publications

(11 citation statements)

References 34 publications

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“…The coupling between fluid flow and cell membrane was introduced by a viscous drag force F j = −ξ∆u j exerted on the cell membrane nodes. The hydrodynamic part of the model has been successfully used in prior works [55,58]. Before each simulation the ligand polymer (tether) was attached to the bottom wall of the simulation box by one end and stretched along the x-axis.…”

Section: A 3d Computer Model Has Been Developed On the Basis Of The O...mentioning

confidence: 99%

Long ligands reinforce biological adhesion under shear flow

Belyaev

2018

Phys. Rev. E

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In this work, computer modeling has been used to show that longer ligands allow biological cells (e.g., blood platelets) to withstand stronger flows after their adhesion to solid walls. A mechanistic model of polymer-mediated ligand-receptor adhesion between a microparticle (cell) and a flat wall has been developed. The theoretical threshold between adherent and non-adherent regimes has been derived analytically and confirmed by simulations. These results lead to a deeper understanding of numerous biophysical processes, e.g., arterial thrombosis, and to the design of new biomimetic colloid-polymer systems.

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Section: A 3d Computer Model Has Been Developed On the Basis Of The O...mentioning

confidence: 99%

Long ligands reinforce biological adhesion under shear flow

Belyaev

2018

Phys. Rev. E

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“…The PyOIF has been further used by external research groups for evaluation of VAD rotatory blood pumps [ 54 ], for analysis of micro-roughness and its consequences for platelets activation and platelet catching [ 55 , 56 ], for simulation of magnetic active polymers for versatile microfluidic devices [ 57 ]. Recently, the PyOIF module has been used to investigate the equilibrium structure and quasi-static deformational response of a magnetic polymersome, a hollow object whose magnetoactive part is its shell [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

PyOIF: Computational tool for modelling of multi-cell flows in complex geometries

et al. 2020

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A user ready, well documented software package PyOIF contains an implementation of a robust validated computational model for cell flow modelling. The software is capable of simulating processes involving biological cells immersed in a fluid. The examples of such processes are flows in microfluidic channels with numerous applications such as cell sorting, rare cell isolation or flow fractionation. Besides the typical usage of such computational model in the design process of microfluidic devices, PyOIF has been used in the computer-aided discovery involving mechanical properties of cell membranes. With this software, single cell, many cell, as well as dense cell suspensions can be simulated. Many cell simulations include cell-cell interactions and analyse their effect on the cells. PyOIF can be used to test the influence of mechanical properties of the membrane in flows and in membrane-membrane interactions. Dense suspensions may be used to study the effect of cell volume fraction on macroscopic phenomena such as cell-free layer, apparent suspension viscosity or cell degradation. The PyOIF module is based on the official ESPResSo distribution with few modifications and is available under the terms of the GNU General Public Licence. PyOIF is based on Python objects representing the cells and on the C++ computational core for fluid and interaction dynamics. The source code is freely available at GitHub repository, runs natively under Linux and MacOS and can be used in Windows Subsystem for Linux. The communication among PyOIF users and developers is maintained using active mailing lists. This work provides a basic background to the underlying computational models and to the implementation of interactions within this framework. We provide the prospective PyOIF users with a practical example of simulation script with reference to our publicly available User Guide.

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“…The opposite force was transferred back to the fluid. The parameter of friction ξ = 0.5 was adjusted from the calibration procedure [3,10,14]. The same approach was used for the coupling between the polymers and the fluid.…”

Section: Methodsmentioning

confidence: 99%

Catching platelets from the bloodflow: the role of the conformation of von Willebrand factor

Belyaev

2018

Math. Model. Nat. Phenom.

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The mechanics of platelet initial adhesion due to interactions between GPIb receptor with von Willebrand factor (vWf) multimers is essential for thrombus growth and the regulation of this process. Multimeric structure of vWf is known to make adhesion sensitive to the hydrodynamic conditions, providing intensive platelet aggregation in bulk fluid for high shear rates. But it is still unclear how it affects the dynamics of platelet motion near vessel walls and efficiency of their adhesion to surfaces. Our goal is to resolve the principal issues in the mechanics of platelet initial attachment via GPIb-vWf bonds in near-wall flow conditions: when the platelet tends to roll or slide and how this dynamics depends on the size, conformation and adhesive properties of the vWf multimers. We employ a 3D computer model based on a combination of the Lattice Boltzmann method with mesoscopic particle dynamics for explicit simulation of vWf-mediated blood platelet adhesion in shear flow. Our results reveal the link between the mechanics of platelet initial adhesion and the physico-chemical properties of vWf multimers. This has implications in further theoretical investigation of thrombus growth dynamics, as well as the interpretation of in vitro experimental data.

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Hydrodynamic repulsion of spheroidal microparticles from micro-rough surfaces

Cited by 12 publications

References 34 publications

Long ligands reinforce biological adhesion under shear flow

Long ligands reinforce biological adhesion under shear flow

PyOIF: Computational tool for modelling of multi-cell flows in complex geometries

Catching platelets from the bloodflow: the role of the conformation of von Willebrand factor

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