Hydrodynamic extensional stress during the bubble bursting process for bioreactor system design

Tran, Thanh Tinh; Lee, Eun Gyo; Lee, In Su; Woo, Nam-Sub; Han, Sang Mok; Kim, Young Ju; Hwang, Wook Ryol

doi:10.1007/s13367-016-0032-5

Cited by 10 publications

(13 citation statements)

References 44 publications

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“…The expansion of the micro-bubble volume in the last panel indicates the large localized pressure driving up the singular jet (Tran et al. 2016; Thoroddsen et al. 2018; Gordillo & Rodríguez-Rodríguez 2019).…”

Section: Discussionmentioning

confidence: 99%

Multitude of dimple shapes can produce singular jets during the collapse of immiscible drop-impact craters

2020

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Section: Discussionmentioning

confidence: 99%

Multitude of dimple shapes can produce singular jets during the collapse of immiscible drop-impact craters

2020

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“…Sparging and the bursting of bubbles ( Figure 9 ) has been considered as the main cause of cell damage in a bioreactor [ 96 , 97 , 98 , 99 ]. Addition of surfactant such as Pluronic F68 can mitigate the damage from the opposing jets that form as a bubble bursts at the gas–liquid interface.…”

Section: Cell Injury By Hydrodynamic Stressmentioning

confidence: 99%

“…Based on energy dissipation, smaller bubbles are more harmful to cells [ 22 , 101 , 102 ] with damage to insect cells being found to be inversely related to bubble size [ 99 ]. Tran conducted numerical simulations to investigate the effect of bubble diameter (0.5–6 mm) and surface tension (0.03–0.072 N/m) on the maximum extensional stress [ 96 ]. This resulted in the following equation for the maximum stress:

where bubble diameter d b is in mm and surface tension σ is in N/m and the stress is in Pa.…”

Section: Cell Injury By Hydrodynamic Stressmentioning

confidence: 99%

Elongational Stresses and Cells

Foster

Papavassiliou

O’Rear

2021

Cells

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Fluid forces and their effects on cells have been researched for quite some time, especially in the realm of biology and medicine. Shear forces have been the primary emphasis, often attributed as being the main source of cell deformation/damage in devices like prosthetic heart valves and artificial organs. Less well understood and studied are extensional stresses which are often found in such devices, in bioreactors, and in normal blood circulation. Several microfluidic channels utilizing hyperbolic, abrupt, or tapered constrictions and cross-flow geometries, have been used to isolate the effects of extensional flow. Under such flow cell deformations, erythrocytes, leukocytes, and a variety of other cell types have been examined. Results suggest that extensional stresses cause larger deformation than shear stresses of the same magnitude. This has further implications in assessing cell injury from mechanical forces in artificial organs and bioreactors. The cells’ greater sensitivity to extensional stress has found utility in mechanophenotyping devices, which have been successfully used to identify pathologies that affect cell deformability. Further application outside of biology includes disrupting cells for increased food product stability and harvesting macromolecules for biofuel. The effects of extensional stresses on cells remains an area meriting further study.

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“…Bursting of gas bubbles at a liquid–air interface is a common phenomenon in many natural and industrial processes, − the most common examples being the formation of sea spray aerosol − and the effervescence of sparkling beverages. − The mechanism of bursting bubble aerosol formation has been extensively studied for several decades, both from the physical − and chemical − points of view. One of the most interesting aspects of the bubble bursting process is the substantial enrichment of surface-active organic matter in the bursting bubble aerosol relative to the bulk solution. − Earlier studies revealed that soluble organic carbon in sea spray aerosols is enriched by, on average, several hundred times relative to the bulk sea water, and this phenomenon has an important impact on the global Earth’s climate. ,, It has been also demonstrated that the enriched content of surface-active compounds in fizzy aerosols is largely responsible for the characteristic organoleptic properties of sparkling beverages. , Recently, bubble bursting has also been demonstrated as a potentially useful approach for the analytical preconcentration of organic solutes. , …”

Section: Introductionmentioning

confidence: 99%

Enrichment of Surface-Active Compounds in Bursting Bubble Aerosols

et al. 2018

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The pronounced enrichment of surface-active compounds in the aerosols produced by bubble bursting plays a central role in the chemical transfer from the ocean into the atmosphere and has an important impact on the global Earth’s climate. However, the mechanism of chemical enrichment in bursting bubble aerosols remains poorly understood and controversial due to the high complexity and diversity of experimental behaviors. Contrary to the common belief, here we show that the major share of surfactants in the jet droplets produced by individually bursting bubbles at a calm solution surface is released directly from the bubble surface rather than from the solution surface or subsurface microlayer. We reveal that surfactants are accumulated at the surface of a rising bubble in solution following three successive stages with strongly distinct adsorption profiles: linear kinetic, mixed kinetic, and equilibrium. The magnitude of surfactant enrichment in the aerosol is directly determined by which adsorption mode is in control by the moment of the bubble bursting at solution surface. Our mechanistic description explains the diversity of experimental observations regarding the surfactant enrichment in aerosol droplets and lays the ground for understanding the more complex behaviors associated with collective effects at the solution surface (e.g., breaking waves).

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Hydrodynamic extensional stress during the bubble bursting process for bioreactor system design

Cited by 10 publications

References 44 publications

Multitude of dimple shapes can produce singular jets during the collapse of immiscible drop-impact craters

Multitude of dimple shapes can produce singular jets during the collapse of immiscible drop-impact craters

Elongational Stresses and Cells

Enrichment of Surface-Active Compounds in Bursting Bubble Aerosols

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